[PF] Classification of Diabetes Mellitus

Question 1

Immune-mediated

Answer 1

Type 1 diabetes (β-cell destruction, usually leading to absolute
insulin deficiency)

Question 2

Idiopathic

Answer 2

Type 1 diabetes (β-cell destruction, usually leading to absolute insulin deficiency)

Question 3

Type A insulin resistance

Answer 3

Genetic defects in insulin action

Question 4

Lipoatrophic diabetes

Answer 4

Genetic defects in insulin action

Question 5

Maturity-onset diabetes of the young (MODY), caused by mutations in:

Answer 5

Hepatocyte nuclear factor 4α (HNF4A), MODY1

Glucokinase (GCK), MODY2

Question 6

Pancreatic and duodenal homeobox 1 (PDX1), MODY4

Answer 6

Hepatocyte nuclear factor 1α (HNF1A), MODY3

Question 7

Hepatocyte nuclear factor 1β (HNF1B), MODY5

Answer 7

Hepatocyte nuclear factor 1α (HNF1A), MODY3

Question 8

Neurogenic differentiation factor 1 (NEUROD1), MODY6

Answer 8

Hepatocyte nuclear factor 1α (HNF1A), MODY3

Question 9

Neonatal diabetes

Answer 9

activating mutations in KCNJ11 and ABCC8, encoding

Kir6.2 and SUR1

Question 10

Maternally inherited diabetes and deafness (MIDD) due to

Answer 10

mitochondrial DNA

mutations

Question 11

Defects in proinsulin conversion

Answer 11

Genetic defects of β-cell function

Question 12

Insulin gene mutations

Answer 12

Genetic defects of β-cell function