Pharm 2 COPY Flashcards
What is the MOA of nalbuphine?
Partial antagonist of the mu-opioid receptor
Partial agonist of kappa
Does nalbuphine have a ceiling effect?
Yes
Which anesthetic gas has the most significant global warming impact?
Desflurane
Which inhaled anesthetic gases may produce carbon monoxide?
Iso and Des
What receptor does midazolam work on?
GABA
When does serum potassium normalize after giving Suc to a healthy patient?
10-15 minutes
How much will potassium rise after giving succ in a health patient?
.5-1.0
Does chronic renal failure affect the rise in K after giving succ?
No
What disease do we need to be careful giving succ to?
Burns
Trauma
Myotonia
Muscular dystrophies
Significant denervation injuries
Prolonged immobilization
Spinal cord transections
Does benzocaine have a short or long duration of action?
Short. 10-60minutes
What is the concern if a patient is given high doses of benzocaine?
Methemoglobinemia
Is benzocaine ionized or unionized at physiologic pH? What does this mean?
unionized - will have a fast onset of action
Antidysrhythmic on action potentials
What are class 1A antiarrhythmics? What phase do they work on?
What are class 1B antiarrhythmics? What phase do they work on?
What are class 1C antiarrhythmics? What phase do they work on?
Potent sodium channel blockers
What are class 2 antiarrhythmics? What phase do they work on?
Beta blockers - they slow phase 4 depolarization in the SA node
What are class 3antiarrhythmics? What phase do they work on?
Potassium channel blockers - Phase 3 - decreases the magnitude of repolarization
What are class 4 antiarrhythmics? What phase do they work on?
Calcium channel blockers - prolong phase 2 - decrease conduction velocity
Cardiac myocyte action potential
What is the RMP of the cardiac myocyte? What about the threshold potential?
RMP; -90
TP; -70
Concentration response curve
Which local anesthetic is most likely to undergo ion trapping and cause issues to baby?
2.0% lidocaine
Which opioid has the lowest lipid solubility?
Morphine
