Pharm Flashcards
What is Mupirocin’s MOA?
Inh isoleucyl-tRNA synthetase > inh protein synthesis
Topical ATBs for acne have what MOA?
Inh 50S > inh protein synthesis
What ATB/s have a MOA involving inh 30S?
Gentamycin
Neomycin
What’s the risk of Erythromycin?
Resistance dev
What ATB is used to tx Impetigo?
Mupirocin
Allyamines are used to tx tinea fungal infections, by what MOA?
Inh of squalene epoxidase, a key enzyme in ergosterol synthesis
What med is definitely not used to tx Candida infections?
Tolnaftate (Tinactin)
What drug is great for attacking dermatophyte infections of the nails (onychomycosis)?
Terbinafine (because it accumulates in skin, nails, and fat)
What’s the MOA of Griseofulvin? What class of drugs does it fall under? What does it NOT tx?
Inh fungal cell mitosis at metaphase by binding keratin and making it resistant to fungal invasion
Oral anti-fungals
Candida infections
Antivirals work by what MOA?
Converted to active triphosphate metabolites that inh viral DNA and RNA synthesis
What’s Imiquimod used for?
Warts, actinic keratoses, BCC
What’s the SE of Isotretinoin?
Hypervitaminosis A (dryness of skin and pruritis)
What metabolite is teratogenic regarding Acitretin?
Etretinate (Acitretin + ETOH)
What drugs are used for psoriasis?
MAC (methotrexate, Acitretin, Cyclosporine)
ATU (Alefacept, TNF-inh, Ustekinumab)
What enzyme does Fluorouracil act on?
Thymidylate synthetase
