Pemphigus vulgaris Flashcards
1
Q
Which antibodies lead to the development of pemphigus vulgaris?
A
Antibodies against desmoglein 3
2
Q
What are the exacerbating factors for pemphigus vulgaris?
A
Drugs (ACE-Is, penicillamine, penicillin, phenobarbital), viruses, UV radiation, diet (onion, garlic, leeks)
3
Q
What are the clinical features of pemphigus vulgaris?
A
- Mucosal ulceration; oral involvement in 50-70%
- Skin blistering - flaccid, easily ruptured vesicles and bullae
- Lesions are typically painful, but not itchy
- After crusting –> hyperpigmentation but without scarring
- +ve Nikolsky’s sign
4
Q
What is the typical finding on biopsy is seen in pemphigus vulgaris?
A
Acantholysis: loss intracellular between keratinocytes
5
Q
What is the management of pemphigus vulgaris?
A
- Steroids
- Immunosuppressants
