Pharm

Question 1

• Hypothryoid pregnant needs?
• Thyroid meds take how long to equilibrate?
• T4 –> T3 in periph blocked by? (3)
• Graves treatment? (3) Drugs? (5)
• Thyroid storm drugs? (4)
• Young with hyper? Old?

Answer 1

• T4 for fetus
• 6-8 weeks
• B-blockers, ipodate, corticosteroids
  1. ) Interfere with prod: Thionamides, Iodides
  2. ) Modify tissues: B Blockers/ Steroids
  3. ) Destroy: RAI
• Propranolol, NaI, PTU, Hydrocortisone
• Pharm; RAI

Question 2

Levothyroxine:

• AKA?
• Half life?
• Ther. Window?

Answer 2

• T4
• Long
• Narrow

Question 3

Liothyronine:

• AKA?
• Half life?
• Risk of? (2)

Answer 3

• T3
• Short
• Cardiac/osteoporosis

Question 4

Liotrix:

• AKA?
• SE?

Answer 4

• 4:1 T4:T3

- Osteoporosis

Question 5

USP:

• AKA?
• From where?

Answer 5

• Variable T3/T4

- Pig extract

Question 6

Methimaxole:

• Drug type?
• MOA? (2)
• High dose?
• SE? (4)

Answer 6

• Thionamides
• Block organo/ coupling
• Lowers periph conversion
• Pruritis, Arthralgias, Hepato, Agranulo

Question 7

PTU:

• Drug type?
• MOA? (2)
• High dose?
• SE? (4)

Answer 7

• Thionamides (Can use in pregnancy)
• Block organo/ coupling
• Lowers periph conversion
• Pruritis, Arthralgias, Hepato, Agranulo

Question 8

Iodides:

• MOA? (3)
• Risk?
• SE? (2)

Answer 8

• Decrease hormone release via high IC iodide, Inhibits TGB proteolysis
• Can make it worse
• Rash, rhinorrhea

Question 9

• GH Pharm:
• Gherlin leads to?
• GH increases? (2)
• Somatostatin/ IGF1?
• Nephrogenic DI can occur with? (3)

Answer 9

• Release of GH
• Insulin/ IGF-1
• Decrease GH
• Li, T2D, NSAIDS

Question 10

• Sermorelin:
• MOA?
• Effectiveness?

Answer 10

• Synthetic GHRH

- Not very

Question 11

• Somatropin:
• MOA?
• Route?

Answer 11

• Recomb. GH stim. IGF1

- IM

Question 12

• Somatrem:
• MOA?
• Route?

Answer 12

• Recomb. GH stim. IGF1

- IM

Question 13

• Mecaserem:

- MOA?

Answer 13

• GH resistant = IGF1 synthetic

Question 14

• Lanreotride:
• MOA?
• Decreases? (4)
• Route?
• Lasting?

Answer 14

• Somatostatin analog
• GH, Glucagon, Insulin, TSH
• Sub Q
• Long

Question 15

• Octeotride:
• MOA?
• Decreases? (4)
• Route?
• Lasting?

Answer 15

• Somatostatin analog
• GH, Glucagon, Insulin, TSH
• Sub Q
• Long
• Short

Question 16

• Bromocriptine:
• MOA?
• Decreases? (2)

Answer 16

• DA receptor agonist

- GH/ PRL

Question 17

• Cabergoline:
• MOA?
• Decreases? (2)
• Preferred?

Answer 17

• DA receptor agonist
• GH/ PRL
• Yes

Question 18

• Demecloclyine:
• MOA?
• Use?

Answer 18

• Blocks vasopressin

- SIADH

Question 19

• Desmopressin:
• MOA?
• Route?

Answer 19

• Selective for V2 on kidney

- Nasal

Question 20

• Vasopressin:
• MOA?
• Route? (3)

Answer 20

• V1 (Gq) and V2 (Gs = exocytosis of aquaporins)

- SC/IM/IV

Question 21

Adrenal Pharm:

• Effect of BK, Hist, Ach?
• Pheo treatment? (2) Ex?
• Ketone?
• Hydroxy at 11?
• Fludocortisone?
• Dethamexasone?
• 2 Cushing drop options?
• Primary aldo? (2)
• Androgen replacement?

Answer 21

• Vasodilate
• A block then B block; Phenoxybenzanine, Labatolol
• Inactive
• Active
• All mineral
• All gluco
• Ketoconazole, Carbergiline
• Spiranolactone, Eplenerone
• DHEA

Question 22

• Hydrocortisone MC:GC?
• Prednisone MC:GC?
• Methyprednisolone MC:GC?
• Triamcinalone MC:GC?
• Dexamethasone MC:GC?

Answer 22

• 1:1
• 4:1
• 5:0
• 5:0
• 30:0

Question 23

Calcium Pharm:

• Estrogen: 2 effects?
• Vit D - 4 effects?
• FGF23: 2 effects?
• Hypercalcemia treatment? (3)
• Hpocalcemia?

Answer 23

• Increase OB OPG; decrease clasts
• Increase PO4/Ca; Bone resorption, PO4 retention, lower PTH
• PO4 wasting; Less vit D activation
• Loop, IV, Bisphos.
• IV calcium

Question 24

• Cholecalcifirol:
• AKA?
• Preferred?

Answer 24

• D3

- Yes

Question 25

• Ergocalciferol:
• AKA?
• Preferred?

Answer 25

• D2

- No

Question 26

Calcifidiol?

• AKA?
• Used for?

Answer 26

• 25-D3

- Liver failure

Question 27

Calcitriol?

• AKA?
• Used for?

Answer 27

• 1,25 D3

- Renal patients

Question 28

Dihydrotachysterol?

• AKA?
• Requires?

Answer 28

• 1-D3

- 25 Hydroxy from liver

Question 29

Paracalcitol?

• MOA?
• Hypercalcemia?

Answer 29

• D3 receptors on gland not intestine

- No

Question 30

Alendronate?

• Drug type?
• MOA?
• Effective?
• SE? (2)

Answer 30

• Bispohosphanates
• Pyrophos. to block OC’s
• Yes
• Esophagitis/GI

Question 31

Estrogen?

• MOA? (2)
• Use?

Answer 31

• Increase OPG, lower OC’s

- Not much

Question 32

Raloxifine:

• Drug type?
• Act on? (4)
• Increased risk of?

Answer 32

• SERMS
• Bone, liver, uterus, breast
• Cancer

Question 33

Teriparatide:

• Drug type?
• MOA?

Answer 33

• PTH analog

- Increase OB formation

Question 34

Calcitonin-salmon:

• MOA?
• Effective?
• Route?

Answer 34

• Inhibits OC
• No
• Nasal

Question 35

Denosumab:

• Drug type?
• MOA?

Answer 35

• RANK-L Ab

- Lower OC activation

Question 36

HCTZ?

Flurosamide?

Answer 36

• Increase serum Ca

- Decrease serum CA

Question 37

• Tums/Calsup/Oscal:
• Absorption?
• SE? (2)

Answer 37

• Low

- Antacid, Rebound

Question 38

• Calcium Actetate:

- Use?

Answer 38

• IV infusion for low Ca

Question 39

• Calcium Gluconate:

- Use?

Answer 39

• IV infusion for low Ca

Question 40

• Calcium Chloride:

- Use?

Answer 40

• IV infusion for low Ca but vein irritating

Question 41

• Citracal:
• AKA?
• Recommended for?

Answer 41

Ca Citrate

- PPI users