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ENDOREPRO II Exam I > [PHARM] Antenatal and Perinatal Pharmacology [Wolff] > Flashcards

[PHARM] Antenatal and Perinatal Pharmacology [Wolff] Flashcards

1
Q

What is the drug used for?

Misoprostol

A

Induction of labor

&

Control post-partum bleeding

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2
Q

What is the drug used for?

Dinoprostone

A

Induction of labor

&

Post-partum bleeding

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3
Q

What is the drug used for?

Carboprost

A

Induction of labor

&

Control of post-partum bleeding

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4
Q

What is the drug used for?

Oxytocin

A

Induction of labor

&

Control post-partum bleeding

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5
Q

What is the drug used for?

Ergot alkaloids

A

Induction of labor

&

Control post-partum bleeding

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6
Q

What is the drug used for?

Terbutaline

A

Delay labor

(tocolytics)

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7
Q

What is the drug used for?

Nifedipine

A

Delay labor

(tocolytics)

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8
Q

What is the drug used for?

MgSO4

A

Delay labor

(tocolytics)

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9
Q

What is the drug used for?

Atosiban

A

Delay labor

(tocolytics)

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10
Q

What is the drug used for?

Alprostadil

A

Maintain patent ductus arteriosus

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11
Q

What is the drug used for?

Indomethacin

A

Delay labor (tocolytic)

AND

CLOSE patent ductus arteriosus

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12
Q

What is the drug used for?

Ibuprofen

A

CLOSE patent ductus arteriosus

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13
Q

What is the drug used for?

Alpha-methyldopa

A

Anti-hypertensive in pregnancy

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14
Q

What is the drug used for?

Labetalol

A

Anti-hypertensive in pregnancy

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15
Q

What is the drug used for?

Hydralazine

A

Anti-hypertensive in pregnancy

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16
Q

What is the drug used for?

Sodium nitroprusside

A

Anti hypertensive in pregnancy

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17
Q

What are the (3) corticosteroids?

A

Cortisol

Bethamethasone

Dexamethasone

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18
Q

What are key prostaglandins involved in uterine myocyte RELAXATION?

A

CRH

B2 sympathomimetics

Prostaglandin E2

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19
Q

What are key prostaglandins involved in uterine myocyte CONTRACTION?

A

Oxytocin

Thrombin

Prostaglandin F2alpha

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20
Q

Describe what is occuring during cervical ripening

A

Initially, the cervix contains a densely packed collagen fiber plug that prevents the fetus from leaving the uterus

During cervical ripening, the plug becomes loosely associated

21
Q

What are the drugs that are used to stimulate the uterus called?

22
Q

MOA of misoprostol?

A

Prostaglandin E1 analog

23
Q

Clinical indications for misoprostol?

A
  • Termination of intrauterine pregnancy
  • OFF LABEL = cervical ripening
24
Q

Contraindications of misoprostol

A

Pregnancy (unless aborting)

Previous cesarean delivery (disrupts uterine scar leading to rupture)

25
Q

AE of misoprostol?

A

MATERNAL = N/V, chills, shivering, Tachysystole

FETAL= hypoxia due to prolonged uterine contractions

26
Q

MOA of dinoprostone?

A

Prostaglandin E2 analog

27
Q

Clinical indications for dinoprostone?

A

Cervical ripening

Induction of labor

28
Q

Contraindications for dinoprostone?

A

Pregnancy (unless aborting)

Previous cesarean delivery (disrupts previous uterine scar)

29
Q

Maternal AE for dinoprostone?

A

N/V, fever, chills

During abortion, fever unresponsive to NSAIDS

30
Q

Fetal AE of dinoprostone?

31
Q

MOA of carboprost?

A

Prostaglandin F2alpha analog

32
Q

Indications for carboprost?

A

3rd line treatment for

Inducing abortion

and

Post-partum hemostasis for refractory bleeding

33
Q

Important to note about Maternal AE of carboprost?

A

TONS of AE, pt will feel awful after taking

Hypertension, pulmonary edema, chills/shivering, dizziness, gagging, heartburn, etc…

34
Q

MOA of oxytocin?

A

Posterior pituitary hormone

35
Q

Clinical indications of oxytocin?

A

Induction of labor

36
Q

AE of oxytocin?

A

Water intoxication (rare)

37
Q

Contraindications for oxytocin?

A

DO NOT INDUCE LABOR IF…

Lungs are not mature

or

Cervix is NOT RIPE

38
Q

What is the historic drug used to induce labor?

A

Ergot alkaloids

39
Q

What is the issue with using ergot alkaloids?

A

Causes prolonged tonic uterine contraction

CONSTRICTS aterioles and veins

40
Q

What are two conditions that would warrent pre-term delivery?

A

HELLP (hemolysis, elevated liver enzymes, low platelet count)

Pre-eclampsia

41
Q

What is the function of fetal cortisol?

A

Drives lung maturation

42
Q

What are the two options to give to drive fetal lung maturation?

A

Bethamethasone

Dexamethasone

43
Q

What is magnesium sulfate used for?

A

Prevents eclamptic seizures

44
Q

MOA of terbutaline?

A

Beta2 agonist

45
Q

MOA of nifedipine?

A

Calcium channel blocker

46
Q

What are the BEST choices to use as a tocolytic in the USA?

A

Nifedipine

Indomethacin

47
Q

MOA of alprostadil?

A

Synthetic PGE1

ENDOREPRO II Exam I (26 decks)

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