PHARM (A-F) Flashcards
What is the indication of 5-fluorouracil?
Cancer (breast cancer, topical for basal cell carcinoma)
What are top SE of 5-fluorouracil?
CNS damage, toxic, dermatitis
What is acetaminophen used for?
Mild to moderate pain
What is an antidote for acetaminophen?
N-ACETYL-cysteine
What is the indication for acyclovir?
ANTI-VIRAL: Varicella, herpes zoster, genital herpes
What is the indication of adalimumab?
RA, AS, Crohn’s, psoriasis
What is the MOA for adalimumab?
Down regulates inflammatory rx in auto-immune diseases. It is a TNF-alpha deactivator
What are some SE of adalimumab?
Nausea/injection site rx/opportunistic infx, URTI, abdominal pain, lymphoma
What is the indication for adefovir?
Hep B and HSV
What is the MOA of adefovir?
Blocks reverse transcriptase, an enzyme crucial for HBV to reproduce in the body.
What are some SE of adefovir?
May cause kidney damage, liver damage
Albuterol is used for asthma and COPD. What is the difference between salbutamol vs. salmeterol?
Salbutamol: SHORT acting Beta2-agonist
Salmeterol: LONG acting (slower onset)
What is the indication for alendronate (fosamax)?
Osteoporosis
What is the SE of alendronate (fosamax)?
Rare: esophageal strictures, renal impairment, hypocalcemia, atypical fractures
What is the MOA of alendronate?
Inhibits osteoclast bone resorption.
Bisphosphonate drug
What is the indication of alprazolam (Xanax)?
Anxiolytic, insomnia
What is the indication for amantadine?
Influenza A - blocks viral acidification and release of RNA into cytoplasm
Parkinson’s disease (helps levodopa-induced dyskinesia in later stages)
Off label for MS
What are some SE of amantadine?
Agitation, hallucination, leg edema, erythema, livedo reticularis (reddish blue skin pattern - most common)
What is the indication for amiodarone?
Arrhythmia (ATRIAL FIB, vent fib/vent tach)
HF with arrhythmia
When is amiodarone CI?
Use of lidocaine, severe sinus-node dysfunction, 2nd and 3rd degree AV block, syncope
What is the indication for amitriptyline?
Tri-cyclic antidpressant (major depressive disorder)
What are some AE of anticholinergic activity of amitriptyline?
Dry mouth/dizziness/tremor/blurred vision
Which herb does amitriptyline interact with?
Belladonna/hyoscyamus/datura
What are some AE of amitriptyline?
Sexual function, antihistaminergic (Sedation/weight gain), orthostatic hypotension in elderly
What is the indication of amlodipine?
HTN, calcium channel blocker
What is the indication for amoxicillin?
B-lactam antibiotic used for infections/osteomyelitis
(strep/sinusitis/pneumonia/UTI/chlamydia/OM)
SE of amoxicillin
N +V, rash, colitis, GI,
decreases efficacy of OCP
increases methotrexate levels
Anastrazole indication
Breast cancer
Anastrazole MOA
Aromatase p450 inhibitor, reduce estrogen, inhibits conversion of androgen to estrogen in peripheral tissue
Anastrazole SE
Bone weakness
Androstenedione indication.
NEVER. Drug of abuse, anabolic steroid (testosterone deficient)
Aspirin SE
GI issues
Reye’s syndrome in children (liver failure/edema/death)
Atenolol/propanolol indication and MOA
HTN
B-blocker
Atenolol/propanolol SE
Dizzy/lightheaded/tired/drowsy/depressed
Rare: hyperglycemia/depression/HF
What do you need to monitor when prescribing atorvastatin?
Liver function every 3 months
Atorvastin AE
Increased CK, mild upper GI disturbance, sleep issues, headache, rash
MYOPATHY, COQ10 depletion
Rare: periph neuro, impotence
Atorvastatin MOA
HMG-CoA reductase inhibitor
Atropine indication
Glaucoma, bradycardia, can manage cholinergic sx and acute diarrhea
Atorvastatin indication
Primarily lowers LDL
Prevention of CAD
MOA of atropine
mACh R antagonist (ocular and GI)
Parasympathetic inhibitor - dilates pupil, increase HR, reduce salivation
Azithromycin indication.
Infections - AOM, pneumonia, PID, traveller’s diarrhea
Effective against GRAM-NEGATIVE
Bisacodyl indication
Laxative (stimulant) for constipation
Possibly for pts on long-term opioid therapy
Bismuth subsalicylate indication
Antacid, anti-diarrhea
Bismuth subsalicylate SAFETY
Avoid in preg, can lead to increase perinatal mortality
Bromocriptine indication
Adjunct to PD, hyperprolactinemia, T2DM, amenorrhea, infertility
Bromocriptine MOA
Dopamine agonist
Bromocriptine SE
N+V, hypotension, hallucinations, psychosis,
erythromelalgia (burning/redness of extremities)
Bupropion indication (wellbutrin)
Depression, anxiety, SMOKING cessation
Bupropion SE
Does not cause weight gain or sexual dysfunction.
Otherwise, similar to anti-depressants (agitation, insomnia,
anorexia)
Bupropion CI
Eating disorder
Buspirone indication
GAD – the drug most other drugs are compared to when
trying to establish effectiveness
Buspirone SE
Nausea, headache, dizzy, restlessness
Capsaicin indication
Irritant used topically to reduce pain, pruritis
Capsaicin MOA
Reduce substance P (sensory nerve for pain)
Analgesic, TRPV1 agonist
Carbamazepine indication
Anti-convulsant
Seizures/epilepsy
Mania/bipolar