Peripheral Nerves and Muscles pt. I Flashcards
What are the causes of peripheral nerve injury (5)
Nutritional, toxic, vascular, inflammatory, genetic
Charcot-Marie-Tooth nuropathies are in what etiologic category?
Inherited
What is Guillain-Barre Syndrome (BGS)?
Common, acute motor neuron demyelination
What kind of paralysis is associated with GBS?
ascending paralysis: “rubbery legs”, decreased DTR’s (deep tendon reflexes)
T/F
GBS is not lethal
False,
Possibly lethal from respiratory failure
What kind of condition is GBS?
Autoimmune: macrophages near nerve roots.
What causes GBS?
60% Idiopathic, viral: C.jejuni, EBV, CMV, HIV
Who is at most risk for GBS?
Males, ages 15-35 or 50-57 (biphasic distribution i.e. two specific age ranges implicated)
T/F
90% of GBS cases self resolve
True
What is the tx for GBS?
Ventilation, Plasmapheresis, I.V. antibodies
What is Chronic Inflammatory Demyelating Polyneuropathy (CIDP)?
Chronic version of GBS. Symmetricl, segmental demyelination/remyelination.
What cells are affected by CIDP?
Motor and sensory neurons, “onion-skin” Schwann cells.
What are some symptoms of CIDP?
Pain, paresthesia, ataxia, decrease DTRs
What kind of disorders is CIDP associated with?
Autoimmune disorders: lupus, HIV
What is the treatment for CIDP?
Plasmapheresis, immunosuppression,
What is the prognosis for CIDP patients?
Possible recovery, MC some residual
What is the #1 cause of perpheral neuropathy?
Diabetic peripheral neuropathy. 50% of Diabetes millitus cases.
What is diabetic peripheral neuropathy?
Axonal & demyelinating (mixed), symmetric
What happens with hyperglycemia relate to DPN?
Hyperglycemia = vascular injury -> nerve injury. Damaged vasa nervorum
What are some sensory abnormalities with DPN?
Decreased sensation: vibratory, soft touch, pain
What are some other signs of DPN?
Ulcers, gangrene, decreased (sluggish) DTRs
What is the tx for DPN?
Blood glucose, daily inspection. analgesics, anticonvulsants (because act on CNS to reduce pain).
How do environmental toxins cause misc. peripheral neuropathies?
Alter axonal transport of cytoskeletal damage (ADRs, lead, methyl-mercury). Longest neurons.
What does systemic vasculitis have to do with PN?
1/3 of vasculitis patients have peripheral neuropathy, polyarteritis nodosa (produces polyneuritis multiplex). Altered sentation (pain) and motor function.
What is a genetic misc PN?
Charcot Marie Tooth disease. PMP22 gene mutations. Axonal or demyelinating, motor and sensory
Who is most susceptible to Charcot Marie?
Young adults, slowly progressive (1:2,500)
What is a very notable condition associated with Charcot-Marie-Tooth disease?
Extreme pes cavus (foot)
What are neuromuscular jnx disorders?
Pres-synaptic Ca++ influx -> ACh -> post-synaptic ACh receptor -> myofiber depolarization (some sort of muscle contration, activity)
What is myasthenia gravis?
Autoimmune condition: acetylcholine receptor antibodies. Degradation of post synaptic ACh receptors
Rare: 3:100,000
What kind of lesions are noted with MG?
Thymic lesions: hyperplasia (60%), thymoma (20%) Autoreative T cells and B cells
What is the hallmark of MG?
Extraocular weakness: diplopia, ptosis
What age/gender is affected by MG
All Ages
Females (MC): Age: 20-30
Males: ages 50-70 years
T/F
MG symptoms get better as the day progresses and show relief with e-stimulation
False
MG symptoms get WORSE as the day progresses. E stim makes it worse.
What test is used for MG?
Tensilon test (edrophonium) Inhibits ACh receptor antibodies.
What is the tx for MG
Immunosuppression, cholisterase inhibitors, plasmapheresis, thymectomy.