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pharm antibiotics Flashcards

1
Q

what are the 3rd gen cephlasporin?

A

triax, tax, taz

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2
Q

which of 3rd gen ceph are oral?

A

cefdinir and cefpoxime

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3
Q

what 2nd gen ceph is PO

A

cefuroximine azetil

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4
Q

what 1st gen ceph is po /oral and what 1st gen is IV

A

cephalaxine oral, cefazolin IV

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5
Q

are cephlasporins Beta lactams? similar adverse effects?

A

yes. yes.

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6
Q

Cephlasporins work how?

A

bind to PBP, CELL WALL falls

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7
Q

what allergy is the most common type of allergy among antibiotics/antimicrobials

A

penicillin

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8
Q

can a patient with a PCN allergy get another Beta lactam, names?

A

yes. ceph, carb, monopen

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9
Q

True PCN allergy, give Nafcillin or Oxacillin (anti-staph PCN) or a cephlasporin?

A

no. a cephlasporin (good chance it would be ok)

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10
Q

penicillin ases address how?

A

add beta lactam inhibitors

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11
Q

cephlasporins are __ against beta lactams?

A

stable.

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12
Q

are cephlasporins safe for kids?

A

yes except one.

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13
Q

Pip/tazo, does this get into the CSF? If infected with Pseudomonas, would you want this antimicrobial?

A

no. no.

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14
Q

If CNS/CSF/Pseudomonas infection, tx with Tazo/Pip or later gen Cephlasporins??

A

tazo/pip=x csf, later gen ceph goes to CSF! Maybe carbapenam.

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15
Q

which ceph =x req renal dosing?

A

ceftriaxone.

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16
Q

Cephlasporins have NO activity against ?

A

LAME OR MALE,

LISTERIA, ATYPICALS,

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17
Q

Listeria drug of choice

A

amoxicillin and ampicillin

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18
Q

Do betalactams cover atypicals??

A

Nope. they are CLam.

Chlamydia, Listeria, Mycoplasma

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19
Q

Cephlasporins have NO activity against ?

A

LAME OR MALE,

LISTERIA, ATYPICALS, mrsa (except ceftaroline), Enterococcus

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20
Q

amoxicillin and ampicillin

A

Listeria, enterococus

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21
Q

what one beta lactam covers MRSA?

A

Ceftaroline

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22
Q

w/PCN allergy and LAME bug, can cephlasporins be used?

A

NOPE, no coverage for LAME, lysteria/atypicals (chlyamidyia, mycoplasma)

23
Q

what is 1st gen ceph use for?

A

MSSA! G+ !!

24
Q

what is 3rd gen ceph used for

A

(G+) Strep Pneumo!!! (some G - )ECOLI!

25
Q

when use 6th gen ceph?

A

when can’t use carbapenems (CRE) ?

26
Q

1st gen ceph and anti staph are both D.O.C for ?

A

staphlococcus : MSSA

27
Q

what is the drug of choice for staph: MSSA?

A

1st gen ceph (cef and anti staph PCN (amox, Amp)

28
Q

group A strep (strep throat) start with a ___, but if allergy, what can be used?

A

PCN (amoxicillin), allergy then can do a 1st gen ceph ( cephalexin, or cefazolin)

29
Q

which gen ceph for strep pnemonia

A

3rd

30
Q

what is PEK

A

proteus

31
Q

Antistaph and 1st gen ceph are drug of choice for what? which is preferred?

A

MSSA, 1st gen ceph preferred (last longer, less side effects)

32
Q

mssa infection what IV agent recommend for pt with mild non anaphalactic PCN allergy

A

cefazolin

33
Q

2nd gen ceph, which is oral and is it not

A

cefuroximide oral

34
Q

3rd gen cephlasporin oral agent

A

cefdinir, also cefpodomire

35
Q

3rd gen. ceph coverage and what is designed for

A

resist b lactam ace ,

36
Q

what 3rd gen ceph dose 1x day

A

ceftriax

37
Q

what 3rd gen issue w kids and which?

A

ceftriaxone, kernicteris

38
Q

what 3rd gen issue w kids and which?

A

ceftriaxone bound to albumin in kidneys, kernicteris

39
Q

which ceph =x req renal dosing? how many dose per day?

A

ceftriaxone, one (unique)

40
Q

what does ceph triaxe cover and not cover

A

pek+h+m+space (no pseudo), tc Ghonorea

41
Q

ceftriaxone can be use for s pnemoniae?

A

yes

42
Q

What is metronidazole used for?

A

anearobes G+ and G-

43
Q

what cephazolins add metro to for anaerobic coverage?

A

cephapine, cefazolin, ceftriaxone

44
Q

does pip/tazo need additional coverage with metronidazole?

A

no

45
Q

what cephasolins could benefit from metronidazole? also

A

1st or second generation cephlasporin

46
Q

add metro to these to treat anearobes in gut

A

floroquinilones: ciprofloxin, levoflox

47
Q

metronidazole + tinidazole together treats what?

A

protozoa and parasites: trichomonas, gardinerella, entamoeba

48
Q

drug interaction with Metronidazole with ___ product then ___ what happens?

A

alcohol (dinatab or robotussin or alcohol) to disulferam –>N/V/flushing and cardiac.no aclcohol on the metro

49
Q

metronidazole drug of choice

A

trichomonas vaginialis, also for aneorobes.

50
Q

clindamycin can be taken how?

A

every way. bac stat

51
Q

aneorobic bacterias

A

bateroides, fusobacterium, provetella, clostridium, actinomyces, lactobacillis, proprionibacterium, pepto & peptostrepto

52
Q

metro or clinda for csf?

A

metro. clinda =x brain

53
Q

what can metro not treat?

A

no staph no strep. metro aneorobes.

pharm (2 decks)

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