Perio 2

Question 1

What is the primary proteinase family in perio tissue damage?

Answer 1

MMP (17 different ones)

Question 2

What inhibits MMP’s?

Answer 2

tetracycline

low dose doxycycline

Question 3

What happens with high levels of PGE2?

Answer 3

gingival inflammation

bone resorption

Question 4

What do PGE2, IL-1 and TNF-a do?

Answer 4

Together they cause perio disease

Question 5

What can be used as a screening to predict future attachment loss?

Answer 5

PGE2 levels in the GCF

Question 6

What drugs block PGE2 synthase?

Answer 6

NSAIDS (ibuprofen, tylenol)

Question 7

What levels are high in high risk patients?
>refractory
>early onset
>diabetic

Answer 7

PGE2

Question 8

What are the two models of hyperresponsiveness?

Answer 8

1. chronic infection and LPS exposure might lead to systemic elevations of TNF-a IL-1b and CSF which are all capable of up-regulating monocyte PGE2 secretion
2. Alternatively there is extensive data which establish a genetic basis in the region of chromosome 5 in the area of the TNFb genes

Question 9

??????How are leukotrienes and pge2 connected?????

Answer 9

???

Question 10

What outside forces can influence perio disease?

Answer 10

Stress

Question 11

What does CRF (corticotropin releasing factor) do?

Answer 11

in stress it increases, and it upregulates IL-1, TNFa and inflammation