Peds Uworld Flashcards
cyanosis and single S2 (most common cardiac defect of neonatal period)
in contrast, what is the most common after the neonatal period?
in contrast, what will present with shock due to impaired systemic perfusion?
transposition of the great vessels
after: ToF
shock: coarctation of aorta and hypoplastic left heart
recurrent skin/mucosal infections, periodontal disease, ^WBCs with neutrophil predominance, think?
Leukocyte adhesion deficiency
also: lack of umbilical cord separation and no pus
acute edema of face, extremities, genitals, trachea, abdominal organs without urticaria, think?
hereditary angioedemia
C1 inhibitor deficiency
leads to ^bradykinin and C2b (edema-producing factors)
most common cause of acquired form is from using ACE-i
recurrent infections with S. aureus, Serratia, Burkholderia, Aspergillus, think ? what test to get?
Chronic Granulomatous Disease: impaired oxidative burst, NADPH oxidase deficiency, get inf. with catalase+ organisms
think Cats Need PLACESS to Belch their Hairballs
Nocardia, Pseudomonas, Aspergillus, Candida, E. coli, Staph, Serratia, Burkholderia, H. pylori
get dihydrorhodamine 123 test (old: nitroblue)
partial albinism and recurrent cutaneous infections with S. aureus and S. pyogenes, think?
Chediak-Higashi
eczema, thrombocytopenia, recurrent infections, think?
Wiskott-Aldrich
impaired cytoskeleton changes in WBCs/plts
tx: SCT
fever, lethargy and signs of heart failure after a viral prodrome, think?
how to manage?
viral myocarditis
ICU due to risk of acute decompensation and fatal arrhythmia
+/- cardiomegaly and pulmonary edema on CXR
failure to thrive, recurrent infections of all types, low lymphocyte and T cell concentrations, think?
tx?
SCID
tx: stem cell transplant
recent Giardia infection and lobar pneumonia, consider ?
Bruton’s X-linked agammaglobulinemia: abnormal B lymphocyte maturation, at risk for sinopulmonary infections with encapsulated orgs (H. flu, S. pyogenes) due to imp. humoral response, and GI infections i.e. Giardia due to absence of IgA
contraindications to DTaP
anaphylaxis to vaccine ingredients
additional for pertussis part: progressive neurological disorder or encephalopathy within wk of vaccine
tx for long QT syndrome
B-blockers (propranolol) with pacemakers (except sotalol which blocks K+ channels)
electrolyte derangements that can cause prolonged QT
low Ca2+, low K+, low Mg2+
meds that can cause prolonged QT
macrolides, FQs, antipsychs, TCAs, SSRIs, methadone, oxy, zofran, quinidine, procainanmide, flecainide, amiodarone, sotalol
failure to thrive and recurrent respiratory and GI infections, chronic lung disease especially with Giardia, encapsulated bacteria, and enterovirus, think?
common variable immunodeficiency: B-cell differentiation impaired leading to decreased of all Igs
wheezing, coughing, dysphagia, biphasic stridor that improves with neck extension, think?
what improves with prone positioning?
vascular rings
prone: laryngomalacia (collapse of supraglottic structures during inspiration)
should you tx rheumatic fever with abx?
yes, PCN, as they are at risk of recurrent episodes and progression of rheumatic HD with repeated infection with GABS pharyngitis
what is never normal on neonatal EKG?
left axis deviation
if present + decreased pulmonary markings on CXR, think tricuspid atresia (hypoplasia of RV and pulm. outflow tract)
AOM orgs
S. pneumo, H. flu (not Hib), Moraxella
tx: amoxicillin, then augmentin
how to visualize laryngomalacia
direct laryngoscopy
tinea capitis tx
oral terbinafine, griseofulvin, itraconazole, fluconazole
bruise looking rash on minority kiddo
Mongolian spots, self-resolve during childhood
tinea corporis treatment
topical clotrimazole, terbinafine
2nd line: oral terbinafine, griseofulvin
hemangiomas in kiddos
strawberry (superficial)
vs cherry in adults
proptosis, ophthalmoplegia (pain with moving eyes), diplopia, think?
most common predisposing factor?
orbital cellulitis
bacterial sinusitis
neonate with blanching erythematous papules and pustules, think ?
erythema toxic neonatorum, benign and resolves within 2 weeks
bedwetting is normal before age ? and does not warrant treatment before this time
age 5
conjunctival injection, tarsal inflammation, pale follicles, think ?
trachoma: C. trachomatis A, B, C infection, leading cause of blindness worldwide
tx: oral azithromycin, may need eyelid sx
macrosomia, hypoglycemia, macroglossia, umbilical hernia/omphalocele, hemihyperplasia (1 side bigger than other) think ?
what to do next?
Beckwith-Wiedemann syndrome
get abdominal U/S to check for development of Wilms tumor or hepatoblastoma
in contrast, hypothyroidism may have macroglossia and umbilical hernia but not the other features
conjugated hyperbili + hepatomegaly in a newborn, think?
what to do next?
treatment?
biliary atresia
dx: abdominal U/S
tx: Kasai procedure
Reye syndrome:
presentation
labs
biopsy
n/v, encephalopathy, acute liver failure
^LFTs, ^PT, INR, PTT, ^NH3
microvesicular steatosis
in contrast: macrovesicular fatty changes are seen in alcoholic hepatitis and in NAFLD
1 month old with painless blood-streaked stools, eczema, regurgitating feedings, think?
milk- or soy-protein proctocolitis (enterocolitis/allergy)
intussusception dx? tx?
dx: U/S: “target sign”
tx: air or water-soluble contrast enema
see microcolon on contrast enema, think?
meconium ileus (at the level of the ileum), will also have thick "inspissated" meconium in contrast, Hirschsprung will have a "transition point" on contrast enema (typically rectosigmoid)
infant supplement timeline
all exclusively breastfed infants: 400 IU vitamin D 1st mo
breastfed + preterm infants: iron at birth-1 yr
can introduce pureed foods at 6 mos
can introduce cow’s milk at 1 yr
vitamin B6 (pyridoxine) deficiency presents how?
cheilosis, stomatitis, glossitis + irritability, confusion, depression
in contrast, riboflavin (B2) def. presents with cheilosis, stomatitis, glossitis + normocytic anemia, seborrheic dermatitis
15 day old with bilious vomiting and no gas seen on abdominal XR, think ? what to do next?
treatment?
malrotation with volvulus (both meconium ileus and Hirschsprung will have some gas, those are dx with contrast enema)
dx: upper GI series (barium swallow), will see Ligament of Treitz on right side of abdomen (malrotation), and “corkscrew” pattern (volvulus)
tx: Ladd procedure (fix bowel)
why do newborns get jaundiced?
at what levels to do exchange transfusion?
^hgb turnover/bili production
decreased UGT activity (conjugating enzyme)
sterile gut cannot break down bili to urobilinogen
if total bilirubin exceeds 20-25 mg/dL, otherwise can use phototherapy
where it is worrisome for batteries to get lodged
esophagus: needs immediate endoscopic removal to prevent mucosal damage and esophageal ulceration
if distal, 90% pass uneventfully
8 yo: RUQ pain, dark urine, jaundiced, ^bili (D, T), ^amylase, ^lipase, +extrahepatic cyst on u/s, think?
biliary cyst: cause cholestasis, palpable mass, +/- pancreatitis
tx: surgical resection
f/u: cholangiocarcinoma
“lead points” in intussusception
most common: hypertrophy of Peyer patches from recent illness
others: Meckel’s, HSP, celiac, tumor, polyps
other risk factors: rotavirus vaccine
intussusception tx
U/S guided air contrast enema or saline enema
barium enema not done due to risk of peritonitis from barium leakage if intestine perforates
rehydration for dehydrated kiddos
mild-mod: oral
mod-severe: IV NS, (dextrose-containing fluids may be used in maintenance, but not resuscitation)
weight loss, iron-def anemia, vesicular skin rash, T1 DM, think?
celiac
also associated with IgA deficiency, Downs, AI thyroiditis
constitutional growth delay
normal birth weight/height
then drop to 5th/10th % btw 6mo-3yrs, remains low until growth spurt, should reach normal adult height
giving GH will NOT help, they are not deficient
3 mo old: hypoglycemic, lactic acidosis, hyperuricemia, hyperlipidemia
doll-like face, thin extremities, hepatomegaly
Glucose-6-phosphatase deficiency (type 1 glycogen storage disease, von Gierke disease)
cannot convert glycogen to glucose
in contrast, glucocerebrosidase deficiency (Gaucher) presents with bone pain, cytopenias, hepatosplenomegaly, but NOT hypoglycemia and lactic acidosis
Turners hormone levels
low estrogen, progesterone (“streak ovaries”)
^FSH, LH (disinhibited feedback)
most common cause of congenital hypothyroidism ww
thyroid dysgenesis
in contrast, transplacental passage of TSH-rec Abs leads to hyperthyroidism
when to remove testes in AIS
after puberty so chica gets to full height but reduces risk of malignancy
lead poisoning tx
moderate 45-69: DMSA
severe 70+: DMSA + EDTA
precocious puberty with low LH levels that do not ^after GnRH stim test
nonclassic CAH (21-hydroxylase deficiency)
primary amenorrhea w/u
FSH if no breast development
if FSH decreased: pituitary MRI (prolactinoma)
if FSH increased: karyotype
abdominal pain, shock, hematemesis, metabolic acidosis + radio opaque areas on XR think ?
tx?
iron poisoning, tx with deferoxamine