Pharm Ch. 1: Principles of Pharmocology Flashcards
Relevance of pharm in rehabilitation
Knowing what drugs the pt is taking can help optimize treatment outcomes.
-what they are taking and how it affects them can help with timing treatment and mitigating adverse effects
Pharmacotherapeutics
The use of specific drugs to prevent, treat, or diagnose a disease
Pharmacokinetics
How body absorbs, distributes, and eliminates the drug
Pharmacodynamics
Mechanisms on body
Generic drugs
-Typically less expensive, should be safe and effective but should undergo tests for bioequivalence
-Might result in higher costs because of it having adverse or decreased effects
Orphan drugs
Created for a small population of people with rare diseases. Expensive
Off-label prescribing
-Using a drug to treat conditions other than what it was originally approved to treat
-Insurance companies might refuse to reimburse
-Providers can get in more trouble if PT shows adverse effects
OTC Drug
-Used for minor issues, chances of adverse effects are very small when used correctly
-Usually less expensive
OTC Drug Cons
-Out of pocket cost might be higher
-Can interact with rx medications
-Can delay the use of more effective medications
-PT should not prescribe, but can educate
Modify one or more functions in a living organism to
-Restore normal physiological function
-To prevent disease from occurring
Potency
More potent drug requires a lower dose to produce same effect (not necessarily more effective)
Quantal Dose-Response Curve
% of population that exhibits a specific response as the dose increases
Median Effective Dose
50% of population responds to drug in specified manner
Median Toxic Dose
50% of population exhibits adverse effect
Therapeutic Index
Median toxic dose/median effective dose
Higher=safer
Much larger dose required to evoke toxic response than beneficial one
