pharm Flashcards
Alpha 2-Adrenoreceptors
are G-protein coupled receptors involved in smooth muscle relaxation. Albuterol, a bronchodilator used in asthma, is one example of a β2-Adrenergic agonist. β2-Adrenergic agonists do not act on skeletal muscle, though tremors can be seen as a consequence of increased sympathetic tone.
Baclofen use for and MOA
γ-aminobutyric acid (GABA) analogue that acts as an agonist at GABA-B receptors. GABA-B receptors are metabotropic G-protein coupled receptors that increase efflux of potassium and thus hyperpolarize skeletal muscle cells and decrease action potential frequency. As such, baclofen is a first-line treatment for muscle spasticity. GABA-B receptors are also found in the central nervous system (CNS); therefore, baclofen can cause sedation, especially when used in conjunction with other CNS depressant
Calcium-sensing receptors
G-protein coupled receptors located in the renal tubule and parathyroid gland that sense the extracellular concentration of calcium ions. These receptors influence calcium homeostasis by regulating renal calcium reabsorption and parathyroid hormone release.
Ryanodine receptors
are calcium channels located on the sarcoplasmic reticulum membranes in skeletal muscle. These channels mediate the intracellular release of calcium during the excitation-contraction coupling essential to muscle contraction. Dantrolene antagonizes ryanodine receptors to treat muscle spasticity and malignant hyperthermia.
RANKL Osteoporosis; inhibits osteoclast
maturation (mimics
osteoprotegerin)
Denosumab
Abciximab
Platelet glycoproteins IIb/III
Infliximab
TNF alpha
TNF alpha receptor decoy
Etanercept
Trastuzumab
HER2
CD20 tx therapy name
Rituximab
Aldesleukin
Interleukin-2
Calcineurin inhibitor;
Cyclosporine
Nephrotoxicity immunosuppressants
Cyclosporine
Tacrolimus
FK506
Tacrolimus
Tacrolimus S/e
risk o diabetes
Azathioprine
6-mercaptopurine
