peer teaching Flashcards
What are the SE of L-dopa?
Postural hypotension on starting treatment
Confusion, hallucinations
L-dopa induced dyskinesias
On-off effect: fluctuations in motor performance between normal function
(on) and restricted mobility (off).
Shortening duration of action of each dose (i.e. end-dose deterioration where
dyskinesias become more prominent at the end of the duration of action)
What should be used in conjunction with L-dopa to reduce SE?
Dopa decarboxylase inhibitor (e.g. carbidopa or benserazide)
In terms on incontinence, what anti-muscaranics are best and worst for delirium?
oxybutnin worst, try use solifenacin or trospium instead as don’t cross BBB and cause delirium
1st line laxative in the elderly?
1st line: bulk forming laxative eg ispaghula (fibergel) UNLESS an opioid then do docusate (osmotic and stimulant laxative)
What is c.diff cause by and what is the mx?
C.diff caused by cephalosporins, ciprofloxacin, clindamycin, amoxicillin/co-amox
Mx: metronidazole for 10-14 days
What is the immediate vs long-term mx of a TIA?
Immediate Management Plan:
ABCDE assessment
Aspirin (300 mg daily) started immediately (with PPI if indicated).
Specialist assessment and investigation within 24 hours of onset of symptoms
Specialist assessment within 1 week if suspected TIA more than 1 week ago.
Long-Term Management Plan (secondary prevention):
Lifestyle modification
Clopidogrel 75mg daily
Statins, antihypertensives if necessary.
Warfarin/NOACs if AF, mitral stenosis, dilated cardiomyopathy, recent big septal MI.
What heart conditions can cause a CVA?
Atrial fibrillation MI causing mural thrombus Infective endocarditis Aortic or mitral valve disease Patent foramen ovalee
Describe the Oxford/ Bamford classification of strokes
- unilateral hemiparesis and/or hemisensory loss of the face, arm & leg
- homonymous hemianopia
- higher cognitive dysfunction e.g. dysphasia
Total anterior circulation infarcts (TACI, c. 15%)
involves middle and anterior cerebral arteries
all 3 of the above criteria are present
Partial anterior circulation infarcts (PACI, c. 25%)
involves smaller arteries of anterior circulation e.g. upper or lower division of middle cerebral artery
2 of the above criteria are present
Lacunar infarcts (LACI, c. 25%)
involves perforating arteries around the internal capsule, thalamus and basal ganglia
presents with 1 of the following:
1. unilateral weakness (and/or sensory deficit) of face and arm, arm and leg or all three.
2. pure sensory stroke.
3. ataxic hemiparesis
Posterior circulation infarcts (POCI, c. 25%) involves vertebrobasilar arteries presents with 1 of the following: 1. cerebellar or brainstem syndromes 2. loss of consciousness 3. isolated homonymous hemianopia
WHat are sx of hypercalcaemia?
Bone pain, fractures (hyperPTH or
malignancy)
Renal stones (renal colic); renal
impairment (renal calcinosis);
polyuria, polydipsia, dehydration
(nephrogenic diabetes insipidus)
Drowsiness, delirium, coma, muscle
weakness, impaired cognition,
depression
Nausea, vomiting, weight loss,
anorexia, constipation, abdominal
pain.
HTN, shortened QT, arrhythmias.
What are sx of hypocalcaemia?
Paraesthesia (usually fingers, toes
and around mouth).
Tetany.
Carpopedal spasm (wrist flexion and fingers drawn together).
Muscle cramps
Seizures.
Prolonged QT
Laryngospasm; bronchospasm
What MMSE score supports a diagnosis of dementia?
MMSE <25 supports dementia. 25-27 is borderline.
<10 severe; 10-20 moderate; 21-24 mild.
What other cognitive assessment tools may be used for dementia?
Addenbrookes cognitive examination-III (ACE-III)
Montreal cognitive assessment (MoCA)
Abbreviated mental test score (AMT)
6-Item cognitive impairment test (6CIT)
General practitioner assessment of cognition (GPCOG)
List 4 blood tests you would do to exclude treatable
causes of dementia.
Thyroid function tests
Syphilis serology (neurosyphilis)
Liver function tests (hepatic encephalopathy; alcoholism)
Vitamin B12, thiamine (B1) and folate levels
What is Donepezil and what types of dementia can it be
used to treat?
Donepezil is an acetylcholinesterase inhibitor; used only in
Alzheimer’s disease. (Others ACh-ase inhibitors: rivastigmine
and galantamine)
Alternative medication: memantine, a N-methyl-D-aspartate
(NMDA)-receptor antagonist which blocks glutamate. (Only in
moderate to severe Alzheimer’s)
What does the comprehensive geriatric assessment
entail?
1) Medical
Doctors, nurses, pharmacist,
dietician, speech & language
therapist
2) Mental Health
Doctors, nurses, psychologist, OT
3) Functional Capacity OT, PT, S&LT eg Activities of Daily Living Gait & Balance Activity/Exercise Status
4) Social & Environmental
OT, Social worker
What is important not to give in LBD?
neuroleptics should be avoided in Lewy body dementia as patients are extremely sensitive and may develop irreversible parkinsonism!!
When should alendronic acid be stopped?
After a 5year period for oral bisphosphonates (3years for IV zoledronate), treatment should be re-assessed for ongoing treatment, with an updated FRAX score and DEXA scan.
BUT If high risk continue, e.g. of high risks: Glucocorticoid therapy Age >75 Previous hip/vertebral fractures Further fractures on treatment High risk on FRAX scoring T score
what is second line after alendronic acid for OP?
risedronate or etidronate
Name the mechanism of action and adverse effects of alendronic acid
Bisphosphonates are analogues of pyrophosphate, a molecule which decreases demineralisation in bone. They inhibit osteoclasts by reducing recruitment and promoting apoptosis.
Adverse effects
oesophageal reactions: oesophagitis, oesophageal ulcers (especially alendronate)
osteonecrosis of the jaw
increased risk of atypical stress fractures of the proximal femoral shaft in patients taking alendronate
Describe the meaning of the T scores in OP
- 1 to +1 = healthy
- 2.5 to -1 = osteopenia
> -2.5 = osteoporosis
what is malnutrition?
BMI <18.5kg/m2
Unintentional weight loss >10% last 3-6mths
BMI <20kg/m2 AND unintentional weight loss >5% within last 3-6mths
Describe the physiological signs of refeeding syndrome
CVS: arrhythmia, HT, CHF
GI: abdo pain, constipation, vomiting, anorexia
MUSC: weakness, myalgias, rhabdomyolysis, osteomalacia
RESP: SOB, ventilator dependence, respiratory muscle weakness
NEURO: weakness, paraesthesia, ataxia
METABOLIC: infections, thrombocytopaenia, haemolysis, anaemia
hypophosphataemia; hypokalaemia; hypomagnesaemia
hyperglycaemia; thiamine deficiency (erthryocyte transketolase or thiamine level)
OTHER: ATN, Wernicke’s encephalopathy, liver failure
What can cause a rash in the EBV caused infection?
A maculopapular, pruritic rash develops in around 99% of patients who take amoxicillin whilst they have Infectious Mononucleosis (glandular fever)
What is pencillamine used for?
it is used as a copper
chelating agent in Wilson’s disease NOT a penicillin
What ix if used for monitoring progress in cancer?
a positron emission tomography (PET) scan. This uses a radioactive tracer to show
the areas of high uptake and therefore areas of active malignancy.
what sx count as the B sx of leukaemia B cancer?
unexplained fever, unexplained weight loss, and drenching sweats (particularly at
night)
RF for DDH?
Females are 6x more likely to have developmental dysplasia of the hip
(DDH). Breech birth, high birth weight, oligohydramnios, and prematurity are all risk factors.
What is the cheese effect and what antidepressants does it effect?
This is to avoid the ‘cheese effect’ of eating tyramine-rich foods with a Monoamine oxidase inhibitor
antidepressant, as it can lead to a build up of tyramine and hypertension. Phenelzine is an example of a
MAO inhibitor.
describe mx for acute mania vs acute bipolar depressive episode vs long ter mx of bipolar
The first line treatment for an acute manic or mixed episode in BAD is an atypical antipsychotic. For a
depressive episode it’s an atypical antipsychotic plus an SSRI, usually Olanzapine and Fluoxetine.
However, for long term maintenance, Lithium is the first line. Valproate, carbamazepine, Chlorpromazine can be
added in if this doesn’t work.
What kind of tremor is seen in lithium therapeutic levels vs OD? what are the other sx of lithium toxicity?
A fine tremor is generally regarded as a side effect of Lithium in the therapeutic range,
whereas a coarse tremor would develop if it was in the toxic range.
Ataxia, Seizure, Slurred speech, Vomiting
what is the first line drug for an alcohol detox?
Chlordiazepoxide
+ can also give thiamine (pabrinex) in detox
What is the ICD-10 classification of delirium?
- ) Impairment of consciousness and attention
- ) Global disturbance in cognition
- ) Psychomotor disturbance
- ) Disturbance of sleep-wake cycle
- ) Emotional disturbances
what ix results would you see for NMS?
Raised CK (creatine kinase) –> due to muscle rigidity
● Raised white cell count
● Deranged LFT’s
● Acute renal failure –> abnormal U&E’s
● Metabolic acidosis –> low pH, low HCO3
How do you tx PID in response to the coil?
Start antibiotics immediately
- Prescribe doxycycline, metronidazole, and IM ceftriaxone (broad-spectrum management)
- Leave in a recently inserted coil. If there is no response within 48hrs to the antibiotics,
remove the coil and prescribe any other necessary emergency contraceptives
What abx should be used for UTI in pregnancy ?
Nitrofurantoin should be avoided in the 3rd
trimester as there is a risk of haemolytic
anaemia in neonate with G6PD deficiency
Trimethoprim is a folate antagonist and so can cause neural tube defects if used in the 1st
trimester
cephalosporins and amoxicillin safe at any point in pregnancy
What is the first line drug tx for stress incontinence?
Duloxetine
What is the 1st, 2nd and 3rd line tx for endometriosis?
1st: NSAIDs
2nd: COCP
3rd: IUD
A 21 year old woman has acute onset of pain in her right iliac fossa pain. She has marked
tenderness upon palpation in this area, some voluntary guarding, but no rebound tenderness. She has
not vomited and denies feeling nauseous. Her temperature is 37.2°C, her pulse rate is 80 bpm, and her
blood pressure is 115/80 mmHg. Her pregnancy test is negative. An ultrasound scan shows a 7 cm
right-sided haemorrhagic ovarian cyst with no free fluid. Which is the single most appropriate initial
management?
needs to be
managed conservatively.
Most cysts presenting acutely will present with lower abdominal pain, but without signs of peritonism or
systemic upset. The absence of vomiting, peritonism, and a fever make torsion and appendicitis unlikely,
therefore no need to refer to the surgeons at this stage.
What is the mx of PROM?
antibiotics should be given for 10 days following premature preterm rupture
of membranes, or until the woman is in established labour, whichever is sooner.
1st line for chlamydia?
Chlamydia vs gonorrhoea?
1st line for candida?
-Doxycycline 100mg PO BD for 7 days
-gonorrhoea, unlike chlamdyia, classically causes ‘purulent’ vaginal
discharge, and doesn’t normally cause intermenstrual or post-coital bleeding
-Clotrimazole