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Module 6: Mali: Renal > pharm chart > Flashcards

pharm chart Flashcards

1
Q

what are the 4 thiazides?

A
  1. HCTZ
  2. Chlorthalidone
  3. Metolazone
  4. Indapamide
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2
Q

indications of HCTZ (on and off label!)

A

HTN, edema in nephrotic syndrome; Off-label: Lithium induced diabetes insipidus

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3
Q

MOA of HCTZ

A

Na-Cl symporter inhibition in the DCT increasing Na and Cl excretion max 5% of filtered NaCl

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4
Q

Indications of Chlorthalidone

A

HTN, edema in nephrotic syndrome; off-label: Lithium induced diabetes insipidus

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5
Q

MOA of Chlorthalidone

A

Na-Cl symporter inhibition in the DCT increasing Na and Cl excretion max 5% of filtered NaCl

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6
Q

indications of Metolazone

on and off label

A

HTN, edema in nephrotic syndrome; Off-label: Lithium induced diabetes insipidus

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7
Q

MOA of Metolazone

A

Na-Cl symporter inhibition in the DCT increasing Na and Cl excretion max 5% of filtered NaCl

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8
Q

indications of Indapamide

A

HTN, edema in nephrotic syndrome, HF; Off-label: Lithium induced diabetes insipidus

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9
Q

MOA of Indapamide

A

Na-Cl symporter inhibition in the DCT increasing Na and Cl excretion max 5% of filtered NaCl

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10
Q

what are the three loop diuretics?

A
  1. Furosemide
  2. Torsemide
  3. Ethacrynic Acid
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11
Q

Indications of Furosemide

A

Edema sec to CHF, Renal Failure, Liver Failure

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12
Q

MOA of loops?

A

Inhibits Na+-K+-2Cl- symporter in TAL of Loop & distal tubule

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13
Q

indications of Torsemide

A

edema of cardiac, renal, hepatic failure; HTN

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14
Q

indications of Ethacrynic Acid

A

Edema secondary to CHF, Renal Failure, Liver Failure

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15
Q

2 Aldosterone antagonist, K+ Sparing Diuretic

A
  1. Spironolactone

2. Eplenerone

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16
Q

indictions of Aldosterone antagonist, K+ Sparing Diuretic

A

Edema from excess aldosterone secretion, hypokalemia; heart failure

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17
Q

MOA of Spironolactone and Eplenerone

A

Competitive antagonist at aldosterone mineralocorticoid receptors in DCT increasing NaCl and water loss but retention K

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18
Q

what is the drug class of Amiloride

A

Diuretic, K+ Sparing

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19
Q

Indications of Amiloride

A

Hypokalemia, edema sec to CHF, cirrhosis

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20
Q

MOA of Amiloride

A

Direct inhibitor of Na+ influx in DCT & CCT

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21
Q

drug class of Triamterene

A

Adjunct -K+ sparing

22
Q

indications of Triamterene

A

Hypokalemia

23
Q

MOA of Triamterene

A

Direct inhibitor of Na+ influx in DCT & CCT

24
Q

Drug class of Mannitol

A

Osmotic diuretic

25
Q

indications of Mannitol

A

Reduction of intracranial or intraocular pressure, rhabdomyolysis

26
Q

MOA of Mannitol

A

Osmosis producing increased water loss

27
Q

what drug is a Carbonic

Anhydrase Inhibitors

A

Acetozolamide

28
Q

indications of Acetozolamide

A

Glaucoma, Altitude Sickness

29
Q

MOA of Acetozolamide

A

Reversibly blocks carbonic anhydrase in PCT maintaining NaHCO3 in tubule lumen resulting in diuresis

30
Q

which drug is a
Nonhormonal regulators of mineral homeostasis
“phospate binding agent”

A

Sevelamer

31
Q

indications of Sevelamer

A

Hyperphosphatemia

32
Q

MOA of Sevelamer

A

Non-absorbed phosphate binder prevents absorption promoting excretion

33
Q

Nonhormonal regulators of mineral homeostasis
“calcium based phosphate binders”
which drug is in this class?

A

CaCO3

34
Q

indications of CaCO3

A

CKD with hyperphosphatemia

35
Q

MOA of CaCO3

A

bind to phosphorus in GI tract and excreted

36
Q

What drug is under the class……Nonhormonal regulators of mineral homeostasis
“calcimetric”

A

Cinacalcet

37
Q

indications of Cinacalcet

A

Elevated serum PTH, Ca+, Ca-P product

38
Q

MOA of Cinacalcet

A

Reduces PTH secretion by sensitizing PT gland Ca+ receptors (‘mimics’ the action of Ca+ at receptor) lowering Ca+ and phosphorus levels

39
Q

What drug is under the class……Nonhormonal regulators of mineral homeostasis
“activated vitamin D”

A

Calcitrol

40
Q

indications of Calcitrol

A

Reduction of PTH levels; hypocalcemia in ESRD

41
Q

MOA of Calcitrol

A

Up-regulates Vit D receptor on PT gland decreasing gland hyperplasia and PTH synthesis

42
Q

what is the drug class of Erythropoetin

A

Erythropoesis Stimulants

43
Q

indications of Erythropoetin

A

Anemia in CKD

44
Q

MOA of Erythropoetin

A

Stimulates erythroblasts to proliferate and differentiate into normoblasts, then reticulocytes

45
Q 
which drug is under the class Magnesium supplement
ELECTROLYTE
A

MgCL

46
Q

indications of MgCL

A

Hypomagnesemia

47
Q

MOA of MgCL

A

Supplement

… well that was easy ;)

48
Q

which drug is a
Potassium supplement
ELECTROLYTE

A

KCL

49
Q

indications of KCL

A

Hypokalemia

50
Q

MOA of KCL

A

Electrolyte Supplement

51
Q

what are 6 drugs that have significant renal impact?

A
  1. Furosemide
  2. NSAIDS
  3. ACEIs
  4. ARBs
  5. Cyclosporine
  6. Ionic contrast agents

Module 6: Mali: Renal (4 decks)

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