PH

Question 1

PH

Answer 1

Vasoconstriction of pulmonary vascular bed

Proliferation of endothelial and smooth muscle cells

Question 2

Regulation of Pulmonary Vascular Tone

Answer 2

Vasodilators: NO + Prostacycline
Vasoconstrictor: Endothelin

Question 3

PH Treatment (4)

Answer 3

1. Prostaglandins
   - Epoprostenol (Velitri) - IV
   - Treprostinil (Remodulin) - IV, SubQ, PO, Inhaled
   - Iloprost (inhaled)
2. Endothelin Antagonist
   - Bosenta (oral)
   - Ambrisentan (oral)
3. PDE5 Inhibitor
   - Sildenafil (IV, PO)
   - Tadalafil (PO)
4. NO (inhaled)