Pharm

Question 1

what is the main moa of COCs

Answer 1

inhibit ovulation

alter the lining of endometirum

Question 2

what does progestin do specifically?

Answer 2

thickens cervical mucus
red. activity of cilia in fallopian tubes
thin the endometrium

Question 3

what is important about POPs?

Answer 3

need to be taken at the same time every day to keep efficacy

*they do not appear to dependently inhibit ovulation

Question 4

what is monophasic COC?

Answer 4

contains the same amount of hormone in each tablet

Question 5

what is the multiphasic COC?

Answer 5

contains varying amount of estrogen and progesterone to try to mimic natural fluctuations

Question 6

what estrogen is most used in COC?

Answer 6

ethinyl estradiol (mestrandol is the prodrug)

Question 7

what is special about drospirenone?

Answer 7

only progesterone with antiandrogenic effects

assoc. w/ higher risk of blood clots

Question 8

which oral contraceptives are monophasic?

Answer 8

extended cycle, continuous and sometimes monthly

Question 9

what drugs interact with COCs

Answer 9

rifampin and ritonavir

Question 10

what do you need to worry about with contraceptives that contain drospirenone like yasmin?

Answer 10

inc. risk for hyperkalemia

Question 11

explain ulipristal?

Answer 11

EC
binds to progestin receptors to delay/prevent ovulation, also makes endometrium hostile
take within 5 days
need a pregnancy test before prescribing (category x)

Question 12

explain levonorgestrel

Answer 12

EC-progestin only
preventing ovulation
will not terminate an existing pregnancy
 3 day window
OTC for > 17 yo

Question 13

what do you use to treat fungal vulvovaginitis?

Answer 13

fluconazole (or any -conazole)

Question 14

who should only use topical fluconazole?

Answer 14

pregnant ladies

Question 15

is clotrimazole an anti fungal?

Answer 15

yes

Question 16

what is the moa of -conazoles?

Answer 16

inhibits ergosterol synthesis making the CM permeable

Question 17

what is the moa of metronidazole and tinidazole?

Answer 17

prodrug that releases free radicals that interact with cell nucleic acids

Question 18

what does metronidazole target?

Answer 18

anaerobic gram - bacterial infections

like b. frag and b. thetaiotamicron

Question 19

what are two indications for metronidazole and tinidazole use?

Answer 19

bacterial vaginosis

trichomonas vaginitis

Question 20

what drug do you use for a chlamydia infection when gonorrhea has been ruled out?

Answer 20

doxycycline or azithromycin

Question 21

what medication do you use to treat genital warts

Answer 21

trichloroacetic acid