Pharm: DM med classes, MOAs

Question 1

class: Acarbose/Precose

Answer 1

Alpha Glucosidase Inhibitors

Question 2

class: miglitol/Glycet

Answer 2

Alpha Glucosidase Inhibitors

Question 3

class: Repaglinide

Answer 3

Meglitinides

Question 4

class: nateglinide

Answer 4

Meglitinides

Question 5

class: Glyburide

Answer 5

Sulfonylureas

Question 6

class: glipizide

Answer 6

Sulfonylureas

Question 7

class: glimepiride

Answer 7

Sulfonylureas

Question 8

class: metformin

Answer 8

Biguanide

Question 9

class: Pioglitazone

Answer 9

Thiazolidinediones (Glitazones)

Question 10

class: rosiglitazone

Answer 10

Thiazolidinediones (Glitazones)

Question 11

class: Sitagliptin

Answer 11

Dipeptidyl peptidase-4 Inhibitors (DPP-4)

Question 12

class: saxagliptin

Answer 12

Dipeptidyl peptidase-4 Inhibitors (DPP-4)

Question 13

class: linagliptin

Answer 13

Dipeptidyl peptidase-4 Inhibitors (DPP-4)

Question 14

class: Canaglifozin

Answer 14

Selective Sodium-Dependent Glucose Cotransporter-2 Inhibitor (SGLT2 Inhibitors)

Question 15

class: dapaglifozine

Answer 15

Selective Sodium-Dependent Glucose Cotransporter-2 Inhibitor (SGLT2 Inhibitors)

Question 16

class: Pramlintide

Answer 16

Amylin Analog

Question 17

class: Liraglutide

Answer 17

GLP-1 (Glucagon-Like-Peptide)Receptor Agonists

Question 18

class: dulaglutide

Answer 18

GLP-1 (Glucagon-Like-Peptide)Receptor Agonists

Question 19

class: semaglutide

Answer 19

GLP-1 (Glucagon-Like-Peptide)Receptor Agonists

Question 20

which class?
stimulate glucose-dependent insulin release from beta cells
o Suppresses glucagon secretion – glucagon is inappropriately released by diabetics
o Slows gastric emptying, reduces postprandial glucagon, increases satiety

Answer 20

GLP-1 (Glucagon-Like-Peptide)Receptor Agonists

Question 21

which class?
slows gastric emptying, promotes satiety, suppresses abnormal postprandial rise of glucagon

Answer 21

Amylin Analog

Question 22

which class?
Inhibits glucose reabsorption in proximal tubule of kidneys

Answer 22

SGLT2 inhibitors

Question 23

which class?
blocks breakdown of GLP-1, increases endogenous GLP-1. which stimulates insulin secretion and suppresses glucagon secretion

Answer 23

DPP-4 inhibitors

Question 24

PPARg agonist, increase GLUT-4 transporters, increase insulin sensitivity of tissues. decrease gluconeogenesis

Answer 24

Thiazolidinediones (Glitazones)

Question 25

which class?
reduces liver gluconeogenesis and glycogenolysis
o Decreases liver glucose formation/release
o Increase glucose uptake by skeletal muscle and adipose tissue, increases insulin sensitivity
Decrease intestinal absorption of glucose

Answer 25

biguanides (metformin)

Question 26

which class?
blocks ATP sensitive K channels, insulin release from functional beta cells. decreased efficacy w/ time
o Increases insulin secretion even w/o eating

Answer 26

Sulfonylureas

Question 27

which class?
MOA: blocks ATP sensitive K channels in beta cells, stimulate/enhance insulin secretion (different site on K channel than sulfonylureas)

Answer 27

Meglitinides

Question 28

which class?
inhibits a-glucosidase in brush border
o delayes absorption of carbohydrates, but does not decrease it

Answer 28

Alpha Glucosidase Inhibitors