PHARM Flashcards
what level of calciium do you need to admit?
> 3.40 mmol/L
Do not investigate as they need immediate admission
ecg finding in hypercalcaemia
shortened QT on ECG
Hypertension
Drugs that cause hypercalcaemia
Thiazide diuretics (bendro)
Lithium (alters PTH feedback threshold)
Excess vit D / A
Calcium + Omeprazole/Vit D -> milk-alkali syndrome
Do not give which abx with statins
macrolides: they are CyP450 inhibitors and increase conc of statins
Causes myopathy / rhabdo
when do you check LFTs after starting a statin
<3 months and at 12 months
do not prescribe a statin to
pregnancy
breastfeeding
active liver disease
ALT / AST >3x upper limit of normal
porphyria
HIV protease inhibitors
When do you review dose of metformin int he contect of renal failure?
if eGFR is less than 45 mL/min
When should you stop treatment with metformin
if eGFR is less than 30 mL/min
what are key side effects of metformin
vitamin b12 deficiency
diarrhoea
lactic acidosis
taste disturbance
Side effects of PDE-5 inhibitors
non-arteritis anterior ischaemic optic neuropathy
priapism
sudden hearing loss
myalgia
what are the contraindications of PDE-5 inhibitors
use with nitrates
uncontrolled hyper/hypotension
uncontrolled arrhythmias
stroke/MI within 6m
use with sildefanil
severe renal impairment
severe liver impairment
retinitis pigmentosa
after how long is IUS effective
7 days
triggers of roasea
emotional stress
caffeine, cheese, spicy foods
heat / sunlight / humidity
CCBs
topical corticosteroids
hirsutism management drug
facial: topical eflornithine
everywhere: dianette (co-cyprindiol)
causes of hirsutism
PCOS
idiopathic
congenital adrenal hyperplasia
androgen-secreting tumour
cushing’s syndrome
acromegaly
anabolic steroids
minoxidil
ciclosporin
phenytoin
