Peripheral Nerve Injury

Question 1

Wallerian Degeneration

Answer 1

Transection of nerve that results in degeneration of axon and myelin sheath distal to site of axonal interuption

Question 2

In Wallerian Degeneration what happens to the endoneurium Sheath?

Answer 2

Sheath does not degenerate but forms tube direting regeneration

Question 3

Segmental Demyelination

Answer 3

Axons preserved (no wallerian degeneration)
Remyelination restores function

Question 4

Example of Segmental Demyelination

Answer 4

GBS

Question 5

Axonal Degeneration

Answer 5

Degeneration of axon cylinder and myelin

Progressing distal to proximal

Question 6

How does axonal degeration progress?

Answer 6

Distal to proximal

Question 7

Example of Axonal Degeneration?

Answer 7

Peripheral neuropathy

Question 8

Polyneuropathy

Answer 8

Bilatearl Symmetrical involvement of peripheral nerves

Question 9

Pattern of polyneuropathy

Answer 9

Distal earlier than proximal

Question 10

RAdiculopathy

Answer 10

Involvement of nerve roots

Question 11

3 levels of Traumatic Nerve Injury

Answer 11

Class 1: Neurapraxia
Class 2: Axonotmesis
Class 3: Neurotmesis

Question 12

Neurapraxia (Class 1)

Answer 12

Injury to nerve that causes transient loss of function

May be rapidly reversed or persist a few weeks

Question 13

Example of Class 1 Nerve Injury

Answer 13

Compression

Question 14

Example of Class 2 Nerve Injury

Answer 14

Crush Injury

Question 15

Axonotmesis (Class 2 Nerve Injury)

Answer 15

Injury to nerve interrupting the axon and causing loss of function and wallerian degeneration distal to the lesion

Question 16

Does axonototemesis (Class 2 Nerve Injury) affect endoneurium?

Answer 16

No

Question 17

Is regeneration possible with class 2 (axonotomesis) nerve injury?

Answer 17

Possible

Question 18

Neurotmesis (Class 3) is what?

Answer 18

Cutting of nerve with sevrance of all strutures and complete loss of function

Question 19

Reinervation of neurotemesis (Class 3)?

Answer 19

No