Pharm: Cardio Flashcards
Alpha Blocks MOA
antagonizes peripheral alpha-1 adrenergic receptors
What are the first line meds uses for AA w/HTN?
- Diuretics (Thiazide - HCTZ)
- Calcium Channel Blocker
Alpha Blockers: Cautions
- NO pregnancy & hypotension if used w/ Sildenofil (Viagra)
List Alpha Blocker Meds
- Prazosin
- Terazosin
- Doxazosin
- Tamsulosin
Alpha Blockers work mostly in:
- vascular SM
- bladder neck
- prostate gland
If a patients has a sulfa allergy, what should you avoid & what should you use?
- avoid HCTZ
- uses CCB
Prazosin: Uses
-HTN
- BPH
- Nightmares, PTSD
Terazosin: Uses
- HTN
- BHP
Doxazosin: Uses
- HTN
- BPH
Tamsulosin: Uses
- BPH
- nephrolithiasis
When do you take Prazosin?
1st dose at bedtime
When do you take Terazosin?
@ bedtime
When do you take Doxazosin?
@ bedtime
When do you take Tamsulosin?
30 mins after eating in the morning
Tamsulosin: Common Rxns
- abnormal ejaculation
- dizziness
- Rhinitis
- Cough
Beta Blockers are located where & causes what?
- cardiac nodal tissue (Incr CO)
- conducting system (decr HR)
- contracting myocytes (reduce contractility)
BB: Relative Contraindications
- Asthma & COPD (especially non-selective Beta Blockers–>Carbetalol)
- Cocaine Use
- Diabetes Mellitus
BB: Absolute Contraindications
Bradycardia or heart block
List the 1st gen non-selective BB
- Propranolol
- Timolol
List the 2nd gen selective B1B
- Atenolol
- Metoprolol
List the 3rd gen non-selective B & A1 Blocker)
Non-selective
- carvedilol
- Labetalol
List BB meds
- Atenolol
- Metoprolol
- Propranolol
- Carvedilol
- Labetalol
BB: Cautions
- avoid abrupt discontinuation can cause rebound tachycardia
- DON’T USE in 2nd/3rd degree AV block, decomp HF, sinus brady
List the selective antagonist for B1 adrenergic receptor meds
- Atenolol
- Metoprolol
Atenolol: Uses
- HTN
- Angina
- CV event, prevention, post MI (2ndary)
- migraine HA, prophy
Metoprolol: Uses
- HTN
- Angina
- CHF
- *migraine HA prophy
Consider giving a BB if a NEW diastolic murmur to decr pulsatile flow in case of a potential aortic dissection “tearing chest (or back) pain”
List the non-selective antagonist for B1& B2 adrenergic receptor meds
- Propranolol
- Carvedilol
Propranolol: Uses
- HTN
- Angina
- CV prevention, post-MI
- AFib/flutter
- supraventricular arrhythmias
- migraine HA prophy
- essential tremor
- idiopathic hypertrophic subaortic stenosis (IHSS)
- pheochromocytoma, adjunct tx