Peptic Ulcer Disease

Question 1

What is PUD?

Answer 1

a group of gastrointestinal disorder ,the variety based on the degree of gut.

Question 2

What is the cause of PUD?

Answer 2

They are caused by imbalance between aggressive and defensive factors.

Question 3

What are the aggressive factors of PUD?

Answer 3

H.Pylor, NSAIDS , gastric acid , Pepsin and smoking

Question 4

What are the defensive factors of PUD?

Answer 4

Mucus , Bicarbonate , Blow flow and Prostaglandines

Question 5

What are the most common cause of PUD?

Answer 5

Helicabater pylori (H,pylori) and NSAIDS.

Question 6

What are the treatment of H Pylori associated ulcers?

Answer 6

Antibiotics (minimum of 2 different agent ) and Antisecretory agent ( PPI or H2RA fasten healing and retrieve symptoms up to 14 days)

Question 7

What are the antibiotics for H.Pylori?

Answer 7

Clarithromycin , Amoxicillin , Bismuth , Tetracycline , Metronizade , Trinidazole.

Question 8

METRONIZADE AND TINIDAZOLE

Answer 8

MECHANISM OF ACTION : Inhibits bacteria cellular metabolic process.
ADVERSE EFFECTS : Nausea and vomiting
OOTHER CONSIDERATION : Avoid in pregnancy and alcohol

Question 9

CLARITHROMYCIN

Answer 9

MECHANISM OF ACTION : Inhibits bacterial protein synthesis
ADVERSE EFFECT : Nausea , Diarrhea , change in taste
OTHER CONSIDERATION : N/A

Question 10

AMOXICILLIN

Answer 10

MECHANISM OF ACTION : inhibits bacterial cell walL synthesis.
ADVERSE EFFECT : diarrhea
OTHER CONSIDERATION : Low resistance rate , work better at higher PH

Question 11

BISMUTH

Answer 11

MECHANISM OF ACTION : Disrupt bacterial cell wall
ADVERSE EFFECT : Black discoloration of tongue and stool.
OTHER CONSIDERATION : N/A

Question 12

TETRACYCLINE

Answer 12

MECHANISM OF ACTION : inhibits bacterial protein synthesis
ADVERSE EFFECTS : stain developing on teeth and skin
OTHER CONSIDERATION : Do not use in pregnant and young children.