Pentose Phosphate Pathway Flashcards

1
Q

Which other metabolic process does the PPP mirror?

A

The Calvin Cycle

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2
Q

What are the two key Phases of the PPP?

A

Phase 1 = oxidative generation of NADPH
Phase 2 = non-oxidative (reversible)

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3
Q

Which organisms does the PPP take place?

A

ALL!

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4
Q

Where does the PPP take place?

A

Cytoplasm

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5
Q

What is the starting molecule in the PPP?

A

Glucose-6-Phosphate G6P

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6
Q

(Simply) Why are there different fates of G6P?

A

Dependent on cell’s requirements

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7
Q

What are the 2 main products of the first phase of the PPP?

A

Ribose 5-phosphate and Xylulose-5-phosphate

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8
Q

What are the intermediates between the oxidative decarboxylation of glucose 6-phosphate to ribulose 5-phosphate (6C to 5C)? PPP?

A

6-phsphoglucono-delta-lactone
then phosphogluconate

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9
Q

What carriers and small molecules are produced in the 1st, 2nd and 3rd step of converting G6P to ribulose 5-phosphate? PPP

A

1st = NADPH
2nd = H2O used to produce H+
3rd = NADPH and CO2

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10
Q

What enzyme is used in the first step of the conversion of G6P to ribulose 5-phosphate?

A

glucose 6-phosphate dehydrogenase

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11
Q

What enzyme is involved in the 2nd step in the oxidative decarboxylation of G6P to ribulose 5-phosphate?

A

lactonase

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12
Q

What enzyme is involved in the 3rd step in the oxidative decarboxylation of G6P to ribulose 5-phosphate?

A

6-phosphogluconate dehydrogenase

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13
Q

Which product of the first phase of the PPP can be diverted to other pathways?

A

Ribose -5- phosphate

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14
Q

Which enzyme is used in the reversible reaction producing ribose 5-phosphate in the first stage of the PPP?

A

phosphopentose isomerase

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15
Q

Which reaction does the enzyme phosphopentose epimerase catalyse in the PPP?

A

ribulose 5-phosphate to xylulose 5-phosphate

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16
Q

How many reactions are involved in phase 2 of the PPP?

A

3

17
Q

What is the name of the 7C and 3C molecule produced in phase 2 of the PPP?

A

Sedoheptulose 7-phosphate
Glyceraldehyde 3-phosphate

18
Q

What’s the name of the 4C molecule produces in phase 2 of the PPP?

A

erythrose 4-phosphate

19
Q

What’s the name of the 6C molecule produced in phase 2 of the PPP?

A

fructose 5-phosphate

20
Q

Ribose 5-phosphate (5C) and Xylulose 5-phosphate (5C) combine at the end of phase 1 of the PPP, does this produce 7C and 3C then 4C and 6C or the other way round?

A

Correct way round

21
Q

In phase 2 of the PPP, 4C and 5C combine to produce which two molecules? (name and carbon number)?

A

3C GLyceraldehyde 3-phosphate
6C Fructose 6-phosphate

22
Q

Which two enzymes are involved in phase 2 of the PPP?

A

Transketolase and Transaldolase

23
Q

Which enzyme in phase 2 of the PPP has a coenzyme? and what is the coenzyme?

A

Transketolase has a TPP coenzyme

24
Q

Which products of phase 2 of the PPP are glycolysis intermediates?

A

Glyceraldehyde 3-phosphate (3C)
Fructose 6-phosphate (6C)

25
Q

Which 5C product of phase 1 of the PPP combines with the phase 2 4C molecule erythrose 4-phosphate to produce 3C and 6C?

A

Xylulose 5-phosphate