Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

perio > perio wound healing > Flashcards

perio wound healing Flashcards

1
Q

definition of WOUND

A

an injury to living tissue, a forcible interruption of the continuity of any tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

definition of WOUND HEALING

A

process involving cascade of cellular and molecular changes that occurred after tissue injury, resulting in either tissue repair or regen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

defn of FIRST INTENTION HEALING

A

primary union of a wound in which the incised tissue edges are held in close approximation until union occurS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

characteristics of healing by first intention

A

1) Wound completely close by approximating wound edges
2) Reduction of healing time by minimising the new tissue formation within wound
3) Reduction of bleeding and post op discomfort
4) Minimum scar formation and tissue loss
5) Suitable for regeneration/ grafting procedures, well repaired lacerations and clean wounds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

defn of healing by second intention

A

wound closure wherein the edges remain separated and the wound heals from the base and sides via formation of granulation tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

characteristics of healing by second intention

A

1) Wound is left open and allowed to close on its own
2) Slower healing, more discomfort and scar formation compared to healing by primary intention
3) Suitable mode as wound is kept open for drainage from infection or debri remeoval
4) Seen in extractions and ordinary flap operation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

defn of healing by third intention

A

delayed primary closure or tertiary wound healing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

characteristics of healing by third intention

A

1) Manage heavily infected or contaminated wounds
2) Primary closure is achieved when reduction of inflammation and bacterialcount is observed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

defn of REPAIR

A

healing of a wound by tissue that does not fully restore the architecture or function of the original part, includes reattachment and new attachment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

defn of REATTACHMENT

A

to attach again. The reunion of epithelial and CT with a root surface following separation by incision or physical injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

defn of NEW ATTACHMENT

A

union of CT or epithelium with a root surface that has been deprived of its original attachment apparatus. This new attachment may be epithelial adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

defn of REGENERATION

A

Reproduction of a lost part in a manner similar to its original form
In perio, its formation of new bone, cementum and functionally oriented PDL at a site derived of its original attachment apparatus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

in edentulous spaces, what does regeneration refer to

A

refers to surgical augmentation of a resorbed ridge
honestly wtf does this mean

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what happens after scrd?
- microbial biofilm disruption leads to ____, which halts the ____, resulting in improvement of clinical signs of the disease

A

reduction of host response cascade*, halting periodontal destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

in wound healing, cell to cell interactions are orchestrated by what?

A

growth factors, cytokines, ECM components

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which phase is the most important phase in wound healing? why?

A

hemostasis phase because the clot needs to form to protect what is left behind (otherwise will bleed to death), and is also the start so that granulation tissue can move to the site (cell migration)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what process starts immediately after initial injury and lasts 3-6 hours

A

blood clot formation
- a fibrin clot that comprises of activated platelets, neutrophils, RBCs embedded in a matrix of fibrin fills the site and initiates recruitment of inflammatory cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

functions of the blood clot

A
  • ensure that primary hemostasis is achieved
  • protects denuded (covering stripped) tissues at this first phase
  • serves a provisional scaffold for cell migration
  • degranulating platelets release pro inflammatory cytokines and growth factors that have inductive and conductive properties
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what are some examples of pro inflammatory cytokines and growth factors released by degranulating platelets

A

TGF-b, PDGF, FGF, EGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what does PDGF and TGF-b do?

A

induce chemotactic attraction of neutrophils and activate differentiation of monocytes into mature macrophages after infiltration of the injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what does EGF and VEGF do

A

enhance vascular permeability and chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what do keratinocytes do

A

produce IL1 that is involved in chemotaxis of neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what produces IL1 that is involved in chemotaxis of neutrophils

A

keratinocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what molecules enhance vascular permeability and chemotaxis

A

EGF and VEGF

25
what molecules activate differentiation of monocytes into mature macrophages after infiltration of the injury
PDGF and TGF-b
26
which day after injury does wound contraction form
day 3
27
which process starts within minutes of injury and lasts 4-6 days
inflammatory phase - starts concomitantly with hemostasis
28
what are the key cells of inflammatory phase
neutrophils and macrophages
29
what is the aim of inflammatory phase
to phagocytose and remove damaged tissue components, bacteria and foreign material
30
how do inflammatory cells migrate into the wound
via chemotaxis
31
after inflammatory cells migrate into the wound via chemotaxis, what happens after?
sequential infiltration of neutrophils, macrophages and lymphocytes
32
what cytokines promote recruitment and activation of T and B cells, and osteoclasts?
IL-1b, IL-6, TNF-a, TGF-b
33
what do IL-1b, IL-6, TNF-a, TGF-b do
promote recruitment and activation of T and B cells, and osteoclasts also initiates proliferation of keratinocytes and gingival fibroblasts
34
in specifics, what does TGF-b do?
- activates gingival fibroblasts to induce production of MMP2 and MMP9 - stimulates proliferation of osteoclast precursor - stimulates differentiation and promotion of bone resorption - promotes macrophage activation
35
what does collagenase do
degrades collagen and fibronectin in ECM
36
what happens in the late inflammatory phase
- lymphocytes infiltrate the wound and influence gingival fibroblast proliferation and collagen biosynthesis - reduction in inflammatory stimuli decreases the neutrophils and macrophages in the wound area and leads to switching of inflammatory macrophages to wound healing macrophages
37
in which phase does lymphocytes infiltrate the wound ?
late inflammatory phase
38
when do inflammatory macrophages switch to wound healing macrophages
late inflammatory phase
39
defintion of granulation tissue
is healing tissue that forms in response to any injury or surgical insult of soft tissue
40
what does granulation tissue consist of
fibroblasts, capillary buds, inflammatory cells, edema
41
what phase follows the inflammatory phase and lasts 4-14 days
granulation tissue formation/ proliferative phase
42
the proliferative phase is after which phase, and how long does it last
after inflammatory phase, lasts 4-14 days
43
the proliferative phase is characterised by formation of ____
granulation tissue
44
granulation tissue is _____ tissue rich in ____
highly vascularized, fibroblasts
45
what does IGF do
induces chemotactic attraction and activates proliferation of PDL
46
epithelial cells exhibiting the highest proliferative rate explains the development of
long junctional epithelium (apical migration of JE terminating at apical end of instrumentation)
47
a proportion of fibroblasts converts to ____ which will draw ______ together, result in decrease in size
myofibroblasts, wound edges
48
what is the remodelling phase characterised by
development of a new epithelium, elimination of grnulation tissue and ECM remodelling
49
in the proliferative phase, macrophages release PDGF and TGFb to stimulate what
gingival fibroblast proliferation and synthesis
50
in the proliferative phase, macrophages release what to stimulate gingival fibroblsat proliferation and synthesis?
PDGF and TGFb
51
gingival fibroblsats and PDL play an important role in the re organization of what
of ECM through the synthesis of different types of collagen
52
in the proliferative phase, PDGF and TGFb are also released during bone resorption leading to
stimulation of osteoblast migration during bone remod and differentiation
53
in the remodelling phase, what factor that is released from extracellular bone matrix induces the migration of bone MSCs for bone remod?
IGF
54
in the remod phase, IGF released from extracellular matrix induces what
induces migration of bone MSC for bone remod
55
in remod phase, BMP4 released from extracellular bone matrix induces what
induces osteoblast differentiation and increase recruitment of MSC
56
what are lipoxins
are metabolites of AA and are isolated from activated human leukocytes
57
what are resolvins
derived from omega 3 fatty acid chains
58
what is the role of lipoxins and resolvins
they block the pdtion of pro inflam mediators and promote the resolution of inflammation
59

perio (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions