Perio Flashcards
What are the development phases of the periodontal biofilm
conditioning film
linking film
congregation, reconditioning film
accumulation, shedding
What are the important microorganisms at health
oral streptococci
actiomyces
veillonella
fusobacterium
What are the important organisms in gingivitis
actinomyces
p. intermedia
bacteroides
fusobacterium nucleate
What are the important organisms in periodontitis
p. gingival
tannerala forsythia
treponema denticola
p. intermedia
What are the two microbial interactions
competition
cooperation
What is competition
metabolic products - acids, oxidants
bacteriocins
receptor antagonism
What is cooperation
metabolic products
adhesion substrates
immune avoidance
Why is Koch’s postulate difficult to prove
culture
present in disease
actively identifying disease
animal models
What is the alternative criteria for Koch’s Postulate
Association which disease based on increased numbers of pathogen at site of disease
Elimination or decreased numbers results in return to health
evidence of host response to pathogen based on humoral and cellular immunity
pathogenic potential based on animal models
possession of pathogen whith demonstrable virulence factors that cause periodontal destruction
What is p. gingival
keystone oral pathogen
increased numbers in PD
suppressed or undetectable in successfully treated lesions
increased serum fo GCF in PD
What are the virulence factors of p. gingival
host cell tissue adherence and invasion via fimbriae
elaboration of proteases that are degradative enzymes
LPS endotoxin
capsular polysaccharide and outer membrane vesicles
tissue toxic metabolic by-products - hydrogen sulfide, ammonia, fatty acids
What are the function of fimnraller adhesions
help invade membrane vesicle of host cells by binding to cellular integrins
What are the types of fimbrae
long and short
What are long fimbrae
long and peritrichous
initial attachment and biofilm organization
What is short fimrbae
cell to cell autoaggregation
micro colony formation
