Pentose Phosphate Pathway and Glycogen

Question 1

Uses of NADPH

Answer 1

• Synthesis of fatty acids and cholesterol
• fixation of ammonia by glutamate dehydrogenase
• oxidative metabolism of drugs and poisons by cytochrome P450 enzymes
• generation of nitric oxide and of reactive oxygen species by phagocytes
• scavenging of reactive oxygen species that form as by-products of oxygen transport and of the respiratory chain