Pharm

Question 1

Typical Antipsychotics (Neuroleptics)

Answer 1

Haloperidol, Trifluoperazine, Fluphenazine, Thioridazine, Chlorpromazine

Question 2

High potency Typical Antipsychotics

Answer 2

Trifluoperazine, Fluphenazine, Haloperidol;

EPS side effects

Question 3

Low potency Typical Antipsychotics

Answer 3

Chlorpromazine, Thioridazine;

anti-cholinergic, anti-histamine, alpha-1 blockade side effects

Question 4

Other side effects of Typical Antipsychotics

Answer 4

Chlorpromazine: corneal deposits;
Thioridazine: retinal deposits;
Haloperidol: NMS, Tardive dyskinesia

Question 5

NMS

Answer 5

Fever;
Encephalopathy;
Vitals unstable;
Enzymes increase
Rigidity of muscles

Question 6

Atypical Antipsychotics

Answer 6

Olanzapine, Clozapine, Quetiapine, Risperidone, Aripiprazole, Ziprasidone;
fewer EPS and anticholinergic side effects than typical antipsychotics

Question 7

side effects of Atypical Antipsychotics

Answer 7

Olanzapine/Clozapine: wt gain;
Clozapine: agranulocytosis, seizure;
Risperidone: increase prolactin (causing lactation and gynecomastia);
Ziprasidone: prolong QT

Question 8

Lithium side effects

Answer 8

tremor, nephrogenic diabetes insipidus, hypothyroidism, Ebstein anomaly

Question 9

SSRIs

Answer 9

Fluoxetine, Paroxetine, Sertraline, Citalopram;

Question 10

SSRIs side effects

Answer 10

GI distress, sexual dysfunction, Serotonin Syndrome w/ any drug that increase serotonin;
tx Serotonin Syndrome: Cyproheptadine

Question 11

SNRIs

Answer 11

Venlafaxine, Duloxetine

Question 12

TCAs (block reuptake of NE and 5-HT)

Answer 12

Amitriptyline, Nortriptyline, Imipramine, Desipramine, Clomipramine, Doxepin, Amoxapine

Question 13

TCAs side effects

Answer 13

sedation, postural hypotension, ANTICHOLINERGIC;
Convulsions, Coma, Cardiotoxicity (arrythmias);
tx cardiotoxicity: NaHCO3

Question 14

MAOIs (blockade increases NE, dopamine, 5-HT)

Answer 14

Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (selective MAO-B inhibitor);

Question 15

MAOIs side effects

Answer 15

hypertensive crisis w/ tyramine ingestion;

contraindicated w/ SSRIs, TCAs, St. John’s wort, Meperidine, Dextromethorphan (to prevent serotonin syndrome)

Question 16

Atypical Antidepressants

Answer 16

Bupropion (increase NE and Dopamine);
Mirtazapine (alpha-2 antagonist increases release of NE and 5-HT) - side effects: wt gain;
Trazodone (blocks 5-HT2 and alpha-1 receptor) - side effects: sedation, priapism

Question 17

Benzodiazepams not metabolized by liver, rather metabolized by Phase II

Answer 17

OTL:

Oxazepam, Temazepam, Lorazepam

Question 18

Short acting Benzodiazepams

Answer 18

Oxazepam, Midazolam, Triazolam;

have potential for dependence and tolerance (more likely than long-acting benzodiazepams such as Diazepam)