PEP

Question 1

What drugs? How long? Don’t mix with?

Answer 1

Tenofovir disoproxil 245mg Emtricitabine 200mg

Raletegravir 1200mg

Once daily 28 days

Don’t take with antacids, fe, vitamins

Question 2

When start?

Answer 2

ASAP ideally <24 hr
Do not give > 72 hr

Question 3

What baseline tests?

Answer 3

All:
HIV
Hep B unless immunised
creatinine and eGFR
ALT

If sexual exposure sexual health screen including hepatitis C if MSM etc

All occupational exposure hepatitis C screen

Pregnancy test

Question 4

What follow up?

Answer 4

Window periods for SHS
45 day post completion HIV test can align with STS and make it 12/52 if sexual risk

Question 5

If giving PEP what else do you consider?

Answer 5

EC
Hepatitis B vaccine for all if not immune
Would PreP be relevant?
Encourage adherence
Leaflet

Question 6

Do you ever not give PEP if hiv positive?

Answer 6

Yes if undetectable on ART > 6/12

Question 7

When do you always give PEP if don’t know hiv status?

Answer 7

Receptive anal sex

(Consider insertive)