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Perio > Perio > Flashcards

Perio Flashcards

1
Q

What percent is IgG?

A

80-85% (21 days)

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2
Q

What percent is IgM?

A

5-10 (10 days)

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3
Q

What percent is IgA?

A

10 % (6 days)

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4
Q

What antibody is secretory?

A

IgA

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5
Q

What antibody is the antigen receptor on B lymphocytes?

A

IgD

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6
Q

What antibody is involved with mast cells, basophils, histamine, allergic responses?

A

IgE

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7
Q

What’s the variable region called?

A

Fab

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8
Q

Whats the fixed region called?

A

Fc

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9
Q

What’s a local response?

A

residence cells stay in the connective tissue

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10
Q

Difference in monoclonal and polyclonal response?

A

Monoclonal: just one antibody made, it’s easy to find
Polyclonal: so many antibodies are produced that you can’t find it (needle in haystack analogy)

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11
Q

What’s systemic exposure?

A

When the bacteria breaks the epithelium

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12
Q

What are the two parts of gingivitis and limited disease?

A

Neutrophil clearance

Bacterial penetration

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13
Q

What’s an LBP? and where is it?

A

LPS binding protein (on a macrophage)

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14
Q

What cell helps with building and turning over collagen?

A

Fibroblast

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15
Q

What’s an endo vs exo peptidase?

A

Endopeptidase: cleaves inside the molecule
Exopeptidase: cleaves outside the molecule

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16
Q

What’s the main part of bone?

A

collagen

17
Q

What does IL-1 do?

A

stimulates osteoclasts, osteoblasts, fibroblasts etc.

18
Q

What happens to people that produce lots of IL-1?

A

more sights of bleeding

19
Q

What two groups have more susceptibility to monocyte dysregulation/

A

diabetics

smokers

20
Q

What is monocyte dysregulation?

A

Increased inflammation
INcreased MMP expression
Increase tissue destruction

21
Q

What class is CD4 going to bind to?

A

MHC class 2

22
Q

What class is CD8 going to bind to?

A

MHC class 1

23
Q

What is CD4 and CD8?

A

coupled receptors with the TCR

24
Q

What interleukin plays a role in bone resorption?

A

IL-6

25
Q

What does TNF-a do?

A

increases PMN adherence to endothelial cells

26
Q

What are 5 characteristics of “established gingivitis”??

A

1 Microbial plaque that is better organized and more gram-neg enters sulcus
2 Small gingival pocket epithelium forms
3 More venules become activated, enhanced expression IL-8, ICAM-1, E-selectin, PMN migration
4. Enlarging infiltrate with B and T cells, plasma cells, macrophages
5. PMN’s are prominent

27
Q

What are the 5 Proinflammatory/destructive events? (hallmark of perio disease)

A 
IL-1b
TNF-a
IFN-y
PGE
MMP's
28
Q

What are the 5 anti-inflammatory events?

A 
TGF-b
IL-1ra
IL-10
IL-4
TIMP (tissue inhibitors of matrix metalloproteinases)
29
Q

Are macrophages long lived?

A

Yes

30
Q

Do PMN’s act as APC’s?

A

No

Perio (3 decks)

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