Penicillins and Beta lactams Flashcards
Name the 5 major penicillins
1) Penicillin G
2) Amoxicillin
3) Ampicillin
4) Oxacillin
5) Nafcillin
Name the penicillinase resistant penicillins
oxacillin and nafcillin
Name 3 penicillins combined with beta lactamase inhibitors
1) Ampicillin-sulbactam (AmpSulbactam)
2) Amoxicillin-clavulanic acid (AmoxClav)
3) Piperacillin-tazobactam (PipTazo)
Name the 4 Class A beta lactamases and the active site
Active site: Serine
TEM
SHV
CTX
KPC
Name the 2 Class C beta lactamases and the active site
AMP
CMY
Active site: Serine
Name the Class D beta lactamase and active site
OXA
Serine
Name the Class B beta lactamases and active site
Active site: Zn 2+
NDM
VIM
IMP
What are Class A, C, and D beta lactamases inhibited by?
avibactam
What are Class B beta lactamases inhibited by?
EDTA and Aztreonam
Name the 3 extended spectrum B-lactamases
SHV (common in Enterobactereales) inhibited by clavulanic acid
TEM (some are ESBL others are narrow spectrum) inhibited by clavulanic acid
CTX (unpredictable spectrum) inhibited by tazobactam
What are the most common carbapenemases? (5)
Serine:
KPC: Klebsiella pneumoniae carbapanamase
OXA: oxacillinase
Zinc (Metallo-B-lactamases)
NDM: New Delhi metallo-B-lactamase
VIM: Verona integron mediated metallo-B-lactamase
IMP: imipenemase
Which organisms may carry KPC most often?
Klebsiella and E. coli
Which organisms may carry OXA most often?
Acinetobacter
Which organisms may carry NDM most often?
Klebsiella and E. coli
Which organisms may carry VIM most often?
Pseudomonas and Enterobactereales
