Pharm cardiac 2

Question 1

Aldosterone Antagonists: Spirinolactone and Eplerenone

Answer 1

MOA: Block Aldosterone receptors in the heart and vessels Diuresis: off load small amt. of volume
Normally- Role of Aldosterone in Heart Failure…can be harmful
Promote renal retention of sodium and water
Promote myocardial remodeling => worsens HF
Promote myocardial fibrosis =>dysrhythmia

By blocking: Reduce Na and water retention , decrease volume
Counteract loss of potassium
Can reduce symptoms and decrease hospitalization
ADR:Hyperkalemia
Care if used with ACEi

Current guidelines suggest adding Aldosterone Antagonists to patient with persistent symptoms despite adequate treatment with ACEI, BB and Diuretic