PEM Tox

Question 1

how does CO poisoning affects hemoglobin’s ability to bind or release oxygen?

Answer 1

decreases ability to release the oxygen at the tissue level

Question 2

cyanide mechanism of toxicity

Answer 2

binds to the Fe3 in the mitochondria and impairs oxidative phosphorylation leading to aerobic metabolism and lactic acid accumulation

Question 3

how does Cyanide poisoning affects hemoglobin’s ability to bind or release oxygen?

Answer 3

decreases ability to release the oxygen at the tissue level

Question 4

labs in cyanide poisoning

Answer 4

acidemia, marked lactate elevation (often more than 8 to 10 mmol/L), and a diminished arterial–venous oxygen difference

Question 5

Digoxin over dose symptoms

Answer 5

Hyperkalemia and heart block

Question 6

Digoxin overdose work up

Answer 6

EKG, bmp, mag, UA and serum drug concentrations

Question 7

Digoxin tx

Answer 7

Activated charcoal, digoxin specific antibodies