PELVIC & OVARIAN DISORDERS Flashcards

1
Q

ovarian torsion

A

complete or partial rotation of ovary on its ligamentous supports

  • often impedes blood supply

⦁ ovary typically rotates around both the infundibulopelvic ligament & utero-ovarian ligament

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2
Q

when fallopian tube twists along with the ovary - torsion = called

A

adnexal torsion

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3
Q
  • 50-60% of patient’s ovarian torsion = was secondary to an
A

ovarian mass

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4
Q

_______ ovarian torsion more common

A

right more common than left

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5
Q

why is right ovarian torsion more common than left

A

perhaps because right utero-ovarian ligament is longer than the left, or that presence of sigmoid colon on left side helps prevent it

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6
Q

presentation of ovarian torsion

A

⦁ abrupt onset of acute, severe, unilateral, lower abdominal & pelvic pain
⦁ often associated with N/V
⦁ often the severe pain comes on suddenly with a change in position
⦁ a unilateral, extremely tender adnexal mass is found in > 90% of patients
⦁ many patients noted intermittent previous episodes of similar pain for several days to several weeks

  • often confused with appendicitis
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7
Q

Diagnosis of ovarian torsion

A

color flow Doppler US

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8
Q

Treatment for ovarian torsion

A

⦁ early diagnosis = can often be managed with conservative surgery

⦁ if necrosis is developing = need unilateral salpingo-oophorectomy = TOC (removal of FT & ovary)

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9
Q

what is chronic pelvic pain (CPP)?

A

Pain of AT LEAST 6 MONTHS duration that occurs below the umbilicus

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10
Q

CPP = chronic pelvic pain is Pain of AT LEAST __________ duration that occurs below the umbilicus

A

6 MONTHS

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11
Q

Chronic Pelvic Pain

A
  • episodic-cyclic, recurrent pain that is interspersed with pain-free intervals
  • or continuous non-cyclic pain

often times the etiology is not found or the treatment of the presumed etiology fails: and pain becomes the illness

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12
Q

most common gynecological cause of chronic pelvic pain

A

ENDOMETRIOSIS

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13
Q

ETIOLOGIES OF CPP

A
ETIOLOGIES OF CPP
o EPISODIC
⦁	dysparuenia
⦁	midcycle pelvic pain (Mittelschmerz)
⦁	dysmenorrhea
o CONTINUOUS
⦁	Endometriosis (mostly cyclic pain)
⦁	Adenomyosis
⦁	Chronic salpingitis (PID)
⦁	Adhesions
⦁	Loss of pelvic support
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14
Q

RISK FACTORS FOR CPP

A
⦁	hx of sexual abuse/trauma
⦁	previous pelvic surgery
⦁	hx of PID
⦁	endometriosis
⦁	personal or family hx of depression
⦁	hx of other chronic pain syndromes (fibromyalgia)
⦁	hx of alcohol / drug abuse
⦁	sexual dysfunction
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15
Q

HISTORY OF CPP

A
  • pain duration > 6 months
  • incomplete relief from most treatments - including surgery & non-narcotic analgesics
  • significantly impairs work/home
  • signs of depression such as early morning awakening, weight loss, anorexia
  • pain out of proportion to pathology
  • hx of childhood abuse/rape/sexual trauma
  • hx of substance abuse
  • current sexual dysfunction
  • previous consultation with 1+ providers & dissatisfaction with treatment/management
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16
Q

more of an acute process and not CPP

A
  • fever
  • vomiting
  • rebound tenderness
  • increased abdominal pain on palpation with tension of rectus muscles
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17
Q

straight leg raise on PE with CPP

A

⦁ decreased pain = think pelvic origin

⦁ increased pain = think abdominal wall or myofascial origin

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18
Q

PE for CPP

A
  • inspect & note any well healed scars (may be CPP from surgery)
  • palpate for any hernias (incisional, femoral, inguinal) & masses

o Do speculum exam; cervicitis?
o Bimanual / rectal exam - any masses, abnormal bleeding, tender
⦁ cervical motion tenderness = think acute process - such as PID, ectopic, or ruptured ovarian cyst
⦁ nonmobility of uterus = presence of pelvic adhesions
⦁ cul-de-sac nodularities = endometriosis

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19
Q

labs for CPP

A

⦁ serum hcg
⦁ UA
⦁ wet prep/KOH
⦁ cervical cultures / Gonorrhea & chlamydia
⦁ CBC with diff
⦁ ESR
⦁ Stool guiac - if positive = do GI workup

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20
Q

imaging for CPP

A

⦁ ULTRASOUND - to identify pelvic masses

⦁ Diagnostic Laparoscopy - may identify: acute or chronic salpingitis, ectopic pregnancy, hydrosalpinx, endometriosis, ovarian tumors/cysts, torsion, appendicitis, adhesions

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21
Q

CPP TREATMENT

A
  • treat the underlying cause = #1 treatment
  • psychosocial interventions
  • Meds
    ⦁ avoid long-term narcotic use
    ⦁ NSAIDS
    ⦁ antidepressants
    ⦁ oral contraceptives

o Surgical Interventions
⦁ diagnostic & therapeutic laparoscopy
⦁ hysterectomy

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22
Q

PID

A
  • **ASCENDING spread of bugs - spread of micro-organisms from vagina or cervix to the endometrium / fallopian tubes / ovaries & contiguous structures
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23
Q
  • **ASCENDING spread of bugs - spread of micro-organisms from vagina or cervix to the endometrium / fallopian tubes / ovaries & contiguous structures
A

PID

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24
Q

Pain of AT LEAST 6 MONTHS duration that occurs below the umbilicus

A

CHRONIC PELVIC PAIN

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25
Q

Outpatient visits for PID have declined, primarily due to aggressive __________ screening

A

chlamydia

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26
Q

RISK FACTORS FOR PID

A
⦁	young age at onset of sexual activity
⦁	new, multiple, or symptomatic partners
⦁	unprotected sex
⦁	hx of PID
⦁	gonorrhea/chlamydia or hx of gonorrhea/chlamydia
⦁	current vaginal douching
⦁	insertion of IUD (within first 3 weeks)
⦁	BV
⦁	sex during menses
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27
Q

most cases of PID are _______

A

polymicrobial

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28
Q

MOST COMMON PID PATHOGENS

A

⦁ N. gonorrhoeae - 30-40%
⦁ C. trachomatis - 20-40%
⦁ others = streptococci, staphylococci, enterobacteria, anaerobes, gardnerella vaginalis, strep agalactiae

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29
Q

PATHWAY OF ASCENDING INFECTION (PID)

A
  • cervicitis –> endometritis –> salpingitis / oophoritis / tubo-ovarian abscess –> peritonitis
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30
Q

COMPLICATIONS WITH PID

A
  • approx 10-20% of women with a single PID episode will experience sequelae, including
    ⦁ ectopic pregnancy
    ⦁ infertility
    ⦁ tubo-ovarian abscess
    ⦁ chronic pelvic pain
    ⦁ Fitz-Hugh-Curtis syndrome (perihepatitis)
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31
Q

Tubal infertility occurs in 50% of women after ________________ episodes of PID

A

3

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32
Q

____________ occurs in 50% of women after 3 episodes of PID

A

tubal infertility

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33
Q

MINIMUM CRITERIA FOR DIAGNOSIS OF PID

A
  • uterine/adnexal tenderness

or

  • cervical motion tenderness (positive chandelier sign)
34
Q

DIAGNOSING PID

A
  • uterine/adnexal tenderness or…
  • cervical motion tenderness (positive chandelier sign) - throw hands up from pain

OTHERS

  • fever
  • abnormal cervical or vaginal mucopurulent discharge
  • WBC presence on saline wet prep
  • elevated ESR & CRP
  • gonorrhea or chlamydia test positive
35
Q
  • have fever, adnexal/cervical tenderness, mucopurulent vaginal or cervical discharge, WBCs on saline wet mount, gonorrhea or chlamydia test is positive, elevated ESR/CRP
A

PID

36
Q

cervical motion tenderness / chandelier sign

A

PID

37
Q

treatment for PID

A

⦁ Ceftriaxone 250mg IM (gonorrhea) + Azithromycin 1g qw x 2 weeks (chlamydia)

or

⦁ Ceftriaxone 250mg IM (gonorrhea) + Doxycycline 200mg BID x 14 days (chlamyd)

  • treatment should be done ASAP to prevent long term sequelae
  • need to treat sexual partners if + for Gonorrhea/chlamydia
  • educate pt to avoid sexual activity until she & partner complete treatment
  • close follow up to ensure clearance
38
Q

follow up for PID

A
  • patients should have substantial improvement within 72 hours
  • pts who don’t improve usually require hospitalization, additional diagnostic tests, and surgery
  • some recommendations to rescreen for chlamydia & gonorrhea 4-6 weeks after completing therapy
39
Q

PID CRITERIA FOR HOSPITALIZATION

A

⦁ Inability to exclude surgical emergencies
⦁ Pregnancy
⦁ Non-response to oral therapy
⦁ Inability to tolerate an outpatient oral regimen
⦁ Severe illness, looks septic, nausea and vomiting, high fever or tubo-ovarian abscess
⦁ HIV infection with low CD4 count

40
Q

PARENTERAL REGIMENS FOR PID

A

⦁ Cefotetan or Cefoxitin PLUS Doxycycline (A)

⦁ Clindamycin + Gentamycin (B)

41
Q

parenteral regimen A for PID

A

Cefotetan or Cefoxitin PLUS Doxycycline = IV

  • continue this regimen for at least 24 hours after substantial clinical improvement
  • then take doxy x 14 days
42
Q

parenteral regimen B for PID

A

Clindamycin + Gentamycin (B) = IV

  • continue this regimen for at least 24 hours after substantial clinical improvement
  • then take doxy or clinda x 14 days
43
Q

treating male partners of women with PID

A
  • male sex partners of women with PID should be examined/treated if they had sexual contact with pt during 60 days preceding patient’s onset of symptoms
  • male partners of women with PID from gonorrhea or chlamydia = often asymptomatic
    ⦁ should be treated empirically against both gonorrhea & chlamydia, regardless of apparent etiology of PID or pathogens isolated from infected woman
44
Q

SCREENING FOR CHLAMYDIA IN PID PREVENTION

A
  • to reduce incidence of PID = screen & treat for chlamydia!
  • annual chlamydia screening recommended for
    ⦁ sexually active women 25 and under
    ⦁ sexually active women > 25 at high risk
  • screen pregnant women in the 1st trimester
45
Q

Most common cause of androgen excess and hirsutism in women

A

PCOS

46
Q

Most common hormonal disorder among women of reproductive age

A

PCOS

47
Q

Highly associated with insulin resistance

A

PCOS

48
Q

PCOS is highly associated with

A

insulin resistance

49
Q

PCOS SYMPTOMS

A
⦁	oligomenorrhea (infrequent menses) or amenorrhea
⦁	anovulation
⦁	obesity
⦁	acne
⦁	hirsutism
⦁	infertility
50
Q

DIAGNOSIS OF PCOS

A

no single definitive test for PCOS because no exact cause of the condition has been established (remember, this is a syndrome)

o ROTTERDAM CRITERIA = diagnosis of PCOS can be made with 2/3 features (once related disorders have been excluded)
⦁ Oligomenorrhea or anovulation
⦁ clinical and or biochemical signs of hyperandrogenism (acne & hirsutism)
⦁ Polycystic ovaries on US

PANCE PEARLS SAYS PCOS TRIAD =

1) amenorrhea
2) hirsutism/acne
3) obesity

51
Q

ROTTERDAM CRITERIA

A

to diagnose PCOS = need 2/3 features (once related disorders have been excluded)

⦁ Oligomenorrhea or anovulation
⦁ clinical and or biochemical signs of hyperandrogenism (acne & hirsutism)
⦁ Polycystic ovaries on US

52
Q

what does insulin resistance have to do with PCOS

A

insulin resistance leads to compensatory hyperinsulinemia

increased insulin levels can stimulate androgen production by stromal cells in the ovaries

53
Q

ETIOLOGY OF PCOS

A

Precise etiology unknown, likely multiple systems affected:

1) Defect in hypothalmic-pituitary axis
⦁ causing the release of excessive LH by anterior pituitary –> increased androgen production in the ovary –> elevated local concentrations of androgens –> inhibits ovulation

2) Defects of ovaries –> androgen overproduction

3) Defect in insulin sensitivity –> leads to insulin resistance and compensatory hyperinsulinemia
⦁ Increased insulin levels can stimulate androgen production by stromal cells of the ovary.

4) Genetic factors can also contribute

54
Q

PCOS & insulin resistance = presence of

A

acanthosis nigricans

Fasting blood sugar to fasting insulin ratio should be greater than 4.5 in a normal patient… anything below that is considered insulin resistant

55
Q

70% of women with PCOS have

A

insulin resistance

56
Q

in PCOS: As little as ____% weight reduction can be effective in restoring regular ovulation and menses

A

10%

57
Q

ULTRASOUND FINDINGS IN PCOS

A
  • multiple follicles around the periphery of the ovary (this is a finding, not a cause) - because 25% of normal women can have this, and not all women with PCOS have cystic ovaries
  • ultrasound is NOT necessary to make a PCOS diagnosis
58
Q

is an ultrasound necessary to diagnose PCOS

A

no

59
Q

multiple follicles around the periphery of the ovary on ultrasound

A

PCOS

“string of pearls”

60
Q

lab tests for PCOS

A
⦁	testosterone
⦁	androstenedione
⦁	DHEAS
⦁	17 hydroxyprogesterone
⦁	prolactin
⦁	TSH
⦁	HCG
61
Q

FITZ-HUGH-CURTIS SYNDROME

A

perihepatitis

complication of PID

62
Q

LABS FOR PCOS

A
⦁	testosterone
⦁	androstenedione
⦁	DHEAS
⦁	17 hydroxyprogesterone
⦁	prolactin (elevated prolactin prevents ovulation)
⦁	TSH
⦁	HCG
⦁	fasting blood sugar
⦁	fasting insulin level
⦁	LH/FSH
63
Q

WHY TREAT PCOS

A

⦁ Decrease risk of endometrial hyperplasia and cancer
⦁ Possibly decrease risk of breast CA
⦁ Decrease all sequella that occur with DM
⦁ Patient satisfaction***

64
Q

PCOS TREATMENT

A

1) diet & exercise
2) OCPs
3) Spiro
4) Metformin
5) Clomiphene (Clomid)

OCPS = suppress LH and therefore suppress circulating androgens.
Also regulates periods (but not so good if you want to have children)

SPIRO = antiandrogen (helps with hirsutism) - diuretic but also blocks effects of dihydrotestosterone too
⦁ pregnancy category D
⦁ monitor for hyperkalemia
⦁ may be tumorigenic

METFORMIN = helps with insulin resistance & weight loss

CLOMIPHENE = for those trying to become pregnant and are still anovulatory after diet, exercise & metformin have been tried**
⦁ binds to estrogen receptors in hypothalamus - creates a state of hypoestrogenicity –> enhanced GnRH release –> increased gonadotropin release –> stimualtes ovulation

65
Q

treatment for women with PCOS who are trying to get pregnant and are still anovulatory after diet, exercise, and metformin

A

Clomiphene (Clomid)

66
Q

MOA OF CLOMID (CLOMIPHENE)

A

binds to estrogen receptors in hypothalamus - creates a state of hypoestrogenicity –> enhanced GnRH release –> increased gonadotropin release –> stimualtes ovulation

67
Q

⦁ Ovaries are palpable less frequently in reproductive age women taking

A

OCPs

68
Q

⦁ The older the woman, the more likely a tumor is

A

malignant

69
Q

⦁ The ovaries should NOT be palpable in the ___________ group, nor should they be palpable in the _________ group

A

premenarchal

postmenopausal

70
Q

arises as a result of normal ovarian physiology

A

ovarian cysts

71
Q

OVARIAN CYSTS

A
  • fluid-filled sacs that develop in or on the ovary
  • ovarian cysts occur commonly in women of all ages
  • some women with ovarian cysts have pain or pelvic pressure, while others have no symptoms
72
Q

HOW DOES A FOLLICULAR CYST FORM

A

If an ovarian follicle fails to rupture during maturation, ovulation does NOT occur, and a follicular cyst may develop

May be symptomatic or asymptomatic

Clinically significant if large enough to cause pain or if it persists beyond one menstrual interval

Characteristics on physical exam:
mobile, cystic, adnexal mass

73
Q

MANAGEMENT OF FOLLICULAR CYST

A
  • follicular cysts usually spontaneously resolve

MANAGEMENT = reevaluation in 6-8 weeks to ensure the cyst has resolved. May order transvaginal US as needed

  • OCP may be given to suppress gonadotropin stimulation of the cyst
74
Q

BENIGN OVARIAN TUMORS ex:

A

⦁ Benign epithelial cell tumors
⦁ Benign germ cell tumors (benign cystic teratoma = dermoid cyst)
⦁ Benign Stromal cell tumors = sertoli-leydig cell tumor

75
Q

BENIGN OVARIAN NEOPLASMS

A

**benign ovarian neoplasms are more common than malignant tumors of the ovary in ALL AGE GROUPS.

The chance for malignancy transformation increases with age –> warrants surgical treatment because of their potential to transform to malignancy.

Surgical treatment may be conservative for benign tumors, especially if future pregnancy is desired

76
Q

The mortality rate from _________ cancer is higher than that of all other gynecologic cancers

A

ovarian

why? - because they’re found late!

77
Q

ovarian cancer happens in the ________ decades

A

5th-6th decades most often

78
Q

Use of ______ x _______ years decreases lifetime risk of ovarian cancer by half

A

OCPs x 5 years

The suppression of ovulation tends to have a protective effect

79
Q

RISK FACTORS FOR OVARIAN CANCER

A

⦁ aging
⦁ postmenopause
⦁ periods of prolonged ovulation without pregnancy (so no kids)
⦁ having 1st degree relative with ovarian, colon or breast cancer
⦁ BRCA 1 or BRCA 2 gene mutation

80
Q

OVARIAN CANCER SCREENING GUIDELINES

A
  • no effective method of mass screening has been developed yet
  • routine ultrasound & CA-125?
    ⦁ neither is recommended routinely
    ⦁ high expense, poor sensitivity & reliability

ANNUAL BIMANUAL EXAM is recommended by ACOG

81
Q

*****90% of ovarian malignancies are of the

A

EPITHELIAL CELL TYPE*****