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Vesiculobullous diseases > Pemphigoid: BP, Cicatricial > Flashcards

Pemphigoid: BP, Cicatricial Flashcards

1
Q

autoantigen BP

A
  1. BPAG2 (collagen XVII) 180 kDa NC16A domain (transmembrane hemidesmosomal protein)
  2. BPAG1 230 kDa cytoplasmic plaque protein
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2
Q

drugs that can induce BP

A 
lasix
PCN-derivatives 
captopril
penicillamine 
gold
sulfasalazine
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3
Q

level of split/histology of BP

A

subepidermal

look for eos (with lymphs and PMNs)

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4
Q

IIF on SSS shows (for BP)

A

binding to epidermal side (cicatricial with anti-epiligrin CP binds to dermal side)

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5
Q

DIF of BP

A

linear C3 and IgG at BMZ

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6
Q

cicatricial pemphigoid autoantigen

A 
BPAG2 (collagen XVII)
Beta4 subunit of a6B4 integrin (OCULAR dz only)
laminin 5 (aka epiligrin) (a/w inc risk cancer)
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7
Q

IIF on SSS of cicatricial pemphigoid

A

binding to epidermal side BUT anti-laminin 5/epiligrin binds to dermal side

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Vesiculobullous diseases (6 decks)

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