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NeuroBlock > Pharm 1 > Flashcards

Pharm 1 Flashcards

1
Q

Bethanechol indications

A

treatment of post-op and postpartum urinary retention (nonobstructive)

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2
Q

Bethanechol MOA

A

a synthetic ester of choline, stimulates parasympathetic nervous system, increases bladder muscle tone, also stimulates gastric motility

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3
Q

Bethanechol side effects

A

hypotension, tachycardia, colic, headache, diaphoresis, cramps, diarrhea, salivation, vomiting, urinary urgency, lacrimation, miosis, bronchoconstriction

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4
Q

Bethanechol contraindications

A

mechanical obstruction of GI or GU, hyperthyroidism, peptic ulcers, asthma, CAD, hypotension, parkinsonism

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5
Q

Bethanechol drug interactions

A

ACE inhibitors may enhance effect, Beta blockers may enhance effect

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6
Q

Pilocarpine indications

A

Systematic: xerostomia
Ophthalmic: Glaucoma management

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7
Q

Pilocarpine MOA

A

cholinergic agonist, stimulates miosis and lowering of intraocular pressure

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8
Q

Pilocarpine side effects

A

lacrimation, diarrhea, nausea, vomiting, decreased visual acuity

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9
Q

Pilocarpine contraindications

A

anterior chamber inflammation

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10
Q

Pilocarpine drug interactions

A

ACE inhibitors may enhance effect, Beta blockers may enhance effect

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11
Q

Atropine indications

A

Sinus bradycardia, inhibition of salivation and secretions, antidote for anticholinesterase poisoning, mydriasis

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12
Q

Atropine MOA

A

blocks acetylcholine at parasympathetic, muscarinic receptors

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13
Q

Atropine side effects

A

tachycardia, palpitations, ataxia, disorientation, anhidrosis, constipation, xerostomia, urinary retention, angle-closure glaucoma, blurry vision, mydriasis, increased intraocular pressure, fever

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14
Q

Atropine contraindications

A

Narrow-angle glaucoma, pyloric stenosis, prostatic hypertrophy

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15
Q

Atropine drug interactions

A

Anticholinergics may enhance effect, ACE inhibitors may decrease effect, may enhance constipation and urinary retention with opiates

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16
Q

Scopolamine indications

A

treatment of nausea and vomiting, decrease salivary and respiratory secretions, produce amnesia, sedation and tranquilization

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17
Q

Scopolamine MOA

A

block acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and CNS

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18
Q

Scopolamine side effects

A

orthostatic hypotension, tachycardia, restlessness and sedation (?), urinary retention, tremor, weakness, blurry vision

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19
Q

Scopolamine contraindications

A

glaucoma

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20
Q

Scopolamine drug interactions

A

Anticholinergics may enhance effect, ACE inhibitors may decrease effect, may enhance constipation and urinary retention with opiates

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21
Q

Ipratropium indications

A

bronchodilator

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22
Q

Ipratropium MOA

A

anticholinergic atropine derivative

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23
Q

Ipratropium side effects

A

bronchitis, sinusitis, xerostomia

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24
Q

Ipratropium contraindications

A

hypersensitivity

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25
Q

Ipratropium drug interactions

A

Anticholinergics may enhance effect, ACE inhibitors may decrease effect, may enhance constipation and urinary retention with opiates

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26
Q

Tubocurarine indications

A

skeletal muscle relaxation for operation

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27
Q

Tubocurarine MOA

A

nondepolarizing neuromuscular blocker, competitively block ACh

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28
Q

Tubocurarine side effects

A

hypotension

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29
Q

Tubocurarine contraindications

A

not commonly used, but one big contraindication is myocardial ischemia

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30
Q

Tubocurarine drug interactions

A

tetraethylammonium reverses effects

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31
Q

Succinylcholine indications

A

rapid sequence inductions, skeletal muscle relaxation for surgery

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32
Q

Succinylcholine MOA

A

the only depolarizing muscle relaxant in use today, activating nicotinic receptors to depolarize the neuromuscular junction

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33
Q

Succinylcholine side effects

A

arrhythmias, bradycardia, hyperkalemia, excessive salivation, increased intraocular pressure

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34
Q

Succinylcholine contraindications

A

malignant hyperthermia, acute phase of injury following multiple trauma or major burns, upper motor neuron lesion

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35
Q

Succinylcholine drug interactions

A

ACE inhibitors may increase serum concentration of succinylcholine, succinylcholine may enhance the bradycardic effect of opioids

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36
Q

botulinum toxin indications

A

induce local muscle paralysis, multiple applications

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37
Q

botulinum toxin MOA

A

blocks release of acetylcholine from synaptic vesicles

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38
Q

botulinum toxin side effects

A

pain, infection

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39
Q

botulinum toxin contraindications

A

infection at injection site, hypersensitivity

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40
Q

botulinum toxin drug interactions

A

aminoglycosides, neuromuscular blocking agents, anticholinergics all enhance effect

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41
Q

pyridostigmine indications

A

myasthenia gravis treatment, antagonism of nondepolarizing neuromuscular blockers, pretreatment for soman nerve gas exposure

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42
Q

pyridostigmine MOA

A

inhibition of acetylcholinesterase

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43
Q

pyridostigmine side effects

A

arrhythmias, convulsions, dizziness, diarrhea, nausea, salivation, vomiting, urinary urgency, lacrimation

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44
Q

pyridostigmine contraindications

A

asthma, bronchospasm, cholinergic sensitivity

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45
Q

pyridostigmine drug interactions

A

anticholinergic agents: diminished effect, beta blockers: enhanced, cholinergics: increased effect, succinylcholine: increased serum concentrations, nondepolarizing neuromuscular blockers: diminished effect

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46
Q

neostigmine indications

A

symptomatic control of myasthenia gravis, prevention of perioperative urinary retention, reversal of nondepolarizing neuromuscular blockers

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47
Q

neostigmine MOA

A

inhibition of acetylcholinesterase

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48
Q

neostigmine side effects

A

arrhythmias, convulsions, dizziness, diarrhea, nausea, salivation, vomiting, urinary urgency, lacrimation

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49
Q

neostigmine contraindications

A

peritonitis, urinary obstruction

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50
Q

neostigmine drug interactions

A

anticholinergic agents: diminished effect, beta blockers: enhanced, cholinergics: increased effect, succinylcholine: increased serum concentrations, nondepolarizing neuromuscular blockers: diminished effect

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51
Q

edrophonium indications

A

diagnosis of myasthenia gravis

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52
Q

edrophonium MOA

A

inhibition of acetylcholinesterase

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53
Q

edrophonium side effects

A

arrhythmias, convulsions, dizziness, diarrhea, nausea, salivation, vomiting, urinary urgency, lacrimation

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54
Q

edrophonium contraindications

A

hypersensitivity, GI or GU obstruction

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55
Q

edrophonium drug interactions

A

anticholinergic agents: diminished effect, beta blockers: enhanced, cholinergics: increased effect, succinylcholine: increased serum concentrations, nondepolarizing neuromuscular blockers: diminished effect

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56
Q

physostigmine indications

A

reversal of central nervous system anticholinergic syndrome

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57
Q

physostigmine MOA

A

inhibition of acetylcholinesterase, able to cross blood-brain barrier

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58
Q

physostigmine side effects

A

hallucinations, nervousness, restlessness, seizure, SLUD

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59
Q

physostigmine contraindications

A

GI, GU obstruction, asthma, diabetes, CV disease

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60
Q

phystostigmine drug interactions

A

anticholinergic agents: diminished effect, beta blockers: enhanced, cholinergics: increased effect, succinylcholine: increased serum concentrations, nondepolarizing neuromuscular blockers: diminished effect

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61
Q

epinephrine indications

A

treatment of anaphylactic reactions, treatment of shock hypotension, code drug for arrhythmia

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62
Q

epinephrine MOA

A

stimulates alpha and beta 1,2 adrenergic receptors

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63
Q

epinephrine side effects

A

angina, tachycardia, anxiety, xerostomia, urinary retention, tremor, weakness, exacerbation of glaucoma, diaphoresis

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64
Q

epinephrine contraindications

A

none in life-threatening situation, nose, ears, fingers, and toes for local anesthesia

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65
Q

epinephrine drug interactions

A

multiple, the gist: enhanced effect with sympathomimetics,

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66
Q

norepinephrine indications

A

severe hypotension

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67
Q

norepinephrine MOA

A

stimulates alpha and beta 1 adrenergic receptors, increasing heart contractility and vasoconstricting

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68
Q

norepinephrine side effects

A

arrhythmia, peripheral ischemia, anxiety, dyspnea

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69
Q

norepinephrine contraindications

A

hypersensitivity, non-emergent hypotension from extravasation

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70
Q

norepinephrine drug interactions

A

alpha and beta blockers, many others

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71
Q

dopamine indications

A

treatment of shock which persists after adequate fluid volume replacement

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72
Q

dopamine MOA

A

stimulates dopaminergic receptors and beta 1 adrenergic receptors

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73
Q

dopamine side effects

A

angina, anxiety, piloerection, elevated glucose, vomiting, increased intraocular pressure, polyuria, dyspnea

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74
Q

dopamine contraindications

A

hypersensitivity to sulfites, V fib

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75
Q

dopamine drug interactions

A

multiple, similar to norepi and epi

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76
Q

isoproterenol indications

A

mild or transient episodes of heart block

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77
Q

isoproterenol MOA

A

beta 1, 2 agonist

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78
Q

isoproterenol side effects

A

angina, dizziness, nausea, vomiting, tremor, blurry vision, diaphoresis

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79
Q

isoproterenol contraindications

A

angina, arrhythmia, cardiac glycoside intoxication

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80
Q

isoproterenol drug interactions

A

enhances sympathomimetics

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81
Q

albuterol indications

A

treatment or prevention of bronchospasm

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82
Q

albuterol MOA

A

beta 2 agonist in respiratory system

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83
Q

albuterol side effects

A

tachycardia, excitement, xerostomia, URI

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84
Q

albuterol contraindications

A

hypersensitivity, pregnancy (injected)

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85
Q

albuterol drug interactions

A

beta blockers diminish, sympathomimetics enhance

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86
Q

phenylephrine indications

A

nasal congestion

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87
Q

phenylephrine MOA

A

selective alpha agonist

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88
Q

phenylephrine side effects

A

burning, nasal discharge, sneezing

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89
Q

phenylephrine contraindications

A

hypersensitivity, V tach

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90
Q

phenylephrine drug interactions

A

alpha blockers diminish, sympathomimetics enhance

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91
Q

amphetamine indications

A

a drug of abuse, but some amphetamines are used to treat ADHD, obesity, and narcolepsy

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92
Q

amphetamine MOA

A

stimulates release of norepinephrine, serotonin, dopamine, inhibits monoamine oxidase

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93
Q

amphetamine side effects

A

arrhythmias, palpitations, agitation, anxiety, hallucinations, paranoia, restlessness, seizures, cool/blue fingers, bruxism, diaphoresis, liver failure, xerostomia

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94
Q

amphetamine contraindications

A

history of drug abuse, glaucoma, cardiovascular disease, hypertension, hyperthyroidism, agitation

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95
Q

amphetamine drug interactions

A

oodles, MAO inhibitors enhance, opioids enhanced, cns depressants less effective

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96
Q

levodopa indications (other name in combo)

A

treatment of parkinson’s (sinemet as levodopa/carbidopa)

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97
Q

levodopa MOA

A

blood-brain barrier crossing dopamine precursor

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98
Q

levodopa side effects

A

anorexia, nausea, tachycardia, hypotension, psychiatric problems

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99
Q

levodopa contraindications

A

hypersensitivity, narrow-angle glaucoma

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100
Q

levodopa drug interactions

A

oodles, MAOi’s enhanced, antipsychotics diminished, hypotensives enhanced

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101
Q

carbidopa indications

A

administered with levodopa to diminish side effects

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102
Q

carbidopa MOA

A

inhibits dopamine decarboxylase, does not cross blood brain barrier

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103
Q

carbidopa side effects

A

similar to levodopa, though less intense/frequent

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104
Q

carbidopa contraindications

A

hypersensitivity

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105
Q

carbidopa drug interactions

A

increases serum concentration of droxidopa, MAOi’s enhanced

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106
Q

entacapone indications

A

adjunct to levodopa/carbidopa for those with wearing off symptoms

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107
Q

entacapone MOA

A

inhibits catechol-0-methyltransferase, which converts levodopa into methyldopa. Methyldopa competes with levodopa

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108
Q

entacapone side effects

A

nausea, dyskinesa, dizziness, drowsiness

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109
Q

entacapone contraindications

A

hypersensitivity

110
Q

entacapone drug interactions

A

oodles, CNS depressants enhance CNS depression

111
Q

pramipexole indications

A

treatment of signs and symptoms of idiopathic parkinsonism

112
Q

pramipexole MOA

A

dopamine receptor agonist

113
Q

pramipexole side effects

A

sedation, hallucinations, confusion, nausea, hypotension

114
Q

pramipexole contraindications

A

none listed

115
Q

pramipexole drug interactions

A

alcohol may enhance sedative effect, MAOi’s enhance orthostatic hypotension effects, other CNS depressants enhance CNS depression

116
Q

ropinirole indications

A

treatment of parkinson disease

117
Q

ropinirole MOA

A

dopamine receptor agonist

118
Q

ropinirole side effects

A

sedation, hallucinations, confusion, nausea, hypotension

119
Q

ropinirole contraindications

A

hypersensitivity

120
Q

ropinirole drug interactions

A

alcohol may enhance sedative effect, MAOi’s enhance orthostatic hypotension effects, other CNS depressants enhance CNS depression

121
Q

selegiline indications

A

adjunct to levodopa/carbidopa in parkinson’s with diminishing effect of l/c, transdermal for major depressive disorder

122
Q

selegiline MOA

A

selectively inhibits MAO type a (metabolizes dopamine), will inhibit MAO type b at high doses

123
Q

selegiline side effects

A

headache, insomnia, dizziness, nausea

124
Q

selegiline contraindications

A

hypersensitivity

125
Q

selegiline drug interactions

A

oodles, MAOi’s enhanced, tramadol lowers seizure threshold and enhances neuroexcitatory

126
Q

isoflurane indications

A

maintenance of general anesthesia

127
Q

isoflurane MOA

A

variety of molecular mechanisms, increase sensitivity of GABAa

128
Q

isoflurane side effects

A

arrhythmia, hypotension, mood changes, nausea, vomiting, BUN decreased, creatinine increased, respiratory depression, malignant hyperthermia

129
Q

isoflurane contraindications

A

hypersensitivity, predisposition to malignant hyperthermia

130
Q

isoflurane drug interactions

A

oodles, CNS depressants enhance

131
Q

nitrous oxide indications

A

sedation, analgesia, amnesia

132
Q

nitrous oxide MOA

A

may inhibit action potentials, may act on opiate receptors,

133
Q

nitrous oxide side effects

A

headache, dizziness, confusion

134
Q

nitrous oxide contraindications

A

hypersensitivity, presence of intraocular gas bubble, do not administer without oxygen

135
Q

nitrous oxide drug interactions

A

CNS depressants enhance effect

136
Q

thiopental indications

A

induction of anesthesia, very short acting

137
Q

thiopental MOA

A

blocking of excitatory glutamate receptors, enhancing GABAa receptors: decreased neuronal activity

138
Q

thiopental side effects

A

addictiveness, drowsiness, nausea, vertigo, tremors, enzyme induction

139
Q

thiopental contraindications

A

hypersensitivity, hepatic impairment, dyspnea, sedative addiction

140
Q

thiopental drug interactions

A

oodles and oodles, CNS depressants enhance, enzyme inducers

141
Q

midazolam indications

A

preoperative sedation

142
Q

midazolam MOA

A

GABAa enhancement

143
Q

midazolam side effects

A

drowsiness, confusion, ataxia

144
Q

midazolam contraindications

A

hypersensitivity, glaucoma

145
Q

midazolam drug interactions

A

CNS depressants enhance

146
Q

ketamine indications

A

induction and maintenance of general anesthesia

147
Q

ketamine MOA

A

blocks glutamate at NMDA receptors

148
Q

ketamine side effects

A

increased ICP, salivation, increased intraocular pressure, respiratory depression

149
Q

ketamine contraindications

A

hypersensitivity, conditions in which increased blood pressure would be hazardous

150
Q

ketamine drug interactions

A

oodles, CNS depressants enhance, watch for metabolism

151
Q

fentanyl indications

A

pain management, adjunct to anesthesia

152
Q

fentanyl MOA

A

binds with many receptors in CNS, increases pain threshold, alters pain perception, inhibits pain pathways

153
Q

fentanyl side effects

A

hypotension, dysphoria, sedation, constipation, urinary retention, nausea, potential for addiction, respiratory depression

154
Q

fentanyl contraindications

A

opioid naive, hypersensitivity

155
Q

fentanyl drug interactions

A

oodles, CNS depressants enhance, watch for metabolism

156
Q

propofol indications

A

induction of anesthesia

157
Q

propofol MOA

A

GABAa agonist, possibly NDMA glutaminergic antagonist

158
Q

propofol side effects

A

hypotension, movement, apnea

159
Q

propofol contraindications

A

hypersensitivity, including to eggs or soy

160
Q

propofol drug interactions

A

oodles, CNS depressants enhance

161
Q

procaine indications (duration)

A

local anesthesia, short acting

162
Q

procaine MOA

A

blocks sodium channels, inhibiting action potential

163
Q

procaine side effects

A

local irritation, arrhythmia if IV

164
Q

procaine contraindications

A

hypersensitivity

165
Q

procaine drug interactions

A

watch for Cyp3a4 and cyp1a2 metabolism

166
Q

lidocaine indications (duration)

A

local anesthesia, intermediate acting

167
Q

lidocaine MOA

A

blocks sodium channels, inhibiting action potential

168
Q

lidocaine side effects

A

local irritation, arrhythmia if IV

169
Q

lidocaine contraindications

A

hypersensitivity

170
Q

lidocaine drug interactions

A

watch for Cyp3a4 and cyp1a2 metabolism

171
Q

bupivicaine indications (duration)

A

local anesthesia, long acting

172
Q

bupivicaine MOA

A

blocks sodium channels, inhibiting action potential

173
Q

bupivicaine side effects

A

local irritation, arrhythmia if IV

174
Q

bupivicaine contraindications

A

hypersensitivity

175
Q

bupivicaine drug interactions

A

watch for Cyp3a4 and cyp1a2 metabolism

176
Q

acamprosate indications

A

maintenance of alcohol abstinence

177
Q

acamprosate MOA

A

mechanism not fully defined, structurally similar to GABA

178
Q

acamprosate side effects

A

chest pain, anxiety, depression, decreased libido, xerostomia, suicide attempt

179
Q

acamprosate contraindications

A

hypersensitivity, severe renal impairment

180
Q

acamprosate drug interactions

A

no known significant interactions

181
Q

ethanol indications

A

drug of abuse, ethylene glycol overdose antidote, methanol overdose antidote, topical anti-infective

182
Q

ethanol MOA

A

competitively inhibits alcohol dehydrogenase (which metabolizes ethylene glycol and methanol into toxic metabolites)

183
Q

ethanol side effects

A

hypotension, agitation, disorientation, vertigo, nausea, vomiting, intoxication

184
Q

ethanol contraindications

A

hypersensitivity, seizure disorder, diabetic coma

185
Q

ethanol drug interactions

A

oodles, enhances CNS depressants, watch for liver metabolized stuff

186
Q

methanol indications

A

drug of abuse

187
Q

methanol MOA

A

metabolized by alcohol dehydrogenase to formaldehyde, then metabolized by aldehyde dehydrogenase into formic acid: metabolic acidosis, toxic to optic disk and putamen

188
Q

methanol side effects

A

increased MCV, cardiovascular failure, blindness (snowstorm), acidosis, diarrhea, dyspnea, death

189
Q

methanol contraindications

A

uh. . . being human?

190
Q

methanol drug interactions

A

N/A, I guess?

191
Q

ethylene glycol indications

A

drug of abuse

192
Q

ethylene glycol MOA

A

metabolized by alcohol dehydrogenase to glycoaldehyde, then by aldehyde dehydrogenase into glycolic acid and others: metabolic acidosis, encephalopathy

193
Q

ethylene glycol side effects

A

heart failure, acidosis, nausea, vomiting, diplopia, respiratory distress, ataxia, CNS depression, disorientation, coma

194
Q

ethylene glycol contraindications

A

uh. . . being human?

195
Q

ethylene glycol drug interactions

A

N/A, I guess?

196
Q

naltrexone indications

A

treatment of alcohol dependance

197
Q

naltrexone MOA

A

competitive antagonist to opioid receptors

198
Q

naltrexone contraindications

A

opioid dependance, opioid withdrawal, opioid use

199
Q

naltrexone side effects

A

syncope, headache, nausea

200
Q

naltrexone drug interactions

A

diminish opioids, enhance opioid antagonists, go figure

201
Q

disulfiram indications

A

management of chronic alcoholism

202
Q

disulfiram MOA

A

interferes with aldehyde dehydrogenase

203
Q

disulfiram side effects

A

with alcohol: flushing, nausea, thirst, palpitations, chest pain, vertigo

without alcohol: drowsiness

204
Q

disulfiram contraindications

A

psychosis, myocardial disease

205
Q

disulfiram drug interactions

A

ethanol, may increase serum concentration of diazepam

206
Q

thiamine indications

A

treat deficiency, as in Wernicke’s encephalopathy and Korsakoff’s syndrome

207
Q

thiamine MOA

A

an essential coenzyme in carbohydrate metabolism

208
Q

thiamine side effects

A

hypersensitivity, restlessness, hemorrhage into GI tract

209
Q

thiamine contraindications

A

hypersensitivity

210
Q

thiamine drug interactions

A

none known

211
Q

chloral hydrate indications

A

not used in US, short term sedative and hypnotic

212
Q

chloral hydrate MOA

A

mechanism unknown, CNS depressant

213
Q

chloral hydrate side effects

A

arrhythmia, diarrhea, CNS depression, hallucinations, nightmares

214
Q

chloral hydrate contraindications

A

hepatic or renal impairment

215
Q

chloral hydrate drug interactions

A

CNS depressants enhance

216
Q

nicotine indications

A

drug of abuse, given to wean for addiction

217
Q

nicotine MOA

A

autonomic ganglia and CNS stimulant, acts on nicotinic receptors

218
Q

nicotine side effects

A

risk of addiction, headache, cough, irritation

219
Q

nicotine contraindications

A

arrhythmias, pregnancy, angina pectoris

220
Q

nicotine drug interactions

A

adenosine: tachycardic effect enhanced, cimetidine may increase serum concentration of nicotine

221
Q

cocaine indications

A

drug of abuse, topical anesthesia for mucous membranes

222
Q

cocaine MOA

A

for anesthesia: blocks ion channels in sensory nerves, inhibiting action potential

for abuse: blocks reuptake of monoamines (norepi, serotonin, dopamine)

223
Q

cocaine side effects

A

CNS stimulation, loss of smell, chronic use depletes dopamine

224
Q

cocaine contraindications

A

hypersensitivity, ophthalmologic anesthesia (causes sloughing of corneal epithelium)

225
Q

cocaine drug interactions

A

cyp3a4 substrates enhanced

226
Q

methamphetamine indications

A

drug of abuse, ADHD, obesity

227
Q

methamphetamine MOA

A

sympathomimetic, CNS stimulant

228
Q

methamphetamine side effects

A

vertigo, hypertension, insomnia, confusion, addictive potential, nausea, diarrhea

229
Q

methamphetamine contraindications

A

glaucoma, cardiovascular disease, hypertension, agitation, predilection for addiction

230
Q

methamphetamine drug interactions

A

MAO inhibitors enhance hypertensive effect, diminishes effect of sedatives, enhances stimulants

231
Q

MDMA indications

A

drug of abuse, AKA molly, Ecstasy

232
Q

MDMA MOA

A

amphetamine, sympathomimetic, CNS stimulant

233
Q

MDMA side effects

A

vertigo, hypertension, insomnia, confusion, addictive potential, hyperthermia, serotonin syndrome

234
Q

MDMA contraindications

A

no indication for use, drug of abuse

235
Q

MDMA drug interactions

A

MAO inhibitors enhance hypertensive effect, diminishes effect of sedatives, enhances stimulants

236
Q

cannabis indications

A

drug of abuse, appetite induction, antiemetic, minor pain control

237
Q

cannabis MOA

A

acts on cannabinoid receptors in CNS

238
Q

cannabis side effects

A

tachycardia, impaired memory, hallucinations, conjunctivitis, increased appetite, impaired coordination

239
Q

cannabis drug interactions

A

enhance CNS depressants, enhance tachycardia with sympathomimetics

240
Q

cannabis contraindications

A

Hx schizophrenia, hypersensitivity

241
Q

bupropion indications

A

depression, smoking cessation

242
Q

bupropion MOA

A

not fully understood, norepinephrine and dopamine reuptake inhibitor

243
Q

bupropion side effects

A

tachycardia, headache, xerostomia, weight loss, blurry vision

244
Q

bupropion contraindications

A

seizure disorder, anorexia

245
Q

bupropion drug interactions

A

MAO inhibitors, linezolid, methylene blue, oodles

246
Q

varenicline indications

A

smoking cessation aid

247
Q

varenicline MOA

A

partial nicotinic receptor agonist

248
Q

varenicline side effects

A

suicidal thoughts, vivid nightmares, mood changes, headache

249
Q

varenicline contraindications

A

hypersensitivity

250
Q

varenicline drug interactions

A

enhance toxic effect of alcohol, trimethoprim, quinolones increase serum concentration

251
Q

dantrolene indications

A

malignant hyperthermia, spacticity

252
Q

dantrolene MOA

A

interferes with release of calcium from sarcoplasmic reticulum in skeletal muscle

253
Q

dantrolene side effects

A

drowsiness, limb pain, nocturia, dysuria

254
Q

dantrolene contraindications

A

active hepatic disease for oral formulation

255
Q

dantrolene drug interactions

A

CNS depressants enhance, oodles

256
Q

phencyclidine indications (AKA)

A

PCP, drug of abuse

257
Q

phencyclidine MOA

A

reduced glutamate activity due to NDMA receptor antagonism

258
Q

phencyclidine side effects

A

behavioral abnormalities, hypertension, tachycardia

259
Q

phencyclidine contraindications

A

no indication for use

260
Q

phencyclidine drug interactions

A

treat with benzodiazepines

261
Q

memantine indications

A

treatment of Alzheimer dementia

262
Q

memantine MOA

A

blocks NMDA receptors, preventing toxic levels of Ca in cell

263
Q

memantine side effects

A

hypertension, dizziness, incontinence, diarrhea

264
Q

memantine contraindications

A

hypersensitivity

265
Q

memantine drug interactions

A

bupropion, trimethoprim may increase serum concentration

266
Q

donepezil indications

A

treatment of Alzheimer dementia

267
Q

donepezil MOA

A

inhibits centrally-active acetylcholinesterase

268
Q

donepezil side effects

A

insomnia, nausea, diarrhea

269
Q

donepezil contraindications

A

hypersensitivity

270
Q

donepezil drug interactions

A

anticholinergics diminished by ACE inhibitors, may enhance bradycardic effect of bradycardics

NeuroBlock (8 decks)

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