Pharm Flashcards
1
Q
- Hypothryoid pregnant needs?
- Thyroid meds take how long to equilibrate?
- T4 –> T3 in periph blocked by? (3)
- Graves treatment? (3) Drugs? (5)
- Thyroid storm drugs? (4)
- Young with hyper? Old?
A
- T4 for fetus
- 6-8 weeks
- B-blockers, ipodate, corticosteroids
1. ) Interfere with prod: Thionamides, Iodides
2. ) Modify tissues: B Blockers/ Steroids
3. ) Destroy: RAI - Propranolol, NaI, PTU, Hydrocortisone
- Pharm; RAI
2
Q
Levothyroxine:
- AKA?
- Half life?
- Ther. Window?
A
- T4
- Long
- Narrow
3
Q
Liothyronine:
- AKA?
- Half life?
- Risk of? (2)
A
- T3
- Short
- Cardiac/osteoporosis
4
Q
Liotrix:
- AKA?
- SE?
A
- 4:1 T4:T3
- Osteoporosis
5
Q
USP:
- AKA?
- From where?
A
- Variable T3/T4
- Pig extract
6
Q
Methimaxole:
- Drug type?
- MOA? (2)
- High dose?
- SE? (4)
A
- Thionamides
- Block organo/ coupling
- Lowers periph conversion
- Pruritis, Arthralgias, Hepato, Agranulo
7
Q
PTU:
- Drug type?
- MOA? (2)
- High dose?
- SE? (4)
A
- Thionamides (Can use in pregnancy)
- Block organo/ coupling
- Lowers periph conversion
- Pruritis, Arthralgias, Hepato, Agranulo
8
Q
Iodides:
- MOA? (3)
- Risk?
- SE? (2)
A
- Decrease hormone release via high IC iodide, Inhibits TGB proteolysis
- Can make it worse
- Rash, rhinorrhea
9
Q
- GH Pharm:
- Gherlin leads to?
- GH increases? (2)
- Somatostatin/ IGF1?
- Nephrogenic DI can occur with? (3)
A
- Release of GH
- Insulin/ IGF-1
- Decrease GH
- Li, T2D, NSAIDS
10
Q
- Sermorelin:
- MOA?
- Effectiveness?
A
- Synthetic GHRH
- Not very
11
Q
- Somatropin:
- MOA?
- Route?
A
- Recomb. GH stim. IGF1
- IM
12
Q
- Somatrem:
- MOA?
- Route?
A
- Recomb. GH stim. IGF1
- IM
13
Q
- Mecaserem:
- MOA?
A
- GH resistant = IGF1 synthetic
14
Q
- Lanreotride:
- MOA?
- Decreases? (4)
- Route?
- Lasting?
A
- Somatostatin analog
- GH, Glucagon, Insulin, TSH
- Sub Q
- Long
15
Q
- Octeotride:
- MOA?
- Decreases? (4)
- Route?
- Lasting?
A
- Somatostatin analog
- GH, Glucagon, Insulin, TSH
- Sub Q
- Long
- Short
16
Q
- Bromocriptine:
- MOA?
- Decreases? (2)
A
- DA receptor agonist
- GH/ PRL
17
Q
- Cabergoline:
- MOA?
- Decreases? (2)
- Preferred?
A
- DA receptor agonist
- GH/ PRL
- Yes
18
Q
- Demecloclyine:
- MOA?
- Use?
A
- Blocks vasopressin
- SIADH
19
Q
- Desmopressin:
- MOA?
- Route?
A
- Selective for V2 on kidney
- Nasal
20
Q
- Vasopressin:
- MOA?
- Route? (3)
A
- V1 (Gq) and V2 (Gs = exocytosis of aquaporins)
- SC/IM/IV
21
Q
Adrenal Pharm:
- Effect of BK, Hist, Ach?
- Pheo treatment? (2) Ex?
- Ketone?
- Hydroxy at 11?
- Fludocortisone?
- Dethamexasone?
- 2 Cushing drop options?
- Primary aldo? (2)
- Androgen replacement?
A
- Vasodilate
- A block then B block; Phenoxybenzanine, Labatolol
- Inactive
- Active
- All mineral
- All gluco
- Ketoconazole, Carbergiline
- Spiranolactone, Eplenerone
- DHEA
22
Q
- Hydrocortisone MC:GC?
- Prednisone MC:GC?
- Methyprednisolone MC:GC?
- Triamcinalone MC:GC?
- Dexamethasone MC:GC?
A
- 1:1
- 4:1
- 5:0
- 5:0
- 30:0
23
Q
Calcium Pharm:
- Estrogen: 2 effects?
- Vit D - 4 effects?
- FGF23: 2 effects?
- Hypercalcemia treatment? (3)
- Hpocalcemia?
A
- Increase OB OPG; decrease clasts
- Increase PO4/Ca; Bone resorption, PO4 retention, lower PTH
- PO4 wasting; Less vit D activation
- Loop, IV, Bisphos.
- IV calcium
24
Q
- Cholecalcifirol:
- AKA?
- Preferred?
A
- D3
- Yes
25
- Ergocalciferol:
- AKA?
- Preferred?
- D2
| - No
26
Calcifidiol?
- AKA?
- Used for?
- 25-D3
| - Liver failure
27
Calcitriol?
- AKA?
- Used for?
- 1,25 D3
| - Renal patients
28
Dihydrotachysterol?
- AKA?
- Requires?
- 1-D3
| - 25 Hydroxy from liver
29
Paracalcitol?
- MOA?
- Hypercalcemia?
- D3 receptors on gland not intestine
| - No
30
Alendronate?
- Drug type?
- MOA?
- Effective?
- SE? (2)
- Bispohosphanates
- Pyrophos. to block OC's
- Yes
- Esophagitis/GI
31
Estrogen?
- MOA? (2)
- Use?
- Increase OPG, lower OC's
| - Not much
32
Raloxifine:
- Drug type?
- Act on? (4)
- Increased risk of?
- SERMS
- Bone, liver, uterus, breast
- Cancer
33
Teriparatide:
- Drug type?
- MOA?
- PTH analog
| - Increase OB formation
34
Calcitonin-salmon:
- MOA?
- Effective?
- Route?
- Inhibits OC
- No
- Nasal
35
Denosumab:
- Drug type?
- MOA?
- RANK-L Ab
| - Lower OC activation
36
HCTZ?
| Flurosamide?
- Increase serum Ca
| - Decrease serum CA
37
- Tums/Calsup/Oscal:
- Absorption?
- SE? (2)
- Low
| - Antacid, Rebound
38
- Calcium Actetate:
| - Use?
- IV infusion for low Ca
39
- Calcium Gluconate:
| - Use?
- IV infusion for low Ca
40
- Calcium Chloride:
| - Use?
- IV infusion for low Ca but vein irritating
41
- Citracal:
- AKA?
- Recommended for?
Ca Citrate
| - PPI users
