Pentose Phosphate Pathway: Irreversible (Redox) Pathway

Question 1

Where does the Pentose phosphate pathway (irreversible) occur?

Answer 1

Liver and RBC

Question 2

In the PPP the purpose is to generate NADPH for antioxidant Protection for function of the enzyme glutathione reductase in the _______ and _______

Answer 2

Liver and RBC

Question 3

When the PPP redox (pentose phosphate pathway) goes to the _________, it’s purpose is to generate NADPH for fatty acids synthesis and cholesterol synthesis

Answer 3

Liver ONLY

Question 4

During the PPP, Where can cholesterol can then be converted to steroid hormones, vitamin D and bile acids/salts.

Answer 4

Liver ONLY

Question 5

What is step 1 for the redox PPP

Answer 5

Glucose 6P + NADP+ –> 6P gluconate + NADPH

Question 6

What is the enzyme is used for step 1in the redox PPP

Answer 6

Glucose 6P Dehydrogenase

Glucose 6P + NADP+ –> 6P gluconate + NADPH

Question 7

What is the enzyme used for step 2 in the redox PPP

Answer 7

6P Gluconate Dehydrogenase

Question 8

What is step 2 for the redox PPP

Answer 8

6P gluconate + NADP+ ——-> Ribulose 5P + CO2 + NADPH