Peripheral blood smears

Question 1

Thalassemia

Answer 1

Profound hypochromic microcytic anemia

can see Tear drop cells, target cells and Heinz bodies

Question 2

Lead poisoning

Answer 2

basophilic stippling

Question 3

MAHA

Answer 3

schistocytes
MAHA is defined as nonimmune hemolysis (ie, negative direct antiglobulin test) with prominent red cell fragmentation (schistocytes) observed on the peripheral blood smear. Other clinical findings are: AKI, neurological abnormalities, fever(rare), reduced ADAMTS13 activity.

Question 4

AIHA

Answer 4

Spherocytes

Question 5

MDS

Answer 5

ringed sideroblasts, otherwise macro or normcytic. Immature cells such as elliptocytes, tear drops, acanthocytes
Basophilic stippling, Howell jolly bodies, megablastoid nucleated cells. Reticulocytosis may be indicative of superimposed AIHA.

Question 6

Smudge cells

Answer 6

Damaged lymphocytes seen typically in CLL