Pharm 2 Flashcards

1
Q

Lithium indications and MOA

A

Mood stabilizer, first line for bipolar, interferes with ion transport, notable tremor

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2
Q

Lithium contraindications

A

Severe CV / renal disease, dehydration, sodium depletion

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3
Q

Lithium drug interactions

A

oodles, may enhance risk of QT prolongers

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4
Q

Valproate indications and MOA

A

Anti-seizure, migraine prophylaxis, mania, enhances GABA

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5
Q

Valproate side effects

A

headache, nausea, vomiting, tremor

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6
Q

Valproate contraindications

A

pregnancy or childbearing potential

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7
Q

Risperidone indications and MOA

A

antipsychotic, treatment of irritability/aggression with autism, blocks dopamine and serotonin receptors

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8
Q

Risperidone side effects

A

urinary retention, weight gain, seizure, sedation, extrapyramidals, postural hypotension, sexual dysfunction, arrhythmia, xerostomia

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9
Q

Imipramine indications

A

enuresis in children over 6, depression

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10
Q

Imipramine MOA

A

tricyclic antidepressant, inhibits dopamine and serotonin reuptake, also block serotonergic, alpha adrenergic, histaminic, and muscarinic receptors

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11
Q

Imipramine side effects

A

weight gain, xerostomia, constipation, urinary retention, blurry vision, tachycardia, arrhythmia, nausea, drowsiness

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12
Q

Imipramine contraindications

A

recent MI, MAOi’s within 14 days, linezolid, methylene blue

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13
Q

Desipramime indications and MOA

A

Tricyclic antidepressant, SNRI

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14
Q

List anticonvulsants

A
LOVEPC
Lamotrigine
Oxcarbazepine
Valproate
Ethosuximide
Phenytoin
Carbamazapine
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15
Q

fluoxetine indications and MOA

A

antidepressant, SSRI

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16
Q

bupropion indications and MOA

A

antidepressant, NDRI, fewer sexual side effects than SSRI

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17
Q

venlafaxine indications and MOA

A

antidepressant, SNRI

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18
Q

SSRI side effects

A

nausea, anxiety, drowsiness, insomnia, sexual dysfunction, drug interactions

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19
Q

tricyclic side effects

A

weight gain, xerostomia, constipation, urinary retention, blurry vision, tachycardia, arrhythmias, nausea, drowsiness

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20
Q

common side effects of antiseizures

A

ataxia, n/v, sedation, rash, weight changes, teratogen, hyponatremia, osteoporosis

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21
Q

phenytoin indications and MOA

A

generalized and tonic clonic antiseizure, blocks sodium channels

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22
Q

lamotrigine indications and MOA

A

wide variety of seizures and bipolar disorder, sodium channel and high voltage calcium blocker

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23
Q

carbamazepine indications and MOA

A

focal, tonic-clonic, trigeminal neuralgia and bipolar disorder, sodium channel blocker

24
Q

oxcarbazepine indications and MOA

A

partial onset seizures, blocks sodium channels, modulates calcium channels

25
Q

valproate indications and MOA

A

focal and primary generalized epilepsies, blocks sodium channels, and GABA transaminase

26
Q

ethosuximide indications and MOA

A

only for absence seizures, inhibits T-type calcium channels

27
Q

chlorpromazine indications and MOA

A

antipsychotic, block D2 receptor, notable ataxia

28
Q

haloperidol indications and MOA

A

antipsychotic, block D2 receptor, notable ataxia

29
Q

2 first gen antipsychotics on this list

A

chlorpromazine and haloperidol

30
Q

3 second gen antipsychotics on this list

A

clozapine
risperidone
aripiprazole

31
Q

first gen antipsychotic big side effects

A

extrapyramidals

32
Q

second gen antipsychotic big side effects

A

diabeetus, hypercholesterolemia and weight gain

33
Q

clozapine indications and MOA

A

second generation antipsychotic, indicated only for the most refractory of mothafuckas

34
Q

bad effects of clozapine

A

bone marrow suppression, agranulocytosis, orthostasis, and seizures

35
Q

risperidone indications and MOA

A

second generation antipsychotic

36
Q

aripiprazole indications and MOA

A

second generation antipsychotic

37
Q

adverse effects of barbiturates

A

addictive, drowsiness, nausea, vertigo, tremors

38
Q

phenobarbital indications and MOA

A

sedation, GABA potentiation

39
Q

short acting benzo from list

A

diazepam

40
Q

medium acting benzo from list

A

alprazolam

41
Q

cyclobenzaprine indications and MOA

A

muscle relaxant, centrally acting

42
Q

alprazolam indications and MOA

A

intermediate acting benzo, potentiate GABA

43
Q

diazepam indications and MOA

A

short acting benzo, potentiate GABA

44
Q

benzo indications

A

anxiety reduction, sedative, hypnotic, anterograde amnesia, anticonvulsant, muscle relaxant

45
Q

buspirone indications and MOA

A

chronic GAD, not helpful for event specific anxiety due to long action, fewer CNS depression side effects, but has greater nausea. potentiates serotonin and dopamine

46
Q

zolpidem indications

A

hypnotic, no anticonvulsant or muscle relaxant properties. does not alter sleep stages like benzos

47
Q

ramelteon indications and MOA

A

sleeps, melatonin agonist

48
Q

baclofen indications

A

back-lofen, muscle relaxant acts on GABA receptors in spinal cord

49
Q

ergotamine indications

A

early onset migraine headaches

50
Q

ondansetron indications

A

antiemetic, especially during chemotherapy

51
Q

carbamazepines favorite seizure

A

complex partial

52
Q

first line for lots of seizures

A

phenytoin

53
Q

pro-drug converted by liver into morphine

A

codeine

54
Q

keep therapeutic levels of this for status epilep.

A

phenytoin

55
Q

benzos are class

A

IV