HEADACHES AND GOUT

Question 1

CYCLOOXYGENASE (COX) INHIBITORS

Answer 1

Aspirin (ASA) ,NSAIDS,Acetaminophen (APAP).
THERAPEUTIC EFFECTS: suppress inflammation, relieve pain, reduce fever
Aspiring can also protect against MI and stroke.

Question 2

COX1 (good)

Answer 2

MECHANISM OF ACTION : beneficial process, GI track decrease gastric acid, increase bicarbonate and mucus.Platelet aggregation and kidney vasodilation.

Question 3

COX2 (bad)

Answer 3

MECHANISM OF ACTION : Tissue injury (inflammation and pain). Brain fever and pain. Kidney vasodilation.

Question 4

FIRST GENERATION NSAIDs

Answer 4

Use to treat inflammation disorders.

MECHANISM OF ACTION: Inhibits COX-1 and 2. It has an increased risk factors.

Question 5

ASPIRIN

Answer 5

MECHANISM OF ACTION: Irreversible non-selective inhibitor of COX-1 and 2.
PHARMACOKINETICS: Absorption is rapid and complete with oral dosing but slower with rectal . Distribution is highly protein bound it a has a short half-life and it is excreted really , highly dependent on urine PH.

Question 6

ASPIRIN ADVERSE EFFECTS

Answer 6

Gastrointestinal , bleeding , renal impairment , Reye’s syndrome , hypersensitivity , salicylism , and it must be avoid in pregnancy.

Question 7

ASPIRIN DDI

Answer 7

Anticoagulants, Glucocorticoids , alcohol , NSAIDs , Angiotensin converting enzyme inhibitor, Angiotensin II receptor blockers.

Question 8

ASPIRIN OVERDOSE

SIGNS AND SYMPTOMS OF OD AND TREATMENT OF OD

Answer 8

Lethal dose in adults is 20-25 grams and -4 grams in children.
SIGNS AND SYMPTOMS OF OD: Respiratory alkalosis (hyperventilation), electrolytes imbalances , coma, hyperthermia and sweating
TREATMENT : Supportive care , external cooling, sodium bicarbonate infusion