peptic ulcer disease Flashcards
Controls the rate-limiting step in prostaglandin synthesis (cyclooxygenase pathway)
Phospholipase A2
Blocks cyclooxygenase pathway (patient may bleed due to anti-platelet activity, TXA2)
NSAIDs & Aspirin administration
describe what is an ulcer
local defect or excavation of the surface of an organ •or tissue that is produced by the sloughing shedding of inflamed necrotic tissue
in cases of emergency perforations in ulcer, what should you do
omental patching
Gastric ulcer i predominantly located where
along the lesser curvature near the interface of the body and antrum
Usually occur within a few centimeters of the pyloric •valve and involves the anterior wall
duodenal ulcer
ulceration usually occurs where
mucosal level
Associated with H. pylori induced hyperchlorhydric •chronic gastritis
PUD
PUD is most commoin in (2)
gastric antrum and 1st portion of duodenum
what can cause PUD
imbalances of mucosal defenses and damaging forces
3 forms of H pylori infection
Coccoid
Tubular
Flagellated
how does duodenal ulcer develop from increased gastric acid production by infection
Coccoid
Tubular
Flagellated
use of cocaine and meth results to deep ulcers and perforations due to
mucosal ischemia
Zollinger-Ellison Syndrome is caused by gastrin-secreting GUT neuroendocrine tumors (gastronomas) arising most commonly in the
Duodenal wall:
also in Pancreas (25%)
Duodenal wall (45%)
Lymph nodes (5-15%)
char of classic ulcer lesion
Lesions less than 0.3 cm in diameter tend to be shallow; Sharply punched out defect
