Pharm Flashcards
Lipitor / atorvastatin
Hmg/coa reductase inhibitor. Blocks production of cholesterol
What supplement should be taken with atorvastatin which causes coenzyme depletion up to 50% within 30 days
100mg CoQ10. 10 to 30mg can prevent initial decline.
What medication interferes with atorvastatin absorption
Magnesium and aluminum containing antacids. Take lipitor 2 hours before or after any antacids.
Niacin is ..
Vitamin b3. Used to lower cholesterol.
Niacin taken along with ___ can cause myopathy (muscle disorders) amd can enhance cholesterol lowering effects.
Hmg-coa reductase inhibitors.
Vitamin a blood levels increased over time when used with ___. People who take ___ should get blood work monitored if they intend to supplement with vitamin a.
Hmg-coa reductase inhibitors
Prilosec / omeprqzole
Proton pump inhibitor. Blocks production of stomach acid.
Folic acid is needed by the body to utilize ___
Vitmin b12
what medication inhibits absorption of folic acid?
Antacids
People taking antacids are advised to supplement with ___
Folic acid
Omeprazole interferes with the absorption of ___ from food (not suppliments)
Vitamin b12
The fall of vitamin b12 status may result from ___
The decrease in stomach acid required for vitamin b12 absorption from food caused by the drug (antacids, omeprazole etc)
People taking omeprazole and related antacids should ___
either take a vitamin b12 supplement or get levels checked yearly
10 to 50mg per day of vitamin b12 can __
Protect against drug induced vitamin depletion
What suppliment decreases omperazole blood levels by accelerating the drugs metabolism?
St. Johns wort
People taking omperazole may increase absorption of ____ by drinking ____ or other acidic liquids with _____ containing foods.
Vitamin b12, cranberry juice, vitamin b12
Montelukast
LTRA - leukotriene receptor antagonist used to treat asthma and allergies
Lansoprazole
Proton pump inhibitor
Omeprazole and lansoprazole taken for several days led to a near - total loss of ___ in healthy people and interfered with the ___ of a single administration of 120mg of beta-carotene.
Stomach acid, absorption
What blood levels should be checked for people taking acid-blocking drugs for long periods of time
Carotenoid blood levels
What recommendation should you give for people taking acid blocking medications
Eat plenty of fruits and vegetables and consider supplementing with carotenoids
Folic acid is needed by the body to ____
Utilize vitamin b12
What to antacids inhibit?
Folic acid absorption
People taking antacids should suppliment with ___
Folic acid
Lansoprazole dosing
30 minutes before a meal dame time every day.
Venlafaxine
Depression
L-tryptophan
Essential amino acid, serotonin precursor, biosynthesis of protein. Must be obtained from diet.
5-HTP (hydroxytryptophan)
Serotonin reuptake inhibitor, amino acid. Converts protein to serotonin in the brain.
Venlafaxine with what SRI / herbs should be avoided.
5-hydroxytryptophan, L-Tryptophan, St. Johns wort, sour date nut.
Why is 5-HTP better than L-Tryptophan
Crosses blood brain barrier at higher rate, converts serotonin more efficiently with stronger effects.
What is serotonin syndrome
Over production of serotonin because of a medication or combo of meds. Extreme nerve cell activity.
When to take Valsartan
Ingestion of food woth valsartan may decrease the maximum blood level of the drug by %50 therefore should be taken an hour before or two hours after a meal.
Crestor - rosuvastatin
Reduce cholesterol and fat levels in the blood and to increase HDL (good cholesterol) levels. Class - HMG-CoA reductase inhibitor.
Niacin and crestor
High doses of niacin (higher than normal nutritional suppliment doses) isn’t recommended to take with crestor because of increased risk of rhabdomyolysis and kidney damage. Greater risk in elderly or if preexisting kidney damage.
Simvastatin
HMG-CoA reductase inhibitor blocks bodys production of cholesterol. Lower elevated cholesterol reduces risk of heart attack / death
