Penicillins Flashcards
How does fosfomycin inhibit cell wall synthesis?
Fosfomycin prevents the reduction of NAG to NAM and prevents transglycosylation. It stops one of the first steps in peptidoglycan synthesis
5 points antibiotics can target peptidoglycan synthesis:
- Transglycosylation
- Transpeptidation
- NAG-NAM reduction
- AA mimicry
- Transportation out of the cell
How does cycloserine inhibit cell wall synthesis?
Cycloserine is a structural analog of D-ala (part of the pentapeptide chain)
What part of peptidoglycan synthesis does bacitracin inhibit?
Bacitracin interferes with the transportation of the peptidoglycan subunits across the inner cell membrane
How do glycoproteins such as vancomycin inhibit cell wall synthesis?
Vancomycin sterically inhibits the addition of subunits to the NAG/NAM backbone
What are the four classes of penicillins?
Natural penicillins, penicillinase resistant penicillins, extended spectrum penicillins, antipseudomonal penicillins
What ICWS antibiotics are beta-lactams?
Penicillins, cephalosporins, monobactams, carbapenems
What other drugs (non beta lactams) are ICWS?
Cycloserine, vancomycin, fosfomycin, and bacitracin
What are the natural penicillins and their mode of administration?
- Penicillin G - IV,IM, PO?
- Benzathine penicillin - IM
- Procaine Penicillin G - IM
- Penicillin V - PO (acid resistant)
List the penicillinase resistant penicillins and their mode of administration?
- Nafcillin - IV, IM
- Oxacillin - PO
- Dicloxacillin - PO
- Methicillin -testing only!
List the extended spectrum penicillins and the mode of administration
- Ampicillin - PO
- Amoxicillin - PO
- Bacampicillin
Characteristics of natural penicillins:
- Best G+ coverage (includes anaerobes)
- Some G- coverage
- Inactivated by penicillinase
- Not antipseudomonal
- Renal excretion
- Poor CNS penetration
Characteristics of penicillinase resistant penicillins:
- Less G+ coverage
- Some G- coverage
- Resistant to penicillinase
- Not antipseudomonal
- Some are acid resistant
- Liver metabolism and renal excretion
- DOC-penicillin resistant staphylococcus aureus (MSSA)
- -> 20% will also be methicillin resistant
Characteristics of the extended spectrum penicillins:
- Lower G+ activity
- Extended G- activity
- Not antipseudomonal
- Inhibited by penicillinase
- Urinary excretion
- Acid resistant
- DOC- lysteria infections
* **ampicillin rash is not an allergic reaction. No need to stop the antibiotic
Characteristics of antipseudomonal penicillins:
- Similar coverage to extended spectrum penicillins
- Most often used for pseudomonas aeruginosa and acetinobacter infections
- Often used in combination with aminoglycosides
- Tend to be acid sensitive
- Renal excretion
- Penicillinase sensitive