Pharm

Question 1

Acetaminophen

Answer 1

M: Reversibly inhibits COX
C: Antipyretic, analgesic, NOT ANTI-INFLAMMATORY
T: Hepatic necrosis, depletes glutathione (N-acetylcysteine regenerates it)

Question 2

Aspirin

Answer 2

M: IRREVERSIBLY inhibits COX (1 and 2)
C: Low dose (decreased platelet aggregation), intermediate dose (antipyretic and analgesic), high dose (anti-inflammatory)
T: Hemolysis in G6PD deficiency, gastric ulcers, tinnitus, Reye syndrome in kids, respiratory alkalosis (switches to mixed metabolic acidossis/respiratory alkalosis)

Question 3

Celecoxib

Answer 3

M: Reversible inhibits COX2 (antiinflmmatory but spares platelet function)
C: Rheumatoid, osteoarthritis
T: SULFA allergy

Question 4

NSAIDs (Ibuprofen, naproxen, indomethacin, ketorolac, diclofenac)

Answer 4

M: Reversibly inhibit COX1 and 2
C: Antipyretic, analgesic, anti-inflammatory
T: Aplastic anemia, interstitial nephritis

Question 5

Bisphosphonates (Alendronat)

Answer 5

M: Inhibit osteoclast activity, pyrophosphate analog
C: Osteoporosis, Pagets, hypercalcemia

Question 6

Teriparatide

Answer 6

M: Recombinant PTH, increase osteoblasts
C: Osteoporosis

Question 7

Allopurinol, Febuxostat

Answer 7

M: Inhibit Xanthine oxidase
C: Chronic gout treatment, prevent tumor lysis syndrome

Question 8

Pegloticase

Answer 8

M: Recombinant uricase to increase uric acid metabolism to allantoin
C: Chronic gout

Question 9

Probenecid

Answer 9

M: Inhibit reabsorption of uric acid in PCT
C: Chronic gout
T: DON’T USE WITH RENAL FAILURE

Question 10

Colchicine

Answer 10

M: Binds/stabilizes tubulin to inhibit microtubule polymerization, impairing neutrophil chemotaxis
C: Acute and chronic gout
T: Diarrhea, myopathy

Question 11

Etanercept

Answer 11

M: Fusion protein (TNF-a decoy receptor)
C: Rheumatoid, psoriasis, ankylosing spondylitis
T: SLE like syndrome

Question 12

Infliximab, Adalimumab

Answer 12

M: Anti-TNF-a monoclonal antibody
C: IBD, Rheumatoid, ankylosing spondylitis, psoriasis
T: Can cause reactivation of TB