[CLMD] Obstetric Complications [Wootton] Flashcards
What are some nonmodifiable risk factors for Preterm Labor (PTL)?
Socioeconomic Factors – African Americans
Medical and Obstetrical Factors:
Previous HIstory of PTL
History of 2nd trimester abortion
Repeated Spont 1st trimester abortion
bleeding in 1st trimester
UTI
Twins
Uterine Abnormalities
Polyhydraminos
What are some modifiable risk factors of PTL?
Infection
Placental-Vascular
Pyschosocial Stress/Work Strain
Uterine Stretch
What associations are we considering with Infection/Cervical pathway in terms of modifiable risk factors of PTL?
Bacterial Vaginosis
Tx for Group B Strep
Tx for Gonorrhea/Chlamydia
In terms of cervical length how does it correlate with PTL?
As Cervical Length DECREASES; PTL INCREASES
Assess with Ultrasound, or Fetal Fibronectin (FFN)
What are the 3 components to the Placental-Vascular Pathway?
Immunological Component
Vascular Component
Low Resistance connection of Spiral A
(Alteration of either of these, results in poor fetal growth –> PTL)
What are the main hormones released in the Stress-Strain pathway that we can help to reduce?
Cortisol
Catecholamines
Uterine Stretch pathway is a result of increasing volume, and is a risk factor in what 2 things?
Polyhydraminos
Multiple Gestations
When & How do we diagnose PTL?
What symptoms are expected?
20-37 weeks w/ a CERVICAL EXAM, External Monitoring, FHR
Must have: Uterine Contractions, Cervical Dilation of 2cm (80% effacement)
Menstraul like cramping, Backache, Pelvic Pressure, Discharge (bloody), Uterine Contractions
Once you have done the initial assessment, and before you can confirm PTL, how do you manage the patient?
Reevaluate Cervix after an hour
Oral/IV Hydration
Bed Rest
Cultures Taken –> for Group B Strep
Ultrasound
Once you have DIAGNOSED PTL, how do you manage the patient?
Begin Tocolysis (MgSO4, Nifedipine, or Indomethacin)
also give Steroids if the baby is preterm (for Lung Growth)
What is the benefit of giving MgSO4?
Neuroprotection, (against Cerebral Palsy)
(MgSO4 is given if less than 32 weeks)
What are the benefits of giving Nifedipine for Tocolysis of a PTL patient?
Its an Oral agent
Minimal Maternal and Fetal Side affects
(replacing Mg as drug of choice)
What are the benefits/risks of giving Indomethacyin (Prostaglandin Synthetase Inhibitors)?
Inhibits Prostaglandin –> induce myometrial contractions
Can be given ORAL or RECTAL
Can result in Oligohydraminios
Can cause premature closure of Fetal DA –> Pul HTN –> HF
Necrotizing Enterocolitis, Intracranial Hemorrhage
What drug is not used for primary tx of preterm labor, but is shown to decrease uterine activity?
NSAIDS
When do you give Glucocorticoids (Betamethasone)?
For Fetal Lung Maturation
(given between 24-34 weeks) – lasts 7 days