Peptic Ulcer Disease

Question 1

Pertinent Anatomy for peptic ulcer disease

Answer 1

(1) Stomach
(2) Duodenum

Question 2

Peptic ulcer Pertinent Physiology
Aggressive factors, such as _________ drugs , ______ infection, bile salts, acid, and pepsin, can alter the mucosal defense by allowing back diffusion of hydrogen ions and subsequent epithelial cell injury.

Answer 2

nonsteroidal anti- inflammatory drugs
H pylori infection

Question 3

What percent of patients present with ulcer complications without antecedent symptoms?

Answer 3

10 to 20 percent

Question 4

True/False
Most NSAID-induced ulcers are very symptomatic

Answer 4

False
asymptomatic.

Question 5

Peptic ulcer
What is the diagnostic procedure of choice in most patients?

Answer 5

Upper endoscopy with gastric biopsy for H pylori

Question 6

Although ulcers can occur in any age group,
1) ____ ulcers most commonly occur in patients between the ages of 30 and 55 years,
2) _____ ulcers are more common in patients between the ages of 55 and 70 years.

Answer 6

1) duodenal
2) gastric

Question 7

What are three major causes of peptic ulcer disease:

Answer 7

(a) NSAIDs
(b) Chronic H pylori infection
(c) Acid hypersecretory states

Question 8

What is the hallmark of peptic ulcer disease, is present in 80-90% of
patients.

Answer 8

Epigastric pain (dyspepsia),

Question 9

What is an anti-H pylori regimen

Answer 9

10-14 days
Proton pump inhibitor orally twice daily,
Clarithromycin 500 mg orally twice daily,
Amoxicillin 1 g orally twice daily

Question 10

Disposition
May stay on the ship unless any red flags or …….

Answer 10

not responsive to Proton pump inhibitor therapy