PEDs Test 2 Flashcards

1
Q

The most common head injury in PEDS is?

A

concussion

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2
Q

Symptoms of concussion are:

A
  • fatigue
  • changes in behavior and mood
  • decreased school performance
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3
Q

Common causes of brain injury are:

A
  • falls
  • motor vehicle accidents
  • sports injuries
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4
Q

Absence seizures are characterized by:

SG 17

A
  • brief loss of consciousness
  • often without loss of motor control
  • cluster
  • last only a few seconds
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5
Q

___ seizures are the most common type of seizure for kids between the ages of 3 month and 3 years

SG 16

A

febrile

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6
Q

______ seizure is a seizure associated with a febrile illness who does not have a CNS infection

SG 16

A

febrile

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7
Q

initial treatment of febrile seizures__

SG 16

A

benzodiazepine

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8
Q

The goals of nursing management of the child with a head injury are to:

(list interventions)

A
  • maintain adequate ventilation, oxygenation, circulation
  • monitor and treat increased ICP
  • to minimize cerebral oxygen requirements
  • to support the child and family during the recovery phase
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9
Q

What are some nursing considerations for a child with head trauma?

A
  • place the child on bed rest
  • place the head of the bed elevated slightly and keep the head in the midline position
  • keep a quiet environment and turn the lights down
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10
Q

_____ is the most important nursing observation when caring for a child with head trauma

A

LOC

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11
Q

Signs of increased Intracranial Pressure:

A
  • irritability progressing to lethargy
  • High-pitched cry Increased frontooccipital circumference
  • Distended scalp veins
  • Poor feeding Crying when disturbed
  • Setting-sun sign
  • confusion
  • decreased responsiveness
  • decreased ability to follow commands
  • pupil dilation with decreased response to light
  • reduced spontaneous movement
  • deterioration in posture
  • cushing’s triad
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12
Q

meningitis in infants is associated with an approximately a _____ mortality rate.

A

50%

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13
Q

Prior to shunt placement, the focus of nursing care of a patient with hydrocephalus is making sure that the child and family are __________________________.

A

Physically and emotionally prepared for surgery.

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14
Q

most children with meningitis are seen with:

A
  • fever
  • chills
  • headache
  • vomiting that are quickly followed by alterations in sensorium
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15
Q

___ is the definitive diagnostic test of meningitis

A

lumbar puncture

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16
Q

VP shunts don’t usually last ______. They can be damaged through _________ or _______.

A

forever

rough play

trauma

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17
Q

The major complications of VP shunts are ________ and _________.

A

malfunction

infection

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18
Q

Any child with a history of hydrocephalus with shunt placement who presents with symptoms of increased ICP should be evaluated for assessment of ______________________________?

SG 20

SG 21

A

shunt malfunction

obstruction.

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19
Q

What are the signs of hydrocephalus

SG 5

A
  • The sunset sign
  • a bulging anterior fontanel
  • Widened suture lines
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20
Q

Postop care of the child with a VP shunt includes

A
  • regular assessment of head size and behavior
  • skin care and infection prevention at the surgical site,
  • parent education
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21
Q

the patient with meningitis usually has a high ____

A

white blood cell count

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22
Q

initial therapy of bacterial meningitis is:

A
  • isolation precautions
  • initiation of antimicrobial therapy
  • maintenance of hydration
  • maintenance of ventilation
  • reduction of increased ICP
  • management of systemic shock
  • control of seizures
  • control of temperature
  • treatment of complications
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23
Q

maintaining ____ is a prime concern for children with bacterial meningitis?

A

hydration

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24
Q

what are some quality patient outcomes for patients with bacterial meningitis?

A
  • early recognition of s/s of meningitis
  • antibiotics administered as soon as diagnosis is established
  • cerbral edema prevented
  • exposure prevented by early isolation
  • side effects managed
  • nuerologic sequelae prevented
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25
a ____ is a blood test used to detect a wide range of disorders including anemia, infection, and leukemia.
CBC - complete blood count
26
____ carry oxygen to the cells and reflect the health of the bone marrow
RBC
27
a decrease in RBC will present as:
weakness, fatigue, pallor
28
average RBC count is ___
4.5 to 5.5 million/mm3
29
____ reflects primarily the number of RBCs, but can also show the amount of ____ present in each cell.
hemoglobin, hemoglobin
30
Average hemoglobin values__
11.5 - 15.5 g/dl
31
______ is the percent volume of packed RBCs
hematacrit
32
average hematacrit values__
35-45%
33
__ is the index of production of mature RBCs by the bone marrow
reticulocyte count
34
average reticulocyte counts are__
0.5-1.5%
35
an increased amount of ____ is due to some stimulus to the bone marrow to up production
reticulocyte count
36
____ are on guard to fight infection
WBC
37
normal WBC count is__
4.5 to 13.5 x 10~3 cells/mm~3
38
what are the five major types of WBC
- basophils - eosinophils - lymphocytes - monocytes - neutrophils
39
___ are readily stainged with basic dyes, and release histamine, heparin, and serotonin
basophils
40
______ seen in allergies, asthman, eczema, and autoimmune diseases
eosinophils
41
______ can be type b and t. B become cells that produce antibodies. antibodies attach to a specific antigen making it easier to destroy. T attack antigens directly.
lymphocytes
42
______ are phagocytic, they are formed in the bone marrow, they change into macrophages and eat harmful bacteri, viruses, and fungi
monocytes
43
___they are produced in the bone marry and are also phagocytic
neutrophils
44
chronic anemia will manifest itself as__ SG 9
fatigue, decreased growth and pallor
45
one of the nurse's responsibilities, when anemia is suspected, is to _____ SG 9
- assess baseline energy functioning | - minimize demands
46
______ is the most prevalent and most preventable nutritional disorder in the US SG 9
iron deficiency anemia
47
the term infant will run out of iron stores at about ___ while a premature infant stores may last only _____
6 months | 2-3 months
48
an adequate dosage of iron turns the stools _____
tarry green or black color
49
What are signs and symptoms of Congenital Heart Disease?
- Congestive Heart Failure - Pallor or Cyanosis - Altered pulses - Murmur - Fatigue/irritability - Poor weight gain
50
Signs of Congestive heart failure
- Tachypnea - Tachycardia - Diaphoresis - Cardiomegaly - Hepatomegaly - Edema
51
____________ includes primarily anatomic abnormalities present at birth that result in abnormal cardiac function.
Congenital heart disease (CHD)
52
More frequently the diagnosis of Congenital Heart Disease will be made ___________ but can be seen _______ in severe cases
sometime after birth In Utero
53
It is important to remember that in infants and children, congestive heart failure is almost always a manifestation of ____________________
another underlying problem.
54
Primary congestive heart failure is ____________ in children.
very rare
55
______________ is an abnormal opening between the left and the right atria
Atrial Septal Defect
56
How does the blood flow in a child with an Atrial septal defect?
Blood flows from the left atrium through the defect into the lower pressure right atrium.
57
In patients with an Atrial Septal Defect blood flows from the left to the right atrium, causing an ___________flow of ___________ blood into the right side of the heart.
- increased | - oxygenated
58
Patients with an Atrial Septal Defect have an __________ ______________ Blood flow
Increased Pulmonary
59
Because of their compromised lung status, children with Increased Pulmonary Blood Flow are at increased risk of ________________ and also increased risk of _____________ and _________ Deficiencies
- Severe respiratory infection. - Poor growth - Nutritional deficiencies
60
Infants with Increased Pulmonary Blood Flow may due best with _________________ feedings?
Small frequent feedings
61
Many children with cardiac defects that similar to ASD will require diuretic therapy and medications such as ______________ and __________________ for the treatment of Congestive Heart Failure
- Lasix | - Digoxin
62
Which heart defect is often very well tolerated? | It can be a ___________ finding.
- Atrial Septal Defect | - Incidental
63
How is Atrial Septal Defect treated?
- Surgical Patch - blocks hole | - Repaired surgically
64
What defect is a failure of the Foramen Ovale to close?
Atrial Septal Defect
65
What is a Ventricular septal defect ?
an abnormal opening between the left and the right ventricle.
66
Why is a Ventricular Septal Defect hemodynamically more significant?
B/c there is greater difference in pressure between the right and the left ventricle thus larger amounts of blood may flow from the left ventricle to the right ventricle
67
Congestive Heart Failure is ________ is patients with Ventricular Septal Defect
Common
68
Like ASD Ventricular Septal Defect can be repaired _______ or _____________?
- surgically with sutures | - by placing a block
69
What are the Acyanotic Defects?
- Atrial Septal Defect - Ventricular Septal Defect - Patent Ductus Arteriosus
70
What causes the Ductus Arteriosus to close soon after birth ?
- Constricts in response to Oxygen and the loss of prostaglandins
71
Patent Ductus Arteriosus is extremely common in ______________ ?
premature infants
72
The Arteriosus can reopen in response to ?
Hypoxemia
73
What is the pathway of blood in a child with Patent Ductus Arteriosus?
blood is shunted from the aorta through the ductus into the pulmonary artery and back to the lungs leading to congestive heart failure
74
For many premies and some newborns a Patent Ductus Arteriosus defect can be successfully medically treated with a relatively high dose of ____________
indomethacin
75
Why can indomethacin be used to treat preemies and some newborns for Patent Ductus Arteriosus?
B/c it is an NSAID which are prostaglandin inhibitors
76
Treatment of a Patent Ductus Arteriosus
- Surgically | - Place a block in the Cath lab
77
Signs and symptoms of Defects Obstructing Blood Flow from the Ventricles
- Congestive Heart Failure | - Decreased systemic perfusion and perfusion
78
What should be done prior to performing a cardiac catheterization on a child? and Why?
- Assessment of the pedal pulse and capillary refill | - b/c the Femoral Vein and artery are almost always used during the procedure
79
In obstructive acyanotic defects blood is prevented from moving from the _______________ into the ___________ circulation
- Left ventricle | - Systemic
80
Children with Defects obstructing blood flow from the ventricles will frequently have
- decreased pulses - decreased urine output - poor gastrointestinal function - metabolic acidosis.
81
Nursing management for children with Defects obstructing blood flow from the ventricles
- close monitoring of urine output, | - assessment of acid base balance, and observation of level of consciousness.
82
Newborn infants with defects obstructing blood flow from the ventricles will often be placed on a _____________ infusion to maintain the ____________________ until reparative or palliative surgery can be performed
- prostaglandin e | - patency of the ductus arteriosus
83
In Sickle cell anemia the sickled ___________ form stiff rods in the RBC, preventing easy passage through the vessels, and they can cause blockage or SG 4
- hemoglobin | - vasoocclusion
84
_______ is called a "painful episode" that is characterized by ischemia causing mild to severe pain that may last from minutes to days longer in children with Sickle Cell anemia SG 4
vasoocclusive crisis
85
Nursing management for a child in sickle cell crisis SG 8
- rest - hydration/fluids - electrolyte replacement - analgesia - blood replacement - antibiotics to treat any existing infection
86
____ is a pooling of a large amount of blood usually in the spleen and infrequently the liver that causes a decreased blood volume and ultimately shock
sequestration crisis
87
if the mother and father are both carriers, what are the chances that their offspring will have sickle cell anemia? SG 1
1 in 4
88
Given that stroke can be a complication of SCA what is an intracranial doppler used for?
to monitor intracranial vascular flow and is performed yearly from 2-16.
89
treatments of SCA
blood transfusions hematopoietic stem cell transplant (HSCT)
90
_____________ offers a curative treatment for children with SCD
hematopoietic stem cell transplant (HSCT)
91
the defect in (thalassemia major) Cooley anemia lies in the deficiency to some degree in the ____. the hemoglobin is defective and the RBC's are weak, easily destroyed, leading to anemia.
beta chain
92
symptoms of thalassemia major are
- lacking the ability to produce normal, adult hemoglobin - chronic fatigue - failure to thrive
93
two major consequences of thalassemia are __ and ____, which leads to poor growth, impaired physical activity, facial and other bone deformities, fragile bones and enlargement of the liver and spleen.
- severe anemia | - expansion of the bone marrow in the bodies effort to produce more RBC
94
the only treatment to combat Cooley anemia is ____ and _____
- regular blood transfusions | - iron chelation therapy
95
Early signs of hemarthrosis (bleeding in the joints) are: SG 36
- feeling of stiffness, tingling, or achiness in the affected joint, followed by a decrease in joint movement - bleeding in the neck, mouth or thorax
96
treatment of hemophilia:
- DDVAP: helps release the manufactures of factor VIII (can be used as a preventative treatment prior to procedures, such as dentistry or sports). - clotting factors VIII or IX - recombinant clotting factors (bb) manufactured
97
General signs and symptoms of Defects Causing Decreased Pulmonary Blood Flow
hypoxemia cyanosis increased resp rate w/o resp distress poor growth clubbing polycythemia low PaO2 and O2 sat
98
What is polycythemia
increased production of RBC b/c the body wants more O2. Causes viscous blood, can lead to ischemia, stroke
99
Main Defect Causing Decreased Pulmonary Blood Flow that we studied
Tetralogy of Fallot
100
Tetralogy of Fallot SS
``` blue no CHF - b/c blood moves to body ok normal pulse organ hypoxemia tec spells ```
101
Tec Spell (hypercyanotic spell) SG 37
Severe, sudden anoxia Workload on the heart is too high so the heart beats harder and harder. Because of this, the musculature around the pulmonary valve can't relax, and the RV to pulmonary artery passage becomes obstructed by this tension. Patient gets super cyanotic and passes out
102
Signs of a tec spell in children SG 37
Crouching- they can feel the tec spell and crouching causes abdominal pressure, pushing the blood into the right ventricle. This temporarily fixes it.
103
Nursing intervention for tec spell SG 37
- Bend legs to belly if not already there | - Morphine. O2 won't do much but we often still give to these kids
104
Nursing Management for Tetralogy of Fallot
O2 not really useful so don't give much. Reduce cardiac demands. Supportive care until surgery (will have in first year of life to correct the defects)
105
S&S of Defects causing Mixed Blood Flow
cyanosis L&R heart failure low PaO2 VERY sick
106
Nursing Care of patient with Defect causing Mixed Blood Flow
- Reduce cardiac demand - Give prostaglandins til surgery Supportive
107
General pathology of Defects causing Mixed Blood Flow
Blood comes from both sides of heart and mixes therefore low PaO2 b/c of the mixing
108
Transposition of Great Vessels pathology
Aorta rises off RV and pulmonary artery off LV. 2 Completely separate circulations! 2 Closed systems: -One that is highly oxygenated and keeps going to lungs -Second is low O2 and keeps going to body To prevent baby from dying, body has open ductus arteriosus and a VSD to allow some mixing.
109
Temporary Treatment for Transposition of Great Vessels until they get major surgery to correct defects
Prostoglandins!!! Then, in cath lab they pass a balloon thru the forament ovale, blow it thru the LA and yank it back thru the atrial septum to make an ASD and allow more mixing
110
3 Acquired Cardiac Disorders we discussed
Bacterial Endocarditis Rheumatic Fever Kawasaki Disease
111
Rheumatic Fever pathology
untreated Strep throat causes this multisystem disease
112
S&S of Rheumatic Fever
Eye inflammation | Heart, brain, cardiac damage
113
Treatment of Rheumatic fever
antibiotics | long term aspirin?? verify this
114
Nursing Care for Rheumatic fever
- strep care - prevent recurring infxns - prevent longterm heart damage (every recurrence of this disease is worse)
115
Pathology of Kawasaki Disease
Acute vasculitis everywhere in body leading to heart damage and coronary aneurysm Self limiting No known cause!
116
S&S of Kawasaki
``` High fever unresponsive to antipyretics irritability errythema peeling of skin edema red eyes strawberry tongue ```
117
Treatment of Kawasaki
IV gamma globulin and aspirin (don't care about Rye risk b/c benefit outweighs)
118
an abnormal, often cancerous, growth of tissue
neoplasms
119
in people with leukemia, the _________ produces abnormal white blood cells, which don't function properly
bone marrow
120
Definitive diagnosis of leukemia is based on
bone marrow aspiration and/or biopsy
121
Symptoms of leukemia are: SG 2
-infection -fever -enlarged spleen -lymph nodes and liver enlargement -persistent fatigue -weakness -easy bleeding or bruising -bone pain or tenderness -weight loss -
122
pre-chemo: | CHEMO
``` C- consent procedures H- health assessment E- evaluation of parents understanding M- securing presence of child's mother or father O- overview of treatment ```
123
intra-chemo: | SAFE
S- safe administration A- assessments of intravenous central line site F- provision of IV fluids E- assessment of electrolytes
124
post-chemo: | SOUND
S- symptoms needing attention O- observation for adverse effects of chemo U- adequacy of urine output N- need for nursing care/ further education D- drugs needed for symptom management such as nausea or mouth care
125
What defect is caused by narrowing of the aortic arch
Coarctation of the aorta
126
Coarctation of the aorta is characterized by localized narrowing near the insertion of the ductus arteriosus, which results in _____________ in the head and upper extremities and ___________ in the body and lower extremities.
increased pressure decreased pressure
127
How is HIV transmitted in children most commonly?
During childbirth or breastfeeding for young children; risky behaviors for 13-24 yr olds
128
What do children with Coarctation of the Aorta present with?
- Signs of congestive heart failure - elevated pulses and blood pressure above the level of the defect - Decreased pulses below the defect
129
What changes would you see in the urinary system, blood gas and GI system be affected in a patient with a Coarctation of the Aorta who has a severe stricture?
- Decreased urine output - Metabolic Acidosis - Decreased gastrointestinal function
130
What do children with Coarctation of the Aorta present with?
- Signs of congestive heart failure - elevated pulses and blood pressure above the level of the defect - Decreased pulses below the defect
131
How will the urinary system, blood gas and GI system be affected in a patient with a Coarctation of the Aorta who has a severe stricture?
- Decreased urine output - Metabolic Acidosis - Decreased gastrointestinal function
132
What is Polycythemia
an increased number of red blood cells, increases the oxygen-carrying capacity of the blood.
133
Neonates with a Coarctation of the Aorta will be treated with a _________________ infusion.
Prostaglandin E infusion
134
Preoperative care of the child with coarctation of the aorta focuses on _____________ and ________________________________ that may develop due to poor organ perfusion.
- Stabilization | - Correcting metabolic abnormalities
135
The cardinal sign of Coarctation of the aorta is?
Marked gradient between pulses and blood pressure in the upper and lower extremities
136
Acyanotic Defects that increase pulmonary blood flow include
- Ventricular Septal Defect - Atrial Septal Defect - Patent Ductus Arteriosus
137
Acyanotic Defects that obstruct blood from ventricles into the body include?
- Coarctation of Aorta - Aortic Stenosis - Pulmonic Stenosis
138
Cyanotic defects that decrease pulmonary blood flow include?
- Tetralogy of Fallot | - Tricuspid atresia
139
Cyanotic defects that mix blood flow include?
- Transposition of the Great Vessels - Total anomalous pulmonary venous return - Truncus arteriosus - Hypoplastic left heart syndrom
140
polycythemia
Elevated Red Blood Cells
141
Hypercyanotic spells, also referred to as blue spells or tet spells because they are often seen in infants with ____________ may occur in any child whose heart defect includes obstruction to pulmonary blood flow and communication between the ventricles.
tetralogy of Fallot,
142
what are some nursing interventions that can be done for a child in VOC (vasoocclusion crisis): SG 8
- pharmacologic treatments (start with NSAIDS then progress to opioids) - hydration - physical therapy - non-pharmacologic and complementary treatment
143
Family education for child with sickle cell SG 8
(1) seek early intervention for problems, such as fever of 38.5 ° C (101.3 ° F) or greater; (2) give penicillin as ordered; (3) recognize signs and symptoms of stroke, splenic sequestration, as well as respiratory problems that can lead to hypoxia (4) treat the child normally.
144
If a febrile seizure lasts more than ___ minutes, parents should seek medical attention right away. Parents should call for emergency assistance (911) and not place the child who is actively having a seizure in the car. SG 16
5
145
An infant with suspected or confirmed hydrocephalus is observed carefully for signs of increasing ventricular size and increasing ICP. In infants, the head is measured ______at the point of __________ measurement, the frontooccipital circumference SG 13 SG 20 SG 21
- daily | - largest
146
Nursing interventions for a child with a new ventriculoperitoneal shunt? SG 20 SG 21
- Accurate and frequent documentation of the incision site; - amount, color, and consistency of drainage into the device - the child's vital and neurologic signs are an important part of the nursing care.
147
Because infection is the greatest hazard of the postoperative period of a VP shunt placement, nurses are continually on the alert for the usual manifestations of CSF infection, including SG 20 SG 21 SG 31
- elevated temperature - poor feeding - vomiting - decreased responsiveness, and seizure activity.
148
nursing interventions for hemophilia SG 36
- prevent bleeding - recognize and control bleeding - prevent crippling effects of bleeding - support the family and prepare for home care
149
The objectives of nursing care for a patient with thalassemia are to SG 27
(1) promote compliance with transfusion and chelation therapy, (2) assist the child in coping with the anxiety-provoking treatments and the effects of the illness (3) foster the child's and family's adjustment to a chronic illness 4) observe for complications of multiple blood transfusions.
150
Expected lab values for a child with leukemia | SG 22
- low WBC (leukocyte) count less than 50,000 - low blood counts - Elevated immature cells or blasts.
151
A PaO2 of 100 mm Hg or higher suggests ______ disease, and a PaO2 lower than 100 mm Hg suggests ________ disease SG 44
- lung | - cardiac
159
Side effects of a child on prednisone? SG 12
- growth suppression (adrenal suppression) - weight gain - decreased bone density. - immunosuppressed
185
What is the inheritance pattern of Sickle Cell Disorder? SG 1.
essentially that of an autosomal recessive disorder.
186
The Administration of what three vaccines are recommended for children with Sickle Cell Anemia due to their susceptibility to infection? SG 29
1. pneumococcal 2. H. influenzae 3. meningococcal
187
In addition to routine immunizations, children with SCD should receive a yearly ___________ vaccination SG 29
influenza
188
In Children with Sickle Cell Anemia, oral ____________ prophylaxis is recommended by 2 months old to reduce the chance of pneumococcal sepsis. SG 29
penicillin
189
Teaching priorities for a child with sickle cell disorder SG 15
- Explain signs of developing complications - Reinforce basic info about inheritance - Offer genetic counseling if appropriate - Stress importance of adequate nutrition - Stress infection prevention/ - Encourage frequent health evaluations
190
Nurse prioritizes nursing management of child with HIV SG 3
- Education concerning transmission - Control of infectious diseases - appropriate storage of special medications and equipment (e.g., needles and syringes), are emphasized.
191
Discharge teaching for a child with a VP shunt SG - 31
- Keep child flat in supine position - Child will require life long treatment - Child will require more than 1 shunt in their life time - Head circumference should gradually decrease
193
Parent teaching for a child with a febrile seizure SG 16
- Children with a family history of febrile seizures are at increased risk for both a single & recurrent febrile seizure - If a febrile seizure lasts more than 5 minutes, parents should seek medical attention right away. - reassurance that children who have had febrile seizures but do not have underlying developmental problems will perform as well as other children academically and behaviorally
194
Parent teaching for a child with a febrile seizure SG 17
- Note any changes in behaviors observed before or after the seizure - Not activities during the seizure
195
Care of the child with meningitis focuses on SG 33
- systemic care of the child - identification and treatment of the causative organism - preventing brain injury caused by increased intercranial pressure.
196
Because bacterial meningitis can be contagious _______ & _______ may be necessary. SG 33
- isolation precautions | - contact tracking
197
Nursing assessment for a child on prostaglandin-e SG 30
- monitor pulmonary artery and descending aorta pressures - Palpate femoral pulse frequently to assess - monitor urinary output. circulation to lower extremities. -BP may be monitored in a lower and an upper extremity simultaneously.
198
Clinical manifestations of congestive heart failure include SG 38
- irritability - tachypnea - poor feeding - pallor.
199
Normal Pa02 SG 45 SG 46
80 -100mmHg
200
Normal range for PaC02 SG 45 SG 46
35 - 45
201
Normal range for HC03 SG 45 SG 46
22 - 26
202
Sa02 SG 45 SG 46
93 - 100
203
Nursing Interventions for Respiratory Alkalosis SG 45 SG 46
- Prevent patient from hyperventilating/ slow breathing | - Breath into a paper bag
204
Nursing Interventions for Respiratory Acidosis SG 45 SG 46
- Administer oxygen | - encourage deep breathing
205
The current treatment of children with Kawasaki disease includes __________ along with _________ SG 48
- high-dose intravenous immunoglobulin (IVIG) (gamma globulin) - aspirin therapy.
206
Rheumatic fever is a multisystem disease that involves joints, skin, brain, mucus membranes and the heart. ___________ damage is the most severe complication. SG 44
- Cardiac valvular
207
What valve is most frequently affected in a patient with Rheumatic Fever? SG 44
- mitral valve
208
A synthetic form of vasopressin, also known as ________, increases plasma factor VIII activity and is the treatment of choice in mild __________
DDAVP hemophilia