Personalized Medicine Flashcards
1
Q
Pharmaogenetics is made up of _____ and ______
A
Pharmacokinetics and Pharmacodynamics
2
Q
What is pharmacokinetics?
A
Rate at which body absorbs/excretes/metabolizes drug
3
Q
What is pharmacodynamics?
A
How the body responds to the drug
4
Q
What is cytochrome P-450 important for?
A
Drug metabolism
5
Q
What happens if you are a poor metabolizer?
A
Buildup of toxic drug
6
Q
What happens if you are a fast metabolizer?
A
- Drug converted too quickly and accumulates (codeine into morphine)
- or no therapeutic effect
7
Q
Malignant hyperthermia
A
- autosomal dominant i
- reaction to drugs used during surgery/invasive procedures
- Sx: muscle rigidity, rhabdomyolysis, fever, acidosis, tachycardia
- mutation in RYR1
- Tx: muscle relaxants, cooling blankets, antiarrhythymics
8
Q
Adverse drug reactions: Steven-Johnson Syndrome (SJS)
A
- Causes widespread skin and mucous damage
- Sx: fever, unexplained widespread skin pain, rashes, blisters, shedding of skin
9
Q
Adverse drug reactions: toxic epidermal necrolysis
A
-more severe form of SJS
10
Q
Drugs that often cause SJS or TEN
A
- Antibacterial
- Anticonvulsants
- NSAIDS
