Pharm

Question 1

Phenobarbital

Answer 1

hyperactivity in children preoperative sedation GABA agonist

Question 2

Secobarbital

Answer 2

-short term effects -treats acute psychosis (aka combative behavior)

Question 3

Benzo Receptor

Answer 3

GABA-a not actual GABA site GABA needed, binding causes opening of the Cl- channels Allows Body to mediate the response

Question 4

Barbiturates Receptor

Answer 4

Gamma – subunit

Question 5

GABA

Answer 5

Beta subunit

Question 6

Alprazolam (Xanax)

Answer 6

-good for elderly patients -exacerbates pulmonary issues

treats panic disorders

Question 7

benzodiazepines withdrawal. SX. Withdrawal Paradigm

Answer 7

restlessness and anxiety -25% reduction per week until 50% of dosage, followed by reduction by 1/8th dose per week

Question 8

Zolpidem Receptor

Answer 8

-rapid onset, sedative effect -GABA-a type I

Question 9

Zaleplon

Answer 9

-short acting sedative effect (just enough for person to fall asleep) -rapid onset, GABA- a omega 1

Question 10

MOA for Propofol (2,6-diisopropylphenol)

Answer 10

-Stimulates GABA release -not for children

Question 11

Population that etomidate is clinically useful in?

Answer 11

-Elderly, doesn’t reduce blood volume

Question 12

Describe Gabanergic Neurons?

Answer 12

-short interneurons

Question 13

Advantages of Buspirone

Answer 13

No abuse potential, effective for GAD No impairment of cognitive or psychomotor skills

Question 14

Disadvantages Buspirone

Answer 14

Takes few weeks to work NOT for panic disorders

Question 15

Benzodiazepine Side Effects

Answer 15

-interaction with alcohol -dependence/abuse -can’t operate heavy machinery

Question 16

Azapirones/Buspirone Receptor, Effect of Serotonin

Answer 16

Acts of 5HT1A receptors, decreases serotonin

Question 17

Ramelteon Advantages

Answer 17

Acts on melatonin receptors MT1/MT2 No rebound/withdrawal effects

Question 18

Propanolol

Answer 18

Performance anxiety

Question 19

Switch BZ to Buspirone

Answer 19

Requires patient to taper off of BZ in order to switch

Question 20

Lorazepam

Answer 20

GAD: generalized Anxiety Disorders

Question 21

Meprobamate

Answer 21

Short term anxiety/sedative-hypnotic No longer than 4 months

Question 22

3 Sedation Settings

Answer 22

Monitored Anesthesia, Conscious Sedation, Deep Sedation

Question 23

Monitored Anesthesia

Answer 23

regional anesthetic and propofol

Question 24

Conscious Sedation

Answer 24

propofol, verbally responsive

Question 25

Deep Sedation

Answer 25

pts need to help breathing, difficult to arouse

Question 26

Panic Disorder vs GAD

Answer 26

panic is more acute

Question 27

2007 Label for Hypnotics

Answer 27

more serious labels about sleep driving

Question 28

Benzodiazepine for Nocturnally Predominant Pain

Answer 28

Clonazepam