people Flashcards

1
Q

Meselson and Stahl

A

confirmed semi-conservative model

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2
Q

John Cairns

A

replication begins from origin (OriC) bidirectionally

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3
Q

Lehman

A

discovered DNA ligase function

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4
Q

Mueller

A

telomere structure

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5
Q

Blackbur and Szotak

A

yeast telomer structure

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6
Q

Greider

A

identified TERT (telomerase reverse transcriptase) and TR (telomerase RNA)

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7
Q

LAng and Griffith

A

T-loop:single stranded DNA at chromosome ends

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8
Q

Collins

A

Human genome project/telomers linked to aging

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9
Q

WAtson and Crick

A

standard beta-form double helix

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10
Q

Miller and Hamkalo

A

transcription and termination in prokarytoes are coupled

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11
Q

SHatkin

A

discovered capping of nascent pre-mRNAs using virus (reovirus)

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12
Q

SHarp and Roberts

A

discovered RNA splicing

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13
Q

Tilghman

A

discovered R-loop

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14
Q

Cech

A

autocatalytic splicing of RNA precursor

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15
Q

LEderberg

A

mutation is non-adaptive

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16
Q

Beadle and Tatum

A

one gene one enzyme hypothesis

17
Q

Yanofsky

A

co-linearity b/w a gene and its protein in prokaryotes

18
Q

Ramkrishana, Steitz and Yonath

A

structure and function of ribosome

19
Q

Crick

A

wobble hypothesis

20
Q

McClintock

A

purposed the concept of “jumping genes”

21
Q

Monod and JAcob

A

identified repressor (I) gene a promoter (P) a regualtory element operator(O) and 3 structural genes (lacZ, lacY and lacA)