Emerging technologies Flashcards
1
Q
How do cells fix double strand breaks?
A
- homologous recombination
- non-homologous end joining
2
Q
Limitations of CRISPR
A
- no way to get CRISPR machinery from cell to cell
- immune response
- off target effects: “hitting other areas”
3
Q
Successful CRISPR clinical trials
A
- CTX001
- useful for thalassemia and sickle cell disease
- upregulate fetal hemoglobin by destroying repressor
4
Q
Intragenomic competition
A
B kills b
5
Q
True meiotic drivers
A
- Preferential segregation
- more gametes will have a specific allele
6
Q
Killer meiotic drivers
A
Destroy gametes that don’t contain specific allele
